Protein Alignment Wee1 and SWE1

DIOPT Version :9

• Sequence 1: NP_001260167.1
• Gene: Wee1 / 33965
• FlyBaseID: FBgn0011737
• Length: 609
• Species: Drosophila melanogaster
• Sequence 2: NP_012348.1
• Gene: SWE1 / 853252
• SGDID: S000003723
• Length: 819
• Species: Saccharomyces cerevisiae
• Alignment Length: 647
• Identity: 141/647 - (21%)
• Similarity: 231/647 - (35%)
• Gaps: 200/647 - (30%)

  Fly     7 EHEMSVTSLDSSVELRSRSP-SPQVFNPRKLRFADDDFDKDTPEGASPQHPLQQRPKLSSGEEQQ 70
            |:|...|.:......::.|| |.:.:|.|  .|..:|...:....:|...  ..:|..|:.....
Yeast   115 ENESVTTPITKRSAEKTNSPISLKQWNQR--WFPKNDARTENTSSSSSYS--VAKPNQSAFTSSG 175

  Fly    71 LDSKIGKEGGDGDVSMSPPCQKVRALRLFSTPATPKTILQ---------KSTTQCSNHLSAAAA- 125
            |.||:..     |.|:.|     ..||:..||.....:::         .|:...|:.||.:..
Yeast   176 LVSKMSM-----DTSLYP-----AKLRIPETPVKKSPLVEGRDHKHVHLSSSKNASSSLSVSPLN 230

  Fly   126 AVNASRRSDDLFRLSERPRSLPLHNRKLPTQDTA---------------NVNPFTPDSLMAHNK- 174
            .|..:...:||. .|:.|.|..|.:..:||.|::               ..|..:|.:.:..|.
Yeast   231 FVEDNNLQEDLL-FSDSPSSKALPSIHVPTIDSSPLSEAKYHAHDRHNNQTNILSPTNSLVTNSS 294

  Fly   175 ------------KRCRTQFGRENLNLNVNAMQK------------------------------YL 197
                        ||.|.....:|..| .|::|:                              |.
Yeast   295 PQTLHSNKFKKIKRARNSVILKNREL-TNSLQQFKDDLYGTDENFPPPIIISSHHSTRKNPQPYQ 358

  Fly   198 LSDACDDDVTEEAGDSMR---------EIHQQA------------------------------PK 223
            .....|:|..||.....|         :.|:::                              .|
Yeast   359 FRGRYDNDTDEEISTPTRRKSIIGATSQTHRESRPLSLSSAIVTNTTSAETHSISSTDSSPLNSK 423

  Fly   224 RLALHDTNI-----SRFKREFMQVNVIGVGEFGVVFQCVNRLDGCIYAIKKSKKPVAGSSFEK-- 281
            |..:....:     |....:|..|:.||.|:|..|:|.........||| |:.||...:|.::
Yeast   424 RRLISSNKLSANPDSHLFEKFTNVHSIGKGQFSTVYQVTFAQTNKKYAI-KAIKPNKYNSLKRIL 487

  Fly   282 ---RALNEVWAHAVL---GKHDNVVRYYSAWAEDDHMLIQNEFCDGGSLHARIQDHCLGEAE--- 337
               :.||||.....:   || :.::.|.|:|...:...|..|.|:.|:|...:|:..:.:.:
Yeast   488 LEIKILNEVTNQITMDQEGK-EYIIDYISSWKFQNSYYIMTELCENGNLDGFLQEQVIAKKKRLE 551

  Fly   338 ---LKIVLMHVIEGLRYIH-SNDLVHMDLKPENIFSTMNPNAHKLVEVQPQQTKDDDGMDSVYEE 398
               :..:::.:...||:|| |..:||:||||.|:..|...|
Yeast   552 DWRIWKIIVELSLALRFIHDSCHIVHLDLKPANVMITFEGN------------------------ 592

  Fly   399 LRHSENLVTYKIGDLG---HVTSVKEPYVEEGDCRYLPKEILHEDYSNLFKADIFSLGITLFEAA 460
                     .|:||.|   |:....:.:..|||..|:..||: .|.:..:||||||||:.:.|.|
Yeast   593 ---------LKLGDFGMATHLPLEDKSFENEGDREYIAPEII-SDCTYDYKADIFSLGLMIVEIA 647

  Fly   461 GGGPLPKNGPEWHNLRDGKVPILPSLSRDFNELIAQMMHPYPDKRPTSQSIFSHPILSAVDS 522
            ....||.||..||.||.|.:       .|...|.:..:|        |:|:||.  ::.||:
Yeast   648 ANVVLPDNGNAWHKLRSGDL-------SDAGRLSSTDIH--------SESLFSD--ITKVDT 692

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wee1	NP_001260167.1	PTKc_Wee1	238..516	CDD:270953	82/295 (28%)
		Pkinase	239..515	CDD:278497	82/293 (28%)
SWE1	NP_012348.1	PTKc_Wee1_fungi	443..791	CDD:270954	84/303 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	113	1.000	Domainoid score	I1344
eggNOG	1	0.900	-	-		E1_KOG0601
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46797
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1671
SonicParanoid	1	1.000	-	-		X1559
TreeFam	0	0.000	Not matched by this tool.
	6	5.840