DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nop5 and Prpf31

DIOPT Version :9

Sequence 1:	NP_477412.1	Gene:	nop5 / 33966	FlyBaseID:	FBgn0026196	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_081604.3	Gene:	Prpf31 / 68988	MGIID:	1916238	Length:	499	Species:	Mus musculus

Alignment Length:	417	Identity:	95/417 - (22%)
Similarity:	178/417 - (42%)	Gaps:	98/417 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 KKTLKKLLVDDVQSSLLVADAKLGTAIKDKLSVQCVCNTGVQELMRCIRQQADSLLGGLPKREMT 137
            ::|...|..|.|:|...:.|:|:...|..|:.........|.|:|
Mouse    37 EETQLDLSGDSVKSIAKLWDSKMFAEIMMKIEEYISKQANVSEVM-------------------- 81

  Fly   138 AMALGLAHSLSRYKLKFSPDKIDTMIVQAQCLLDDLDKELNNYMMRAREWYGWHFPELGKIITDN 202
                |...:...|:          :||.|..|..:::.|||......|:.|...||||..::.:.
Mouse    82 ----GPVEAAPEYR----------VIVDANNLTVEIENELNIIHKFIRDKYSKRFPELESLVPNA 132

  Fly   203 IAFVKTIKLVGT-----RDNMATSDLSDILPEDVEEKVKEAAEISMGTEISEEDVLNIQCLCDEI 262
            :.:::|:|.:|.     ::|   .:|..||.......|...|..:.|.::|:|::..::..||..
Mouse   133 LDYIRTVKELGNSLDKCKNN---ENLQQILTNATIMVVSVTASTTQGQQLSDEELERLEEACDMA 194

  Fly   263 ISINDYRTHLYDYLKARMMAMAPNLTVLVGDTVGARLIAHAGSLINLAKHPSSTVQILGAEKALF 327
            :.:|..:..:|:|:::||..:||||::::|.:..|:::..||.|.||:|.|:..:.:|||::...
Mouse   195 LELNASKHRIYEYVESRMSFIAPNLSIIIGASTAAKIMGVAGGLTNLSKMPACNIMLLGAQRKTL 259

  Fly   328 RALKTKKDTPKYGLIYHAQLVGQASQKNKGKMSRSLAAKASLATRVDAFGEEATFELGAAHKVKL 392
            ....:....|..|.|||:.:|.......:.|.:|.:|||.:||.|||:|.|....::|
Mouse   260 SGFSSTSVLPHTGYIYHSDIVQSLPPDLRRKAARLVAAKCTLAARVDSFHESTEGKVG------- 317

  Fly   393 ESRLRLLEEGNLRKLSGTGKAKAKFEKYQAKSEVFTYQPEADNTLNVKKKRKHSESEQQTPVKKE 457
                                       |:.|.|:               :||..:.::..|||:.
Mouse   318 ---------------------------YELKDEI---------------ERKFDKWQEPPPVKQV 340

  Fly   458 EPAEEEAEVKSEKKKK-----KKKKQK 479
            :|.  .|.:..::||:     :|.|::
Mouse   341 KPL--PAPLDGQRKKRGGRRYRKMKER 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nop5	NP_477412.1	NOP5NT	2..>52	CDD:285382
		NOSIC	163..214	CDD:197999	15/50 (30%)
		Nop	169..397	CDD:280047	64/232 (28%)
Prpf31	NP_081604.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43		1/5 (20%)
		NOSIC	93..144	CDD:197999	15/50 (30%)
		Nop	99..329	CDD:280047	69/281 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	334..357		7/24 (29%)
		Prp31_C	337..465	CDD:286825	8/31 (26%)
		Nuclear localization signal (NLS). /evidence=ECO:0000250\|UniProtKB:Q8WWY3	351..364		3/12 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1498
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810