DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hrb27C and Dazap1

DIOPT Version :9

Sequence 1:	NP_001162897.1	Gene:	Hrb27C / 33968	FlyBaseID:	FBgn0004838	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	XP_006241030.1	Gene:	Dazap1 / 362836	RGDID:	1305280	Length:	406	Species:	Rattus norvegicus

Alignment Length:	439	Identity:	167/439 - (38%)
Similarity:	211/439 - (48%)	Gaps:	103/439 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DERGKLFVGGLSWETTQENLSRYFCRFGDIIDCVVMKNNESGRSRGFGFVTFADPTNVNHVLQNG 68
            ||.||||||||.|.||||.|..||.::|:::|||:||:..:.:|||||||.|.||..|..||.:.
  Rat     7 DEIGKLFVGGLDWSTTQETLRSYFSQYGEVVDCVIMKDKTTNQSRGFGFVKFKDPNCVGTVLASR 71

  Fly    69 PHTLDGRTIDPKPCNPRTLQ----KPKKG----------GGYKVFLGGLPSNVTETDLRTFFNRY 119
            |||||||.||||||.||.:|    :||:|          ...|:|:||:|.|..||:||.:|.::
  Rat    72 PHTLDGRNIDPKPCTPRGMQPERTRPKEGWQKGPRSDSSKSNKIFVGGIPHNCGETELREYFKKF 136

  Fly   120 GKVTEVVIMYDQEKKKSRGFGFLSFEEESSVEHVTNERYINLNGKQVEIKKAEPRDGSGGQNSNN 184
            |.|||||::||.||::.|||||::||:|.||:...|..:.::.||:||:|:|||||      |.|
  Rat   137 GVVTEVVMIYDAEKQRPRGFGFITFEDEQSVDQAVNMHFHDIMGKKVEVKRAEPRD------SKN 195

  Fly   185 STVG--GAYGKLGNECSHWGPHHAPINMMQGQNGQMGGPPLNMPIGAPNMMPGY--QGWGTSPQQ 245
            ...|  ||        |.||...||    ...||..|.||       |....||  ||......|
  Rat   196 QAPGQPGA--------SQWGSRVAP----SAANGWAGQPP-------PTWQQGYGPQGMWVPAGQ 241

  Fly   246 QQYGYGNSGPGSYQGWGAPPGPQGPPPQWSNYA--------GPQQ--TQGYGGYDMYNSTSTGAP 300
            ...|||....|.    ||||    |||.:::|.        .|.|  .||||....: |...|.|
  Rat   242 AIGGYGPPPAGR----GAPP----PPPPFTSYIVSTPPGGFPPPQGFPQGYGAPPQF-SFGYGPP 297

  Fly   301 SGPSGGGSWNSWNMPPNSAGPTGAPGAGAGTATDMYSRAQAWATGGPSTTGPVGGMPRTGPGNSA 365
            ..|....:      ||....|...|||           |.......||...|....|.|
  Rat   298 PPPPDQFA------PPGVPPPPATPGA-----------APLAFPPPPSQAAPDMSKPPT------ 339

  Fly   366 SKSGSEYDYGGYGSGYDYDYSNYVKQEGASNYGAGPRSAYGNDSSTQPP 414
              :..::.||.||.|.|           .|.:|.|     .:|.|.|||
  Rat   340 --AQPDFPYGQYGYGQD-----------LSGFGQG-----FSDPSQQPP 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hrb27C	NP_001162897.1	RRM1_DAZAP1	8..89	CDD:241018	50/84 (60%)
Hrb27C	NP_001162897.1	RRM2_DAZAP1	94..173	CDD:240773	38/78 (49%)
Dazap1	XP_006241030.1	RRM1_DAZAP1	11..92	CDD:409988	49/80 (61%)
Dazap1	XP_006241030.1	RRM2_DAZAP1	111..190	CDD:409765	38/78 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348780
Domainoid	1	1.000	76	1.000	Domainoid score	I8787
eggNOG	1	0.900	-	-		E1_KOG4205
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	237	1.000	Inparanoid score	I3304
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1565323at2759
OrthoFinder	1	1.000	-	-		FOG0000417
OrthoInspector	1	1.000	-	-		oto95567
orthoMCL	1	0.900	-	-		OOG6_106744
Panther	1	1.100	-	-	LDO	PTHR48027
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X310
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760