Protein Alignment Hrb27C and HNRNPA3

DIOPT Version :10

• Sequence 1: NP_476869.1
• Gene: Hrb27C / 33968
• FlyBaseID: FBgn0004838
• Length: 421
• Species: Drosophila melanogaster
• Sequence 2: NP_919223.1
• Gene: HNRNPA3 / 220988
• HGNCID: 24941
• Length: 378
• Species: Homo sapiens
• Alignment Length: 419
• Identity: 132/419 - (31%)
• Similarity: 192/419 - (45%)
• Gaps: 94/419 - (22%)

  Fly     2 EEDERGKLFVGGLSWETTQENLSRYFCRFGDIIDCVVMKNNESGRSRGFGFVTFADPTNVNHVLQ 66
            |.::..|||:||||:|||.::|..:|.::|.:.|||||::.::.|||||||||::....|:..:.
Human    30 EPEQLRKLFIGGLSFETTDDSLREHFEKWGTLTDCVVMRDPQTKRSRGFGFVTYSCVEEVDAAMC 94

  Fly    67 NGPHTLDGRTIDPKPCNPRTLQKPKKGGGY----KVFLGGLPSNVTETDLRTFFNRYGKVTEVVI 127
            ..||.:|||.::||....|  :...|.|.:    |:|:||:..:..|.:||.:|.:|||:..:.:
Human    95 ARPHKVDGRVVEPKRAVSR--EDSVKPGAHLTVKKIFVGGIKEDTEEYNLRDYFEKYGKIETIEV 157

  Fly   128 MYDQEKKKSRGFGFLSFEEESSVEHVTNERYINLNGKQVEIKKAEPRD---------GSGGQNSN 183
            |.|::..|.|||.|::|::..:|:.:..::|..:||...|:|||..:.         |.||.:.|
Human   158 MEDRQSGKKRGFAFVTFDDHDTVDKIVVQKYHTINGHNCEVKKALSKQEMQSAGSQRGRGGGSGN 222

  Fly   184 NSTVGGAYGKLGNECSHWGPHHAPINMMQGQNGQMGGPPLNMPIGAPNMMPGYQGWGTSPQQQQY 248
            ....||.:|..|...              |:.|..||            ..|| |.|....:..|
Human   223 FMGRGGNFGGGGGNF--------------GRGGNFGG------------RGGY-GGGGGGSRGSY 260

  Fly   249 GYGNSGPGSYQGWGAPPGPQGPPPQWSNYAGPQQTQGYGGYDMYNSTSTGAP------SGPSGGG 307
            |   .|.|.|.|:|...|..|..|.:|:..      ||||         |.|      .|..|||
Human   261 G---GGDGGYNGFGGDGGNYGGGPGYSSRG------GYGG---------GGPGYGNQGGGYGGGG 307

  Fly   308 SWNSWNMPPNSAGPTGAPGAGAGTATDM--YSRAQAWATGGPSTTGPVGGMPRTGPGNSASKSGS 370
            .::.:|...|..|  |..| |.|...|.  || .|..:..||...|..||          ..|||
Human   308 GYDGYNEGGNFGG--GNYG-GGGNYNDFGNYS-GQQQSNYGPMKGGSFGG----------RSSGS 358

  Fly   371 EYDYGGYGSGYDYDYSNYVKQEGASNYGA 399
            .|. ||||||           .|:..||:
Human   359 PYG-GGYGSG-----------GGSGGYGS 375

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hrb27C	NP_476869.1	RRM1_hnRNPA_hnRNPD_like	9..80	CDD:409763	32/70 (46%)
		RRM2_DAZAP1	94..173	CDD:409765	28/82 (34%)
HNRNPA3	NP_919223.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..34		1/3 (33%)
		RRM1_hnRNPA_like	36..113	CDD:409992	35/76 (46%)
		RRM2_hnRNPA3	126..205	CDD:409996	27/78 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	204..225		4/20 (20%)
		HnRNPA1	331..>347	CDD:463312	6/16 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	336..378		20/63 (32%)