DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nop5 and Nop58

DIOPT Version :9

Sequence 1:	NP_477412.1	Gene:	nop5 / 33966	FlyBaseID:	FBgn0026196	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_068522.1	Gene:	Nop58 / 60373	RGDID:	620484	Length:	534	Species:	Rattus norvegicus

Alignment Length:	538	Identity:	325/538 - (60%)
Similarity:	398/538 - (73%)	Gaps:	32/538 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFVLYETPAGYAIFKLLDEKKLEQVDNLYQEFETPEKANKLLKLKHFEKFNDTTEALAAATAAVE 65
            |.||:||..||||||:|:||||::||:|::||||||||||::||||||||.||.|||||.||.:|
  Rat     1 MLVLFETSVGYAIFKVLNEKKLQEVDSLWKEFETPEKANKIVKLKHFEKFQDTAEALAAFTALME 65

  Fly    66 GKVAKPLKKTLKKLLVDDVQSSLLVADAKLGTAIKDKLSVQCVCNTGVQELMRCIRQQADSLLGG 130
            ||:.|.|||.||| :|.:....|.|||||||..||:||::.|:.:..|.||||.||.|.|.|:.|
  Rat    66 GKINKQLKKVLKK-IVKEAHEPLAVADAKLGGVIKEKLNLSCIHSPVVNELMRGIRSQMDGLIPG 129

  Fly   131 LPKREMTAMALGLAHSLSRYKLKFSPDKIDTMIVQAQCLLDDLDKELNNYMMRAREWYGWHFPEL 195
            :..|||.||.||||||||||:||||.||:|||||||..||||||||||||:||.|||||||||||
  Rat   130 VEPREMAAMCLGLAHSLSRYRLKFSADKVDTMIVQAISLLDDLDKELNNYIMRCREWYGWHFPEL 194

  Fly   196 GKIITDNIAFVKTIKLVGTRDNMATSDLSDILPEDVEEKVKEAAEISMGTEISEEDVLNIQCLCD 260
            ||||:||:.:.|.::.||.|.|.|::.||:.|.|:||.:||.|||||||||:||||:.||..||.
  Rat   195 GKIISDNLTYCKCLQKVGDRKNYASATLSEFLSEEVEAEVKAAAEISMGTEVSEEDICNILHLCT 259

  Fly   261 EIISINDYRTHLYDYLKARMMAMAPNLTVLVGDTVGARLIAHAGSLINLAKHPSSTVQILGAEKA 325
            ::|.|::|||.||:||:.||||:|||:||:||:.||||||||||||:|||||.:|||||||||||
  Rat   260 QVIEISEYRTQLYEYLQNRMMAIAPNVTVMVGELVGARLIAHAGSLLNLAKHAASTVQILGAEKA 324

  Fly   326 LFRALKTKKDTPKYGLIYHAQLVGQASQKNKGKMSRSLAAKASLATRVDAFGEEATFELGAAHKV 390
            ||||||:::|||||||||||.||||.|.|:|||:||.||||..||.|.|||||:::..:||.::.
  Rat   325 LFRALKSRRDTPKYGLIYHASLVGQTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGAENRA 389

  Fly   391 KLESRLRLLEEGNLRKLSGTGKAKAKFEKYQAKSEVFTYQPEADNTL-NVKKKRKHSE------- 447
            |||:|||:||:..:||:||||||.||.|||:.||||.||.|..|:|| ...||||..|
  Rat   390 KLEARLRILEDRGIRKISGTGKALAKAEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEEVDKEDEI 454

  Fly   448 ----------------SEQQTPVKKEEPAEEEAEVKSEKKKKKKKKQKDE---EVEAVEEAAAPE 493
                            .|:....::|:..|||..||.:|||.|||..|:|   |.|.....|.|.
  Rat   455 TEKKAKKAKIKIKAEVEEEMEEAEEEQVVEEEPTVKKKKKKDKKKHIKEEPLSEEEPCTSTAVPS 519

  Fly   494 PEDQPTPAKKKKKSKHQE 511
            ||.:    |||||.|..|
  Rat   520 PEKK----KKKKKKKDAE 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nop5	NP_477412.1	NOP5NT	2..>52	CDD:285382	36/49 (73%)
		NOSIC	163..214	CDD:197999	37/50 (74%)
		Nop	169..397	CDD:280047	156/227 (69%)
Nop58	NP_068522.1	NOP5NT	2..66	CDD:400464	45/63 (71%)
		Nop	169..396	CDD:396390	155/226 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	470..534		28/68 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338175
Domainoid	1	1.000	325	1.000	Domainoid score	I1163
eggNOG	1	0.900	-	-		E1_COG1498
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7024
Inparanoid	1	1.050	610	1.000	Inparanoid score	I885
OMA	1	1.010	-	-		QHG54819
OrthoDB	1	1.010	-	-		D261881at33208
OrthoFinder	1	1.000	-	-		FOG0004291
OrthoInspector	1	1.000	-	-		oto95467
orthoMCL	1	0.900	-	-		OOG6_101575
Panther	1	1.100	-	-	LDO	PTHR10894
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2530
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770