Protein Alignment x16 and SRSF1

DIOPT Version :10

• Sequence 1: NP_723226.1
• Gene: x16 / 33967
• FlyBaseID: FBgn0028554
• Length: 258
• Species: Drosophila melanogaster
• Sequence 2: NP_008855.1
• Gene: SRSF1 / 6426
• HGNCID: 10780
• Length: 248
• Species: Homo sapiens
• Alignment Length: 289
• Identity: 95/289 - (32%)
• Similarity: 113/289 - (39%)
• Gaps: 116/289 - (40%)

  Fly     6 SDRKVYVGDLGNNARKNDLEYVFGAYGSLRSVWI--ARNPPGFAFVEFESARDAADAVRGLDGRT 68
            :|.::|||:|..:.|..|:|.||..||::|.:.:  .|..|.|||||||..|||.|||.|.||..
Human    14 NDCRIYVGNLPPDIRTKDIEDVFYKYGAIRDIDLKNRRGGPPFAFVEFEDPRDAEDAVYGRDGYD 78

  Fly    69 VCGRRARVELSTGKYARSGGGGGGGGGGGGGGGLGGRDRGG------------------GGRGD- 114
            ..|.|.|||     :.|||.|.|.||||||||| ..|.|.|                  |...|
Human    79 YDGYRLRVE-----FPRSGRGTGRGGGGGGGGG-APRGRYGPPSRRSENRVVVSGLPPSGSWQDL 137

  Fly   115 --------DKCYE---CGGRG-----------HFARHCRERKARQRR-------------RSNSF 144
                    |.||.   ..|.|           :..|.....|.|...             ||.|:
Human   138 KDHMREAGDVCYADVYRDGTGVVEFVRKEDMTYAVRKLDNTKFRSHEGETAYIRVKVDGPRSPSY 202

  Fly   145 SRSRSTSR-RRRTRSKSGTRSRSRSAGSVGRRSGRSNGRDENGSASRYSDHERNGSGAVDSPPPP 208
            .||||.|| |.|:||:|.:||||.|                                       |
Human   203 GRSRSRSRSRSRSRSRSNSRSRSYS---------------------------------------P 228

  Fly   209 KRRYEDEDDDRVRGSPR-----SRSRSRS 232
            :|.         |||||     ||||||:
Human   229 RRS---------RGSPRYSPRHSRSRSRT 248

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
x16	NP_723226.1	RRM_SRSF3_like	9..81	CDD:409808	35/73 (48%)
SRSF1	NP_008855.1	RRM1_SRSF1	12..90	CDD:410010	36/80 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	88..134		18/46 (39%)
		RRM2_SRSF1	113..196	CDD:410160	11/82 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	191..248		31/104 (30%)
		Interaction with SAFB1	198..247		30/96 (31%)