DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nop5 and prpf31

DIOPT Version :9

Sequence 1:	NP_477412.1	Gene:	nop5 / 33966	FlyBaseID:	FBgn0026196	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_956798.1	Gene:	prpf31 / 393476	ZFINID:	ZDB-GENE-040426-1561	Length:	508	Species:	Danio rerio

Alignment Length:	316	Identity:	84/316 - (26%)
Similarity:	151/316 - (47%)	Gaps:	29/316 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 MIVQAQCLLDDLDKELNNYMMRAREWYGWHFPELGKIITDNIAFVKTIKLVGTRDNMATSD--LS 224
            :||.|..|..::|.|||......|:.|...||||..::.:.:.:::|:|.:|.......::  |.
Zfish   103 LIVAANNLTVEIDNELNIIHKFVRDKYSKRFPELESLVPNALDYIRTVKELGNNLEKCKNNETLQ 167

  Fly   225 DILPEDVEEKVKEAAEISMGTEISEEDVLNIQCLCDEIISINDYRTHLYDYLKARMMAMAPNLTV 289
            .||.......|...|..:.||.:.::::..::..||..:.:|..:..:|:|:::||..:||||::
Zfish   168 QILTNATIMVVSVTASTTQGTMLGDDELQRLEEACDMALELNQSKHRIYEYVESRMSFIAPNLSI 232

  Fly   290 LVGDTVGARLIAHAGSLINLAKHPSSTVQILGAEKALFRALKTKKDTPKYGLIYHAQLVGQASQK 354
            :||.:..|:::..||.|.||:|.|:..:.:|||::.......:....|..|.|||..:|......
Zfish   233 IVGASTAAKIMGVAGGLTNLSKMPACNLMLLGAQRRTLSGFSSTSLLPHTGYIYHCDVVQTLPPD 297

  Fly   355 NKGKMSRSLAAKASLATRVDAFGEEATFELGAAHKVKLESRLRLLEEGNLRKLSGTGKAKAKFEK 419
            .:.|.:|.::||.:||:|||:|.|.|..::|...|.::|                     .||:|
Zfish   298 LRRKAARLVSAKCTLASRVDSFHESADGKVGYDLKEEIE---------------------RKFDK 341

  Fly   420 YQAKSEVFTYQPEADNTLNVKKK------RKHSESEQQTPVKKEEPAEEEAEVKSE 469
            :|....|...:|........:||      ||..|....|.::|.......||::.:
Zfish   342 WQEPPPVKQVKPLPAPLDGQRKKRGGRRYRKMKERLGLTEIRKHANRMTFAEIEDD 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nop5	NP_477412.1	NOP5NT	2..>52	CDD:285382
		NOSIC	163..214	CDD:197999	16/50 (32%)
		Nop	169..397	CDD:280047	66/229 (29%)
prpf31	NP_956798.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..45
		NOSIC	104..155	CDD:197999	16/50 (32%)
		Nop	110..340	CDD:280047	67/250 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	345..368		4/22 (18%)
		Prp31_C	348..476	CDD:286825	11/50 (22%)
		Nuclear localization signal (NLS). /evidence=ECO:0000250\|UniProtKB:Q8WWY3	362..375		4/12 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	442..461
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1498
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810