DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hrb27C and HNRNPA3

DIOPT Version :9

Sequence 1:	NP_001162897.1	Gene:	Hrb27C / 33968	FlyBaseID:	FBgn0004838	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	NP_001317178.1	Gene:	HNRNPA3 / 220988	HGNCID:	24941	Length:	378	Species:	Homo sapiens

Alignment Length:	419	Identity:	132/419 - (31%)
Similarity:	192/419 - (45%)	Gaps:	94/419 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EEDERGKLFVGGLSWETTQENLSRYFCRFGDIIDCVVMKNNESGRSRGFGFVTFADPTNVNHVLQ 66
            |.::..|||:||||:|||.::|..:|.::|.:.|||||::.::.|||||||||::....|:..:.
Human    30 EPEQLRKLFIGGLSFETTDDSLREHFEKWGTLTDCVVMRDPQTKRSRGFGFVTYSCVEEVDAAMC 94

  Fly    67 NGPHTLDGRTIDPKPCNPRTLQKPKKGGGY----KVFLGGLPSNVTETDLRTFFNRYGKVTEVVI 127
            ..||.:|||.::||....|  :...|.|.:    |:|:||:..:..|.:||.:|.:|||:..:.:
Human    95 ARPHKVDGRVVEPKRAVSR--EDSVKPGAHLTVKKIFVGGIKEDTEEYNLRDYFEKYGKIETIEV 157

  Fly   128 MYDQEKKKSRGFGFLSFEEESSVEHVTNERYINLNGKQVEIKKAEPRD---------GSGGQNSN 183
            |.|::..|.|||.|::|::..:|:.:..::|..:||...|:|||..:.         |.||.:.|
Human   158 MEDRQSGKKRGFAFVTFDDHDTVDKIVVQKYHTINGHNCEVKKALSKQEMQSAGSQRGRGGGSGN 222

  Fly   184 NSTVGGAYGKLGNECSHWGPHHAPINMMQGQNGQMGGPPLNMPIGAPNMMPGYQGWGTSPQQQQY 248
            ....||.:|..|...              |:.|..||            ..|| |.|....:..|
Human   223 FMGRGGNFGGGGGNF--------------GRGGNFGG------------RGGY-GGGGGGSRGSY 260

  Fly   249 GYGNSGPGSYQGWGAPPGPQGPPPQWSNYAGPQQTQGYGGYDMYNSTSTGAP------SGPSGGG 307
            |   .|.|.|.|:|...|..|..|.:|:..      ||||         |.|      .|..|||
Human   261 G---GGDGGYNGFGGDGGNYGGGPGYSSRG------GYGG---------GGPGYGNQGGGYGGGG 307

  Fly   308 SWNSWNMPPNSAGPTGAPGAGAGTATDM--YSRAQAWATGGPSTTGPVGGMPRTGPGNSASKSGS 370
            .::.:|...|..|  |..| |.|...|.  || .|..:..||...|..||          ..|||
Human   308 GYDGYNEGGNFGG--GNYG-GGGNYNDFGNYS-GQQQSNYGPMKGGSFGG----------RSSGS 358

  Fly   371 EYDYGGYGSGYDYDYSNYVKQEGASNYGA 399
            .|. ||||||           .|:..||:
Human   359 PYG-GGYGSG-----------GGSGGYGS 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hrb27C	NP_001162897.1	RRM1_DAZAP1	8..89	CDD:241018	36/80 (45%)
Hrb27C	NP_001162897.1	RRM2_DAZAP1	94..173	CDD:240773	28/82 (34%)
HNRNPA3	NP_001317178.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35		1/4 (25%)
		RRM1_hnRNPA_like	36..113	CDD:409992	35/76 (46%)
		RRM2_hnRNPA3	126..205	CDD:409996	27/78 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	204..225		4/20 (20%)
		HnRNPA1	331..>347	CDD:402981	6/16 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	336..378		20/63 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1869
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940