DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hrb27C and dazap1

DIOPT Version :9

Sequence 1:	NP_001162897.1	Gene:	Hrb27C / 33968	FlyBaseID:	FBgn0004838	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	XP_021335308.1	Gene:	dazap1 / 561459	ZFINID:	ZDB-GENE-070212-1	Length:	469	Species:	Danio rerio

Alignment Length:	465	Identity:	174/465 - (37%)
Similarity:	213/465 - (45%)	Gaps:	128/465 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DERGKLFVGGLSWETTQENLSRYFCRFGDIIDCVVMKNNESGRSRGFGFVTFADPTNVNHVLQNG 68
            ||.||||||||.|.||||.|..||.::|:::|||:||:..:.:|||||||.|.||..|..||...
Zfish    20 DEIGKLFVGGLDWSTTQETLRNYFSQYGEVVDCVIMKDKSTNQSRGFGFVKFKDPNCVRTVLDTK 84

  Fly    69 PHTLDGRTIDPKPCNPRTLQKPK-------KGG------GYKVFLGGLPSNVTETDLRTFFNRYG 120
            ||.||||.||||||.||.:|..|       ||.      ..|:|:||:|.|..|.:||.:|||:|
Zfish    85 PHNLDGRNIDPKPCTPRGMQPEKTRTKDGWKGSKSDSNKSKKIFVGGIPHNCGEAELRDYFNRFG 149

  Fly   121 KVTEVVIMYDQEKKKSRGFGFLSFEEESSVEHVTNERYINLNGKQVEIKKAEPRDGSGGQNSNNS 185
            .|||||::||.||::.|||||::||.|.||:...|..:.::.||:||:|||||||..
Zfish   150 VVTEVVMIYDAEKQRPRGFGFITFEAEQSVDQAVNMHFHDIMGKKVEVKKAEPRDSK-------- 206

  Fly   186 TVGGAYGKLGNECSHWGPHHAPINMMQGQNGQMGGPPLNMPIGAPNMMPGY--QGWGTSPQQQQY 248
              ..|.|:||  .:.|||.    .::...||....|       ||.....|  ||...|..|...
Zfish   207 --APAPGQLG--ANQWGPR----AIISAANGWAAQP-------APTWQQSYGPQGVWVSTGQPLA 256

  Fly   249 GYGNSGPGSYQGWGAP---PGP------QGPP------PQWSNYAGPQQ---TQGYGGYDMYNST 295
            |||...|.   |.|||   |.|      ..||      ||  .|  |||   ||...||
Zfish   257 GYGPPLPA---GRGAPAQAPSPFNAFLVAAPPTGGFGAPQ--GY--PQQGFSTQPQFGY------ 308

  Fly   296 STGAPSGPSGGGSWNSWNMPPNSAGPTGAPGAGAGTATDMYSRAQAWATGGPSTTGPVGGMPRTG 360
            |.|.|.    |..:.:..|||    |...|||                       ||:|..|.|.
Zfish   309 SFGTPQ----GDQFVAQGMPP----PPATPGA-----------------------GPLGFAPATT 342

  Fly   361 PGNSASKSGSEYDYGGYGSGYDYDYSNY----------------VKQEGASNYGAGPRSAYGNDS 409
            |....||:.....        |:.||.|                ..|||..||...| ||||
Zfish   343 PSQDLSKAAPAQP--------DFSYSQYEYLLRCSTEEGKPFMVELQEGLGNYPQDP-SAYG--- 395

  Fly   410 STQPPYATSQ 419
            .|:|.:...|
Zfish   396 PTRPSHTYVQ 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hrb27C	NP_001162897.1	RRM1_DAZAP1	8..89	CDD:241018	48/80 (60%)
Hrb27C	NP_001162897.1	RRM2_DAZAP1	94..173	CDD:240773	40/84 (48%)
dazap1	XP_021335308.1	RRM1_DAZAP1	24..105	CDD:241018	48/80 (60%)
		RRM2_DAZAP1	127..202	CDD:240773	39/74 (53%)
		FtsK	<220..>430	CDD:332908	69/253 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589922
Domainoid	1	1.000	76	1.000	Domainoid score	I8946
eggNOG	1	0.900	-	-		E1_KOG4205
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	237	1.000	Inparanoid score	I3351
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1565323at2759
OrthoFinder	1	1.000	-	-		FOG0000417
OrthoInspector	1	1.000	-	-		oto39043
orthoMCL	1	0.900	-	-		OOG6_106744
Panther	1	1.100	-	-	LDO	PTHR48027
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1869
SonicParanoid	1	1.000	-	-		X310
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.830