DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hrb27C and Hnrnpa3

DIOPT Version :9

Sequence 1:	NP_001162897.1	Gene:	Hrb27C / 33968	FlyBaseID:	FBgn0004838	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	NP_666242.2	Gene:	Hnrnpa3 / 229279	MGIID:	1917171	Length:	379	Species:	Mus musculus

Alignment Length:	425	Identity:	131/425 - (30%)
Similarity:	190/425 - (44%)	Gaps:	105/425 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EEDERGKLFVGGLSWETTQENLSRYFCRFGDIIDCVVMKNNESGRSRGFGFVTFADPTNVNHVLQ 66
            |.::..|||:||||:|||.::|..:|.::|.:.|||||::.::.|||||||||::....|:..:.
Mouse    30 EPEQLRKLFIGGLSFETTDDSLREHFEKWGTLTDCVVMRDPQTKRSRGFGFVTYSCVEEVDAAMC 94

  Fly    67 NGPHTLDGRTIDPKPCNPRTLQKPKKGGGY----KVFLGGLPSNVTETDLRTFFNRYGKVTEVVI 127
            ..||.:|||.::||....|  :...|.|.:    |:|:||:..:..|.:||.:|.:|||:..:.:
Mouse    95 ARPHKVDGRVVEPKRAVSR--EDSVKPGAHLTVKKIFVGGIKEDTEEYNLRDYFEKYGKIETIEV 157

  Fly   128 MYDQEKKKSRGFGFLSFEEESSVEHVTNERYINLNGKQVEIKKAEPRD---------GSGGQNSN 183
            |.|::..|.|||.|::|::..:|:.:..::|..:||...|:|||..:.         |.||.:.|
Mouse   158 MEDRQSGKKRGFAFVTFDDHDTVDKIVVQKYHTINGHNCEVKKALSKQEMQSAGSQRGRGGGSGN 222

  Fly   184 NSTVGGAYGKLGNECSHWGPHHAPINMMQGQNGQMGGPPLNMPIGAPNMMPGYQGWGTSPQQQQY 248
            ....||.:|..|...              |:.|..||            ..|| |.|....:..|
Mouse   223 FMGRGGNFGGGGGNF--------------GRGGNFGG------------RGGY-GGGGGGSRGSY 260

  Fly   249 GYGNSGPGSYQGWGAPPGPQGPPPQWSNYAG--------PQQTQGY----GGYDMYNSTSTGAPS 301
            |   .|.|.|.|:|...|..|..|.:|:..|        ..|..||    ||||.||.      .
Mouse   261 G---GGDGGYNGFGGDGGNYGGGPGYSSRGGYGGGGPGYGNQGGGYGGGGGGYDGYNE------G 316

  Fly   302 GPSGGGSWNSWNMPPNSAGPTGAPGAGAGTATDM--YSRAQAWATGGPSTTGPVGGMPRTGPGNS 364
            |..|||::                 .|.|...|.  || .|..:..||...|..||
Mouse   317 GNFGGGNY-----------------GGGGNYNDFGNYS-GQQQSNYGPMKGGSFGG--------- 354

  Fly   365 ASKSGSEYDYGGYGSGYDYDYSNYVKQEGASNYGA 399
             ..|||.|. ||||||           .|:..||:
Mouse   355 -RSSGSPYG-GGYGSG-----------GGSGGYGS 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hrb27C	NP_001162897.1	RRM1_DAZAP1	8..89	CDD:241018	36/80 (45%)
Hrb27C	NP_001162897.1	RRM2_DAZAP1	94..173	CDD:240773	28/82 (34%)
Hnrnpa3	NP_666242.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35		1/4 (25%)
		RRM1_hnRNPA_like	36..113	CDD:409992	35/76 (46%)
		RRM2_hnRNPA3	126..205	CDD:409996	27/78 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	204..225		4/20 (20%)
		HnRNPA1	332..>348	CDD:402981	6/16 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	335..379		21/65 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1869
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940