DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nop5 and NOP58

DIOPT Version :9

Sequence 1:	NP_477412.1	Gene:	nop5 / 33966	FlyBaseID:	FBgn0026196	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_014955.1	Gene:	NOP58 / 854487	SGDID:	S000005837	Length:	511	Species:	Saccharomyces cerevisiae

Alignment Length:	516	Identity:	241/516 - (46%)
Similarity:	342/516 - (66%)	Gaps:	17/516 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 FVLYETPAGYAIFKLLDEKKLEQVDNLYQEFETPEKANKLLKLKHFEKFNDTTEALAAATAAVEG 66
            :||.||.||||:.|..| ||:.:..:|.|:.::.:|..|..|:..|.|||....||..|.:.:||
Yeast     3 YVLTETSAGYALLKASD-KKIYKSSSLIQDLDSSDKVLKEFKIAAFSKFNSAANALEEANSIIEG 66

  Fly    67 KVAKPLKKTLKKLLVDDVQSSLLVADAKLGTAI-KDKLSVQCVCNTGVQELMRCIRQQADSLLGG 130
            ||:..|:|.|:: :..|.:|:|:|::.||..|| |..|:...|.:....::.|.|::....||.|
Yeast    67 KVSSQLEKLLEE-IKKDKKSTLIVSETKLANAINKLGLNFNVVSDAVTLDIYRAIKEYLPELLPG 130

  Fly   131 LPKREMTAMALGLAHSLSRYKLKFSPDKIDTMIVQAQCLLDDLDKELNNYMMRAREWYGWHFPEL 195
            :...:::.|:||||||:.|:|||||.||:|.||:||..||||||||||.|.||.:||||||||||
Yeast   131 MSDNDLSKMSLGLAHSIGRHKLKFSADKVDVMIIQAIALLDDLDKELNTYAMRCKEWYGWHFPEL 195

  Fly   196 GKIITDNIAFVKTIKLVGTRDNMATSDLSDILPEDVEEKVKEAAEISMGTEISEEDVLNIQCLCD 260
            .||:||::|:.:.|..:|.|...:.:|||:||||::||:||.|||:||||||::.|:.||..|.:
Yeast   196 AKIVTDSVAYARIILTMGIRSKASETDLSEILPEEIEERVKTAAEVSMGTEITQTDLDNINALAE 260

  Fly   261 EIISINDYRTHLYDYLKARMMAMAPNLTVLVGDTVGARLIAHAGSLINLAKHPSSTVQILGAEKA 325
            :|:....||..|.:||.|||.|:|||||.|||:.||||||||:||||:|||.|:||:||||||||
Yeast   261 QIVEFAAYREQLSNYLSARMKAIAPNLTQLVGELVGARLIAHSGSLISLAKSPASTIQILGAEKA 325

  Fly   326 LFRALKTKKDTPKYGLIYHAQLVGQASQKNKGKMSRSLAAKASLATRVDAFGEEA--TFELGAAH 388
            ||||||||.|||||||:|||.|||||:.|||||::|.|||||:::.|.||..|:.  :.::|...
Yeast   326 LFRALKTKHDTPKYGLLYHASLVGQATGKNKGKIARVLAAKAAVSLRYDALAEDRDDSGDIGLES 390

  Fly   389 KVKLESRLRLLEEGNLRKLSGTGKAKAKFEKYQAKSEVFTYQPEADNTLNVKKKRKHSESEQQTP 453
            :.|:|:||..||..:||......:...|.|..:|::    |..:||...........|:.|::..
Yeast   391 RAKVENRLSQLEGRDLRTTPKVVREAKKVEMTEARA----YNADADTAKAASDSESDSDDEEEEK 451

  Fly   454 VKKEE---PAEEEAEVKSEKKKKKKKKQKDEEVEAVEEAAAPEPEDQPTPAKKKKKSKHQE 511
            .:|:|   ..:::.:.|..||.||:||.|.|:.|..|:....|.::     ||:||||.::
Yeast   452 KEKKEKKRKRDDDEDSKDSKKAKKEKKDKKEKKEKKEKKEKKEKKE-----KKEKKSKKEK 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nop5	NP_477412.1	NOP5NT	2..>52	CDD:285382	20/49 (41%)
		NOSIC	163..214	CDD:197999	32/50 (64%)
		Nop	169..397	CDD:280047	141/229 (62%)
NOP58	NP_014955.1	NOP5NT	3..66	CDD:400464	24/63 (38%)
NOP58	NP_014955.1	SIK1	42..436	CDD:224415	203/398 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343029
Domainoid	1	1.000	289	1.000	Domainoid score	I238
eggNOG	1	0.900	-	-		E1_COG1498
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7024
Inparanoid	1	1.050	437	1.000	Inparanoid score	I266
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54819
OrthoFinder	1	1.000	-	-		FOG0004291
OrthoInspector	1	1.000	-	-		oto98937
orthoMCL	1	0.900	-	-		OOG6_101575
Panther	1	1.100	-	-	LDO	PTHR10894
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R831
SonicParanoid	1	1.000	-	-		X2530
TreeFam	1	0.960	-	-
	15	14.790