Protein Alignment Wee1 and GCN2

DIOPT Version :9

• Sequence 1: NP_001260167.1
• Gene: Wee1 / 33965
• FlyBaseID: FBgn0011737
• Length: 609
• Species: Drosophila melanogaster
• Sequence 2: NP_010569.3
• Gene: GCN2 / 851877
• SGDID: S000002691
• Length: 1659
• Species: Saccharomyces cerevisiae
• Alignment Length: 613
• Identity: 129/613 - (21%)
• Similarity: 206/613 - (33%)
• Gaps: 241/613 - (39%)

  Fly   168 SLMAHN--KKRCRT------QFGRENLNLNVNAMQKYLLSDACDDDVTE-EAGDSM-------RE 216
            |.|.:|  |||..|      :|.|.|::..:|...  |:|::.:.:..| ..||::       |.
Yeast   505 SKMLNNDPKKRLGTLELLPMKFLRTNIDSTINRFN--LVSESVNSNSLELTPGDTITVRGNGGRT 567

  Fly   217 IHQQAPKR---------LALHDTNISRFKREFMQVNVIGVGEFGVVFQCVNRLDGCIYAIKKSKK 272
            :.|.:.:|         .:::....||:..:|.::.|:|.|.||.|.:..|.||...|||||.:
Yeast   568 LSQSSIRRRSFNVGSRFSSINPATRSRYASDFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIR- 631

  Fly   273 PVAGSSFEKRA--LNEVWAHAVLGKHDNVVRYYSAWAEDDHM----------------------- 312
                .:.||.:  |:||...|.| .|..|||||:||.|:|.|
Yeast   632 ----HTEEKLSTILSEVMLLASL-NHQYVVRYYAAWLEEDSMDENVFESTDEESDLSESSSDFEE 691

  Fly   313 ----------------------------------------------------------------- 312
                                                                             
Yeast   692 NDLLDQSSIFKNRTNHDLDNSNWDFISGSGYPDIVFENSSRDDENEDLDHDTSSTSSSESQDDTD 756

  Fly   313 ----------------------------LIQNEFCDGGSLHARIQDHCLGEA--ELKIVLMHVIE 347
                                        .||.|:|:..:|:..|....|.:.  |...:...::|
Yeast   757 KESKSIQNVPRRRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRLFRQILE 821

  Fly   348 GLRYIHSNDLVHMDLKPENIFST-----------MNPNAHKLVEVQPQQTKDDDGMDSVYEELRH 401
            .|.||||..::|.||||.|||..           :..|.|:.:::    .|.|
Yeast   822 ALSYIHSQGIIHRDLKPMNIFIDESRNVKIGDFGLAKNVHRSLDI----LKLD------------ 870

  Fly   402 SENLVTYKIGDLGHVTSVKEPYVEEGDCRYLPKEILHEDYSNLFKADIFSLGITLFEAAGGGPLP 466
            |:||.    |...::||.      .|...|:..|:|........|.|::||||..||..    .|
Yeast   871 SQNLP----GSSDNLTSA------IGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMI----YP 921

  Fly   467 -KNGPEWHN----LRDGKVPILPSLSRDFNE--------LIAQMMHPYPDKRPTSQSIFSHPILS 518
             ..|.|..|    ||...:...|    ||::        :|..::...|:|||.::::.:...|.
Yeast   922 FSTGMERVNILKKLRSVSIEFPP----DFDDNKMKVEKKIIRLLIDHDPNKRPGARTLLNSGWLP 982

  Fly   519 AVDSKSKLQLGLELTVEKRKNEILMNKLREAKKQIKLLEQRV------NLLAVTNN-------PD 570
            .                |.::|::...|:.........:|:|      ...::||:       |.
Yeast   983 V----------------KHQDEVIKEALKSLSNPSSPWQQQVRESLFNQSYSLTNDILFDNSVPT 1031

  Fly   571 SLDGQRCLRS-FTRRMRTPFSSHGKFDS 597
            |......||| .|..:...|..||..::
Yeast  1032 STPFANILRSQMTEEVVKIFRKHGGIEN 1059

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wee1	NP_001260167.1	PTKc_Wee1	238..516	CDD:270953	91/421 (22%)
		Pkinase	239..515	CDD:278497	91/419 (22%)
GCN2	NP_010569.3	RWD	18..128	CDD:214735
		PK_eIF2AK_GCN2_rpt1	273..526	CDD:270914	7/20 (35%)
		STKc_EIF2AK4_GCN2_rpt2	593..979	CDD:270948	93/425 (22%)
		HisS	1015..1485	CDD:223202	11/45 (24%)
		HGTP_anticodon2	1387..1657	CDD:403832

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345876
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930