DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment x16 and SRSF12

DIOPT Version :9

Sequence 1:	NP_723226.1	Gene:	x16 / 33967	FlyBaseID:	FBgn0028554	Length:	258	Species:	Drosophila melanogaster
Sequence 2:	NP_542781.3	Gene:	SRSF12 / 135295	HGNCID:	21220	Length:	261	Species:	Homo sapiens

Alignment Length:	281	Identity:	76/281 - (27%)
Similarity:	118/281 - (41%)	Gaps:	68/281 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSRH--PSDRKVYVGDLGNNARKNDLEYVFGAYGSLRSVWI-----ARNPPGFAFVEFESARDAA 58
            |||:  |.:..:::.::.:..|..||...||.||.:..|:|     .|.|.|||:|:||..|||.
Human     1 MSRYTRPPNTSLFIRNVADATRPEDLRREFGRYGPIVDVYIPLDFYTRRPRGFAYVQFEDVRDAE 65

  Fly    59 DAVRGLDGRTVCGRRARVELSTGKYARSGGGGGGGGGGGGGGGLGGRDRGGGGRGDDK-CYECGG 122
            ||:..|:.:.||||:..::.:.|                        ||...|:...| .:.|..
Human    66 DALYNLNRKWVCGRQIEIQFAQG------------------------DRKTPGQMKSKERHPCSP 106

  Fly   123 RGH------FARHCRERKA---RQRRRSNSF------------SRSRSTSRRRRTRSKSGTRSRS 166
            ..|      ..|..|.|.:   |.||||:|.            |:|||.|..||:.|...:|:..
Human   107 SDHRRSRSPSQRRTRSRSSSWGRNRRRSDSLKESRHRRFSYSQSKSRSKSLPRRSTSARQSRTPR 171

  Fly   167 RSAGSVGR--------------RSGRSNGRDENGSASRYSDHERNGSGAVDSPPPPKRRYEDEDD 217
            |:.||.||              :|..|:.:.:..|.::...|.|:......||....:.|.: .:
Human   172 RNFGSRGRSRSKSLQKRSKSIGKSQSSSPQKQTSSGTKSRSHGRHSDSIARSPCKSPKGYTN-SE 235

  Fly   218 DRVRGSPRSRSRSRSASPAVR 238
            .:|:.:..|..||.|.|.:.|
Human   236 TKVQTAKHSHFRSHSRSRSYR 256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
x16	NP_723226.1	RRM	<1..>82	CDD:223796	31/87 (36%)
x16	NP_723226.1	RRM_SRSF3_like	9..81	CDD:240819	27/76 (36%)
SRSF12	NP_542781.3	RRM_SRSF10_SRSF12	10..93	CDD:240758	30/106 (28%)
		PABP-1234	<12..211	CDD:130689	60/222 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	86..261		45/196 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1533297at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920