DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nop5 and Nop56

DIOPT Version :9

Sequence 1:	NP_477412.1	Gene:	nop5 / 33966	FlyBaseID:	FBgn0026196	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_001020903.1	Gene:	Nop56 / 362214	RGDID:	1308892	Length:	588	Species:	Rattus norvegicus

Alignment Length:	567	Identity:	211/567 - (37%)
Similarity:	312/567 - (55%)	Gaps:	64/567 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFVLYETPAGYAIFKLLDEKKLEQVDNLYQEFE----TPEKANKLLKLKHFEKFNDTTEALAAAT 61
            :.||:|...|||:..|   |::|::..|..:.|    ...|.:.:::|..|..|:.:..||..|.
  Rat     4 LHVLFEHAVGYALLAL---KEVEEISLLLPQVEECVLNLGKFHNVVRLVAFCPFSSSQVALENAN 65

  Fly    62 AAVEGKVAKPLKKTLKKLLVDDVQSSLL-VADAKLGTAIKDKLSVQCVCNTGVQELMRCIRQQAD 125
            |..||.|.:.|:..|:..|....:..|| |.|.|:|.||:::|...|.....:.|::|.:|....
  Rat    66 AVSEGVVHEDLRLLLETYLPSKKKKVLLGVGDPKIGAAIQEELGYNCQTGGVIAEILRGVRLHFH 130

  Fly   126 SLLGGLPKREMTAMALGLAHSLSRYKLKFSPDKIDTMIVQAQCLLDDLDKELNNYMMRAREWYGW 190
            :|:.||.........|||.||.||.|:||:.:::|.||:|:..|||.|||::|.:.||.|||||:
  Rat   131 NLVKGLTDLSACKAQLGLGHSYSRAKVKFNVNRVDNMIIQSISLLDQLDKDINTFSMRVREWYGY 195

  Fly   191 HFPELGKIITDNIAFVKTIKLVGTRDNM---ATSDLSDILPEDVEEK-VKEAAEISMGTEISEED 251
            |||||.|||.||..:.:..:.:|.|..:   ....|.:|..:..:.| :.:|:..|||.:||..|
  Rat   196 HFPELVKIINDNATYCRLAQFIGNRRELNEEKLEKLEEITMDGAKAKAILDASRSSMGMDISAID 260

  Fly   252 VLNIQCLCDEIISINDYRTHLYDYLKARMMAMAPNLTVLVGDTVGARLIAHAGSLINLAKHPSST 316
            ::||:.....::|:::||..|::||:::|..:||:|:.|:|:.||||||||||||.||||:|:||
  Rat   261 LINIESFSSRVVSLSEYRQSLHNYLRSKMSQVAPSLSALIGEAVGARLIAHAGSLTNLAKYPAST 325

  Fly   317 VQILGAEKALFRALKTKKDTPKYGLIYHAQLVGQASQKNKGKMSRSLAAKASLATRVDAFGEEAT 381
            ||||||||||||||||:.:|||||||:|:..:|:|:.||||::||.||.|.|:|:|:|.|.|..|
  Rat   326 VQILGAEKALFRALKTRGNTPKYGLIFHSTFIGRAAAKNKGRISRYLANKCSIASRIDCFSEVPT 390

  Fly   382 FELGAAHKVKLESRLRLLEEGNL-----------------------RKLSGTGKAKAKFEKYQ-- 421
            ...|...:.::|.||...|.|.:                       |||....|.:.|.||.:
  Rat   391 SVFGEKLREQVEERLSFYETGEIPRKNLDVMKEAVVQAEEAAAEITRKLEKQEKKRLKKEKKRLA 455

  Fly   422 ----AKSEVFTYQPEADNTLNVKKKRKHSESEQQTPVKKEEPAEEEAEVKSEKKKKKKKKQKDEE 482
                |.|| .:..||....:|.|.|:|..:.::..    :|...|:..|...|.||||...|:|.
  Rat   456 ALALASSE-NSSTPEECEEVNEKPKKKKLKPQETL----QENGMEDPPVSLPKTKKKKAFPKEEL 515

  Fly   483 VEAVEEAA------------------APEPEDQPTPAKKKKKSKHQE 511
            ...:||.|                  |.|||:..:|...|||.|..|
  Rat   516 ASDLEEMATSSISVPKKKKSLPKEEVASEPEEAASPITPKKKRKFSE 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nop5	NP_477412.1	NOP5NT	2..>52	CDD:285382	15/53 (28%)
		NOSIC	163..214	CDD:197999	26/50 (52%)
		Nop	169..397	CDD:280047	114/231 (49%)
Nop56	NP_001020903.1	NOP5NT	5..70	CDD:285382	19/67 (28%)
		SIK1	48..416	CDD:224415	160/367 (44%)
		NOSIC	168..219	CDD:197999	26/50 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1498
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D261881at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820