DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nop5 and PRPF31

DIOPT Version :9

Sequence 1:	NP_477412.1	Gene:	nop5 / 33966	FlyBaseID:	FBgn0026196	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_056444.3	Gene:	PRPF31 / 26121	HGNCID:	15446	Length:	499	Species:	Homo sapiens

Alignment Length:	358	Identity:	85/358 - (23%)
Similarity:	163/358 - (45%)	Gaps:	72/358 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 LPKREMTAMALGLAHSLSRYKLKFSPDKIDTMIVQAQCLLDDLDKELNNYMMRAREWYGWHFPEL 195
            :.|:...:..:|...:...|:          :||.|..|..:::.|||......|:.|...||||
Human    71 ISKQAKASEVMGPVEAAPEYR----------VIVDANNLTVEIENELNIIHKFIRDKYSKRFPEL 125

  Fly   196 GKIITDNIAFVKTIKLVGT-----RDNMATSDLSDILPEDVEEKVKEAAEISMGTEISEEDVLNI 255
            ..::.:.:.:::|:|.:|.     ::|   .:|..||.......|...|..:.|.::|||::..:
Human   126 ESLVPNALDYIRTVKELGNSLDKCKNN---ENLQQILTNATIMVVSVTASTTQGQQLSEEELERL 187

  Fly   256 QCLCDEIISINDYRTHLYDYLKARMMAMAPNLTVLVGDTVGARLIAHAGSLINLAKHPSSTVQIL 320
            :..||..:.:|..:..:|:|:::||..:||||::::|.:..|:::..||.|.||:|.|:..:.:|
Human   188 EEACDMALELNASKHRIYEYVESRMSFIAPNLSIIIGASTAAKIMGVAGGLTNLSKMPACNIMLL 252

  Fly   321 GAEKALFRALKTKKDTPKYGLIYHAQLVGQASQKNKGKMSRSLAAKASLATRVDAFGEEATFELG 385
            ||::.......:....|..|.|||:.:|.......:.|.:|.:|||.:||.|||:|.|....::|
Human   253 GAQRKTLSGFSSTSVLPHTGYIYHSDIVQSLPPDLRRKAARLVAAKCTLAARVDSFHESTEGKVG 317

  Fly   386 AAHKVKLESRLRLLEEGNLRKLSGTGKAKAKFEKYQAKSEVFTYQPEADNTLNVKKKRKHSESEQ 450
                                              |:.|.|:               :||..:.::
Human   318 ----------------------------------YELKDEI---------------ERKFDKWQE 333

  Fly   451 QTPVKKEEPAEEEAEVKSEKKK---KKKKKQKD 480
            ..|||:.:|.  .|.:..::||   ::.:|.|:
Human   334 PPPVKQVKPL--PAPLDGQRKKRGGRRYRKMKE 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nop5	NP_477412.1	NOP5NT	2..>52	CDD:285382
		NOSIC	163..214	CDD:197999	15/50 (30%)
		Nop	169..397	CDD:280047	65/232 (28%)
PRPF31	NP_056444.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37
		Nop	100..330	CDD:396390	69/281 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	334..357		7/24 (29%)
		Prp31_C	337..465	CDD:401657	8/30 (27%)
		Nuclear localization signal (NLS). /evidence=ECO:0000269\|PubMed:12444105	351..364		3/12 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1498
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810