DRSC/TRiP Functional Genomics Resources

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Protein Alignment Wee1 and EIF2AK3

DIOPT Version :9

Sequence 1:NP_001260167.1 Gene:Wee1 / 33965 FlyBaseID:FBgn0011737 Length:609 Species:Drosophila melanogaster
Sequence 2:NP_004827.4 Gene:EIF2AK3 / 9451 HGNCID:3255 Length:1116 Species:Homo sapiens


Alignment Length:630 Identity:118/630 - (18%)
Similarity:175/630 - (27%) Gaps:327/630 - (51%)


- Green bases have known domain annotations that are detailed below.


  Fly   174 KKRCRTQFGRENLNLNVNAMQKYLLSDACDDDVTEEAGD-SMREIHQQAPKRLALHDTNISRFKR 237
            :|...||...||         ||       |.|:.||.| |..:|....         .|||:..
Human   552 RKESETQCQTEN---------KY-------DSVSGEANDSSWNDIKNSG---------YISRYLT 591

  Fly   238 EFMQVNVIGVGEFGVVFQCVNRLDGCIYAIKKSKKPVAGSSFEKRALNEVWAHAVLGKHDNVVRY 302
            :|..:..:|.|.|||||:..|::|.|.||||:.:.|....:.|| .:.||.|.|.| :|..:|||
Human   592 DFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREK-VMREVKALAKL-EHPGIVRY 654

  Fly   303 YSAWAED---------------------------------------------------------- 309
            ::||.|.                                                          
Human   655 FNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRS 719

  Fly   310 ---------------------------DH------------------------------------ 311
                                       ||                                    
Human   720 RSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHS 784

  Fly   312 ---------------------MLIQNEFCDGGS---------LHARIQDHCL------------- 333
                                 ::.::..||..|         ||  |.:||.             
Human   785 FELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLH--IGNHCANKLTAFKPTSSKS 847

  Fly   334 -GEAELKI--------------------------------------------------------- 340
             .||.|.|                                                         
Human   848 SSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERS 912

  Fly   341 ----VLMHVIEGLRYIHSNDLVHMDLKPENIFSTMNPNAHKLVEVQPQQTKDDDGMDSVYEELRH 401
                :.:.:.|.:.::||..|:|.||||.|||.||                 ||           
Human   913 VCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTM-----------------DD----------- 949

  Fly   402 SENLVTYKIGDLGHVTSVKEPYVEE----------------GDCRYLPKEILH-EDYSNLFKADI 449
                 ..|:||.|.||::.:...|:                |...|:..|.:| ..||:  |.||
Human   950 -----VVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSH--KVDI 1007

  Fly   450 FSLGITLFEAAGGGPLPKNGPEWHNLRDGKVPILPSLSRDFNE-------LIAQMMHPYPDKRPT 507
            ||||:.|||..  .|..........|.|.:....|.|   |.:       ::..|:.|.|.:||.
Human  1008 FSLGLILFELL--YPFSTQMERVRTLTDVRNLKFPPL---FTQKYPCEYVMVQDMLSPSPMERPE 1067

  Fly   508 SQSIFSHPILSAVDSKSKLQLGLELTVEKRKNEILMNKLREAKKQ 552
            :.:|..:.:...:|...|       ||.::::..|.:...:..:|
Human  1068 AINIIENAVFEDLDFPGK-------TVLRQRSRSLSSSGTKHSRQ 1105

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Wee1NP_001260167.1 PTKc_Wee1 238..516 CDD:270953 95/527 (18%)
Pkinase 239..515 CDD:278497 95/525 (18%)
EIF2AK3NP_004827.4 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 77..101
Luminal_EIF2AK3 104..420 CDD:188874
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 550..571 9/34 (26%)
PKc_like 587..>663 CDD:304357 32/77 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 841..863 4/21 (19%)
STKc_EIF2AK3_PERK <873..1075 CDD:270950 51/241 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1090..1116 2/16 (13%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165158334
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.930

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