DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nop5 and nol-58

DIOPT Version :9

Sequence 1:	NP_477412.1	Gene:	nop5 / 33966	FlyBaseID:	FBgn0026196	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_001380042.1	Gene:	nol-58 / 171901	WormBaseID:	WBGene00020915	Length:	487	Species:	Caenorhabditis elegans

Alignment Length:	496	Identity:	280/496 - (56%)
Similarity:	353/496 - (71%)	Gaps:	17/496 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFVLYETPAGYAIFKLLDEKKLEQVDNLYQEFETPEKANKLLKLKHFEKFNDTTEALAAATAAVE 65
            |.||:|..||||:|||.:||||:.|||:::||.|.|||.:.|:|..|:||..|..|:.|.:...|
Worm     1 MLVLFEVAAGYAVFKLSNEKKLKNVDNIWEEFSTAEKAQENLQLVSFKKFKTTAGAVEATSEITE 65

  Fly    66 GKVAKPLKKTLKKLLVDDVQSSLLVADAKLGTAIKDKLSVQCVCNTGVQELMRCIRQQADSLLGG 130
            ||::|.|||.||. .||:.: .|.|.|||||..||:|||:.||.::.:.||||.:|...:.||..
Worm    66 GKLSKTLKKLLKS-SVDETE-KLAVGDAKLGNLIKEKLSLNCVHDSSINELMRGVRAHIEDLLAE 128

  Fly   131 LPKREMTAMALGLAHSLSRYKLKFSPDKIDTMIVQAQCLLDDLDKELNNYMMRAREWYGWHFPEL 195
             .|.||.||.|.:||||:|||:||:|:|||||||||..||||||||||||:||.|||||||||||
Worm   129 -HKEEMNAMNLAVAHSLARYKVKFNPEKIDTMIVQAVSLLDDLDKELNNYVMRVREWYGWHFPEL 192

  Fly   196 GKIITDNIAFVKTIKLVGTRDNMATSDLSDILPEDVEEKVKEAAEISMGTEISEEDVLNIQCLCD 260
            ||.|.|:.|:.|.||.:|.|.|...:|||.||||::||||||.|||||||:||:.|:::|:.|||
Worm   193 GKTIQDHQAYAKIIKAIGMRQNCINTDLSSILPEELEEKVKEDAEISMGTDISDIDLIHIKGLCD 257

  Fly   261 EIISINDYRTHLYDYLKARMMAMAPNLTVLVGDTVGARLIAHAGSLINLAKHPSSTVQILGAEKA 325
            ::|.::.||..|:||||.||.|:|||||||:|:.||||||:|||||::|||.|:||:||||||||
Worm   258 QVIELSAYRAQLFDYLKNRMTALAPNLTVLLGELVGARLISHAGSLVSLAKAPASTIQILGAEKA 322

  Fly   326 LFRALKTKKDTPKYGLIYHAQLVGQASQKNKGKMSRSLAAKASLATRVDAFGEE-ATFELGAAHK 389
            ||||||||||||||||||||||:.||..|.||||:|.||||.|||||:||..:| ||.|:|...:
Worm   323 LFRALKTKKDTPKYGLIYHAQLITQAPPKVKGKMARKLAAKCSLATRIDALSDESATNEIGIECR 387

  Fly   390 VKLESRLRLLEEGNLRKLSGTGKAKA----KFEKYQAKSEVFTYQPEADNTLNVKKKRKHSESEQ 450
            ..||:.||...|      .|..|.|:    :.:||:.|||.:.|...||...:.|.||.....|.
Worm   388 AALENVLRTESE------RGPSKNKSFGSHRHDKYEFKSETYEYDASADTPASRKHKRFDDNEES 446

  Fly   451 QTPVKKE--EPAEEEAEVKSEKKKKKK-KKQKDEEVEAVEE 488
            ...:||.  |..:||.|.:.||||||| ||.|..:.::.||
Worm   447 TNAIKKMKIEEVKEEDEAEPEKKKKKKEKKAKKADTDSDEE 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nop5	NP_477412.1	NOP5NT	2..>52	CDD:285382	28/49 (57%)
		NOSIC	163..214	CDD:197999	37/50 (74%)
		Nop	169..397	CDD:280047	155/228 (68%)
nol-58	NP_001380042.1	NOP5NT	2..66	CDD:400464	31/63 (49%)
nol-58	NP_001380042.1	SIK1	42..404	CDD:224415	224/370 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158278
Domainoid	1	1.000	312	1.000	Domainoid score	I712
eggNOG	1	0.900	-	-		E1_COG1498
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7024
Inparanoid	1	1.050	511	1.000	Inparanoid score	I712
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54819
OrthoDB	1	1.010	-	-		D261881at33208
OrthoFinder	1	1.000	-	-		FOG0004291
OrthoInspector	1	1.000	-	-		oto17795
orthoMCL	1	0.900	-	-		OOG6_101575
Panther	1	1.100	-	-	LDO	PTHR10894
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R831
SonicParanoid	1	1.000	-	-		X2530
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.840