DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hrb27C and HNRNPA2B1

DIOPT Version :9

Sequence 1:	NP_001162897.1	Gene:	Hrb27C / 33968	FlyBaseID:	FBgn0004838	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	NP_112533.1	Gene:	HNRNPA2B1 / 3181	HGNCID:	5033	Length:	353	Species:	Homo sapiens

Alignment Length:	394	Identity:	128/394 - (32%)
Similarity:	188/394 - (47%)	Gaps:	79/394 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EEDERGKLFVGGLSWETTQENLSRYFCRFGDIIDCVVMKNNESGRSRGFGFVTFADPTNVNHVLQ 66
            |:::..|||:||||:|||:|:|..|:.::|.:.|||||::..|.||||||||||:....|:..:.
Human    16 EKEQFRKLFIGGLSFETTEESLRNYYEQWGKLTDCVVMRDPASKRSRGFGFVTFSSMAEVDAAMA 80

  Fly    67 NGPHTLDGRTIDPKPCNPRTLQKPKKGGGY----KVFLGGLPSNVTETDLRTFFNRYGKVTEVVI 127
            ..||::|||.::||....|  ::..|.|.:    |:|:||:..:..|..||.:|..|||:..:.|
Human    81 ARPHSIDGRVVEPKRAVAR--EESGKPGAHVTVKKLFVGGIKEDTEEHHLRDYFEEYGKIDTIEI 143

  Fly   128 MYDQEKKKSRGFGFLSFEEESSVEHVTNERYINLNGKQVEIKKAEPRDGSGGQNSNNSTVGGAYG 192
            :.|::..|.|||||::|::...|:.:..::|..:||...|::||..|.......|:.|..||.:|
Human   144 ITDRQSGKKRGFGFVTFDDHDPVDKIVLQKYHTINGHNAEVRKALSRQEMQEVQSSRSGRGGNFG 208

  Fly   193 KLGNECSHWGPHHAPINMMQGQNGQMG-GPPLNMPIGAP------NMMPGYQGWGTSPQQQQY-- 248
             .|:.              :|..|..| ||..|...|:.      ....||.|:|..|....:
Human   209 -FGDS--------------RGGGGNFGPGPGSNFRGGSDGYGSGRGFGDGYNGYGGGPGGGNFGG 258

  Fly   249 --GYGNSGPGSYQGWGAPPGPQGPPPQWSNYAGPQQTQGY-GGYDMYNSTSTGAPSGPSGGGSWN 310
              ||| .|.|.|.|.|         |.:.|..|     || ||||.|.       .|..|.|::|
Human   259 SPGYG-GGRGGYGGGG---------PGYGNQGG-----GYGGGYDNYG-------GGNYGSGNYN 301

  Fly   311 ---SWNMPPNSAGPTGAPGAGAGTATDMYSRAQAWATGGPSTTGPVGGMPRTGPGNSASKSGSEY 372
               ::|..|::.||..:...|                |..:..||.|| ...|||.|....|
Human   302 DFGNYNQQPSNYGPMKSGNFG----------------GSRNMGGPYGG-GNYGPGGSGGSGG--- 346

  Fly   373 DYGG 376
             |||
Human   347 -YGG 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hrb27C	NP_001162897.1	RRM1_DAZAP1	8..89	CDD:241018	39/80 (49%)
Hrb27C	NP_001162897.1	RRM2_DAZAP1	94..173	CDD:240773	28/82 (34%)
HNRNPA2B1	NP_112533.1	Nuclear localization signal. /evidence=ECO:0000255	9..15
		RRM1_hnRNPA2B1	19..99	CDD:410155	38/79 (48%)
		RRM2_hnRNPA2B1	112..191	CDD:409995	27/78 (35%)
		Disordered. /evidence=ECO:0000269\|PubMed:26544936	193..353		58/215 (27%)
		HnRNPA1	302..326	CDD:402981	6/39 (15%)
		Nuclear targeting sequence. /evidence=ECO:0000250	308..347		14/59 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910