DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hrb27C and Rbm24

DIOPT Version :9

Sequence 1:	NP_001162897.1	Gene:	Hrb27C / 33968	FlyBaseID:	FBgn0004838	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	NP_001074894.1	Gene:	Rbm24 / 666794	MGIID:	3610364	Length:	236	Species:	Mus musculus

Alignment Length:	256	Identity:	56/256 - (21%)
Similarity:	101/256 - (39%)	Gaps:	53/256 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 KVFLGGLPSNVTETDLRTFFNRYGKVTEVVIMYDQEKKKSRGFGFLSFEEESSVEHVTNERYINL 161
            |:|:||||.:.|:..||.:|..:|.:.|.|::.|::..||||:||::..:.::.|....:....:
Mouse    12 KIFVGGLPYHTTDASLRKYFEVFGDIEEAVVITDRQTGKSRGYGFVTMADRAAAERACKDPNPII 76

  Fly   162 NGKQVEIKKA---------EPRDGSGGQNSNNSTVGGAYGKLGNECSHWGPHHAPINMMQGQNGQ 217
            :|::..:..|         :|....|.|..:.:.:...:|             .|.:.:..|...
Mouse    77 DGRKANVNLAYLGAKPRIMQPGFAFGVQQLHPALIQRPFG-------------IPAHYVYPQAFV 128

  Fly   218 MGGPPLNMPIGAPNMMPGYQGWGTSPQQQQYGYGNSGPGSYQGWGAPPGPQGPPPQWSNYAGPQQ 282
            ..|      :..|::.|......|:|.....|      .:|             .|:|  |....
Mouse   129 QPG------VVIPHVQPTAAAASTTPYIDYTG------AAY-------------AQYS--AAAAA 166

  Fly   283 TQGYGGYDMYNSTSTGAPSG--PSGGGSWNSWNMPPNSAGP-TGAPGAGAGTATDMYSRAQ 340
            ......||.|...::.|.:|  .:||.|: :...|..:|.| |.|..|.|..|...:.:.|
Mouse   167 AAAAAAYDQYPYAASPAAAGYVTTGGYSY-AVQQPITAAAPGTAAAAAAAAAAAAAFGQYQ 226

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hrb27C	NP_001162897.1	RRM1_DAZAP1	8..89	CDD:241018
Hrb27C	NP_001162897.1	RRM2_DAZAP1	94..173	CDD:240773	23/84 (27%)
Rbm24	NP_001074894.1	RRM_RBM24_RBM38_like	11..86	CDD:409818	22/73 (30%)
Rbm24	NP_001074894.1	Necessary for interaction with EIF4E. /evidence=ECO:0000250\|UniProtKB:Q9BX46	175..199		6/24 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4205
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810