DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nop5 and Nop58

DIOPT Version :9

Sequence 1:	NP_477412.1	Gene:	nop5 / 33966	FlyBaseID:	FBgn0026196	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_061356.2	Gene:	Nop58 / 55989	MGIID:	1933184	Length:	536	Species:	Mus musculus

Alignment Length:	540	Identity:	328/540 - (60%)
Similarity:	402/540 - (74%)	Gaps:	34/540 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFVLYETPAGYAIFKLLDEKKLEQVDNLYQEFETPEKANKLLKLKHFEKFNDTTEALAAATAAVE 65
            |.||:||..||||||:|:||||::||:|::||||||||||::||||||||.||.|||||.||.:|
Mouse     1 MLVLFETSVGYAIFKVLNEKKLQEVDSLWKEFETPEKANKIVKLKHFEKFQDTAEALAAFTALME 65

  Fly    66 GKVAKPLKKTLKKLLVDDVQSSLLVADAKLGTAIKDKLSVQCVCNTGVQELMRCIRQQADSLLGG 130
            ||:.|.|||.||| :|.:....|.|||||||..||:||::.|:.:..|.||||.||.|.|.|:.|
Mouse    66 GKINKQLKKVLKK-IVKEAHEPLAVADAKLGGVIKEKLNLSCIHSPVVNELMRGIRSQMDGLIPG 129

  Fly   131 LPKREMTAMALGLAHSLSRYKLKFSPDKIDTMIVQAQCLLDDLDKELNNYMMRAREWYGWHFPEL 195
            :..|||.||.||||||||||:||||.||:|||||||..||||||||||||:||.|||||||||||
Mouse   130 VEPREMAAMCLGLAHSLSRYRLKFSADKVDTMIVQAISLLDDLDKELNNYIMRCREWYGWHFPEL 194

  Fly   196 GKIITDNIAFVKTIKLVGTRDNMATSDLSDILPEDVEEKVKEAAEISMGTEISEEDVLNIQCLCD 260
            ||||:||:.:.|.::.||.|.|.|::.||:.|.|:||.:||.|||||||||:||||:.||..||.
Mouse   195 GKIISDNLTYCKCLQKVGDRKNYASASLSEFLSEEVEAEVKAAAEISMGTEVSEEDICNILHLCT 259

  Fly   261 EIISINDYRTHLYDYLKARMMAMAPNLTVLVGDTVGARLIAHAGSLINLAKHPSSTVQILGAEKA 325
            ::|.|::|||.||:||:.||||:|||:||:||:.||||||||||||:|||||.:|||||||||||
Mouse   260 QVIEISEYRTQLYEYLQNRMMAIAPNVTVMVGELVGARLIAHAGSLLNLAKHAASTVQILGAEKA 324

  Fly   326 LFRALKTKKDTPKYGLIYHAQLVGQASQKNKGKMSRSLAAKASLATRVDAFGEEATFELGAAHKV 390
            ||||||:::|||||||||||.||||:|.|:|||:||.||||..||.|.|||||:::..:|..::.
Mouse   325 LFRALKSRRDTPKYGLIYHASLVGQSSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGIENRA 389

  Fly   391 KLESRLRLLEEGNLRKLSGTGKAKAKFEKYQAKSEVFTYQPEADNTL-NVKKKRKHSESEQQTPV 454
            |||:|||:||:..:||:||||||.||.|||:.||||.||.|..|:|| ...||||..|.:::..:
Mouse   390 KLEARLRILEDRGIRKISGTGKALAKAEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEEVDKEDEI 454

  Fly   455 -----KK----------EEPAEEEAE----------VKSEKKKKKKKKQKDE---EVEAVEEAAA 491
                 ||          ||..|||||          ||.:|||.|||..|:|   |.|.....|.
Mouse   455 TEKKAKKAKIKIKAEVEEEMEEEEAEEEQVVEEEPTVKKKKKKDKKKHIKEEPLSEEEPCTSTAV 519

  Fly   492 PEPEDQPTPAKKKKKSKHQE 511
            |.||.:    |||||.|..|
Mouse   520 PSPEKK----KKKKKKKDAE 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nop5	NP_477412.1	NOP5NT	2..>52	CDD:285382	36/49 (73%)
		NOSIC	163..214	CDD:197999	37/50 (74%)
		Nop	169..397	CDD:280047	155/227 (68%)
Nop58	NP_061356.2	NOP5NT	2..66	CDD:285382	45/63 (71%)
		NOSIC	162..213	CDD:197999	37/50 (74%)
		Nop	168..396	CDD:280047	155/227 (68%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	414..440		15/25 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	470..536		30/70 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834595
Domainoid	1	1.000	324	1.000	Domainoid score	I1201
eggNOG	1	0.900	-	-		E1_COG1498
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7024
Inparanoid	1	1.050	609	1.000	Inparanoid score	I920
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54819
OrthoDB	1	1.010	-	-		D261881at33208
OrthoFinder	1	1.000	-	-		FOG0004291
OrthoInspector	1	1.000	-	-		oto91891
orthoMCL	1	0.900	-	-		OOG6_101575
Panther	1	1.100	-	-	LDO	PTHR10894
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R831
SonicParanoid	1	1.000	-	-		X2530
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.840