Protein Alignment nop5 and NOP58

DIOPT Version :10

• Sequence 1: NP_477412.1
• Gene: nop5 / 33966
• FlyBaseID: FBgn0026196
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: NP_057018.1
• Gene: NOP58 / 51602
• HGNCID: 29926
• Length: 529
• Species: Homo sapiens
• Alignment Length: 537
• Identity: 323/537 - (60%)
• Similarity: 399/537 - (74%)
• Gaps: 37/537 - (6%)

  Fly     1 MFVLYETPAGYAIFKLLDEKKLEQVDNLYQEFETPEKANKLLKLKHFEKFNDTTEALAAATAAVE 65
            |.||:||..||||||:|:||||::||:|::||||||||||::||||||||.||.|||||.||.:|
Human     1 MLVLFETSVGYAIFKVLNEKKLQEVDSLWKEFETPEKANKIVKLKHFEKFQDTAEALAAFTALME 65

  Fly    66 GKVAKPLKKTLKKLLVDDVQSSLLVADAKLGTAIKDKLSVQCVCNTGVQELMRCIRQQADSLLGG 130
            ||:.|.|||.||| :|.:....|.|||||||..||:||::.|:.:..|.||||.||.|.|.|:.|
Human    66 GKINKQLKKVLKK-IVKEAHEPLAVADAKLGGVIKEKLNLSCIHSPVVNELMRGIRSQMDGLIPG 129

  Fly   131 LPKREMTAMALGLAHSLSRYKLKFSPDKIDTMIVQAQCLLDDLDKELNNYMMRAREWYGWHFPEL 195
            :..|||.||.||||||||||:||||.||:|||||||..||||||||||||:||.|||||||||||
Human   130 VEPREMAAMCLGLAHSLSRYRLKFSADKVDTMIVQAISLLDDLDKELNNYIMRCREWYGWHFPEL 194

  Fly   196 GKIITDNIAFVKTIKLVGTRDNMATSDLSDILPEDVEEKVKEAAEISMGTEISEEDVLNIQCLCD 260
            ||||:||:.:.|.::.||.|.|.|::.||::|||:||.:||.|||||||||:||||:.||..||.
Human   195 GKIISDNLTYCKCLQKVGDRKNYASAKLSELLPEEVEAEVKAAAEISMGTEVSEEDICNILHLCT 259

  Fly   261 EIISINDYRTHLYDYLKARMMAMAPNLTVLVGDTVGARLIAHAGSLINLAKHPSSTVQILGAEKA 325
            ::|.|::|||.||:||:.||||:|||:||:||:.||||||||||||:|||||.:|||||||||||
Human   260 QVIEISEYRTQLYEYLQNRMMAIAPNVTVMVGELVGARLIAHAGSLLNLAKHAASTVQILGAEKA 324

  Fly   326 LFRALKTKKDTPKYGLIYHAQLVGQASQKNKGKMSRSLAAKASLATRVDAFGEEATFELGAAHKV 390
            ||||||:::|||||||||||.||||.|.|:|||:||.||||..||.|.|||||:::..:|..::.
Human   325 LFRALKSRRDTPKYGLIYHASLVGQTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRA 389

  Fly   391 KLESRLRLLEEGNLRKLSGTGKAKAKFEKYQAKSEVFTYQPEADNTL-NVKKKRK--HSESEQQT 452
            |||:|||.||:..:||:||||||.||.|||:.||||.||.|..|:|| ...||||  ..:.|.:.
Human   390 KLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEI 454

  Fly   453 PVKKEEPA----------------EEEAEVKSEKKKKKKKKQKDEEVEAVEEAAAPEPEDQP--- 498
            ..||.:.|                |||..||.:||:.|||..|:|          |..|::|
Human   455 TEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEE----------PLSEEEPCTS 509

  Fly   499 ----TPAKKKKKSKHQE 511
                :|.|||||.|.:|
Human   510 TAIASPEKKKKKKKKRE 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nop5	NP_477412.1	NOP5NT	2..>52	CDD:462382	36/49 (73%)
		Nop	170..397	CDD:460335	155/226 (69%)
NOP58	NP_057018.1	NOP5NT	2..66	CDD:462382	45/63 (71%)
		Sufficient for interaction with NOPCHAP1. /evidence=ECO:0000269|PubMed:33367824	155..400		168/244 (69%)
		Nop	169..396	CDD:460335	155/226 (69%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	409..529		50/128 (39%)