DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wee1 and WEE1

DIOPT Version :9

Sequence 1:	NP_001260167.1	Gene:	Wee1 / 33965	FlyBaseID:	FBgn0011737	Length:	609	Species:	Drosophila melanogaster
Sequence 2:	NP_171796.1	Gene:	WEE1 / 839453	AraportID:	AT1G02970	Length:	500	Species:	Arabidopsis thaliana

Alignment Length:	540	Identity:	144/540 - (26%)
Similarity:	232/540 - (42%)	Gaps:	140/540 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 EGASPQHPLQQRPKLSS-GEEQQLDSKIGKEGGDGDVSMSPPCQKVRALRLFSTPATPKTILQKS 112
            ||...:|.|.|..:||. ..|.:..|.:......|                         :|...
plant    31 EGTLERHSLLQFGQLSKISFENRPSSNVASSAFQG-------------------------LLDSD 70

  Fly   113 TTQCSNHLSAAAAAVNASRR----SDDLFRLSERPRSLPLHNRKLPTQDTANVN----------- 162
            :::..|.|.:|.:..|...:    |.|.|...:           ..|.|..|:.
plant    71 SSELRNQLGSADSDANCGEKDFILSQDFFCTPD-----------YITPDNQNLMSGLDISKDHSP 124

  Fly   163 -PFTPDSLMAHNKKRCRTQFGRENLNLNVNAMQKYLLSDACDDDV-TEEA-GDSMRE-------- 216
             |.:|..|.....||||.:....| :.|.....|:.:.:..:||: |:|. ||.::.
plant   125 CPRSPVKLNTVKSKRCRQESFTGN-HSNSTWSSKHRVDEQENDDIDTDEVMGDKLQANQTERTGY 188

  Fly   217 IHQQA---------------PKRLALHDT-----------------------NISRFKREFMQVN 243
            :.|.|               |..|...:|                       .:||:..:|.::.
plant   189 VSQAAVALRCRAMPPPCLKNPYVLNQSETATDPFGHQRSKCASFLPVSTSGDGLSRYLTDFHEIR 253

  Fly   244 VIGVGEFGVVFQCVNRLDGCIYAIKKSKKPVAGSSFEKRALNEVWAHAVLGKHDNVVRYYSAWAE 308
            .||.|.|..||:.:.|:|||:||:|.|.:.:...|..::|:.||.|.|.||.|:|:|.|||:|.|
plant   254 QIGAGHFSRVFKVLKRMDGCLYAVKHSTRKLYLDSERRKAMMEVQALAALGFHENIVGYYSSWFE 318

  Fly   309 DDHMLIQNEFCDGGSLHARIQDHCL--GEAELKIVLMHVIEGLRYIHSNDLVHMDLKPENIFSTM 371
            ::.:.||.|.|| .||.|..:...|  .|.|:.:::..:.:.|.::|...:.|:|:||:||:
plant   319 NEQLYIQLELCD-HSLSALPKKSSLKVSEREILVIMHQIAKALHFVHEKGIAHLDVKPDNIY--- 379

  Fly   372 NPNAHKLVEVQPQQTKDDDGMDSVYEELRHSENLVTYKIGDLGHVTSV-KEPYVEEGDCRYLPKE 435
                                          .:|.|. |:||.|..|.: |...|||||.||:|:|
plant   380 ------------------------------IKNGVC-KLGDFGCATRLDKSLPVEEGDARYMPQE 413

  Fly   436 ILHEDYSNLFKADIFSLGITLFEAAGGGPLPKNGPEWHNLRDGKVPILPSLSRDFNELIAQMMHP 500
            ||:|||.:|.|.||||||:|::|...|.||.::..:..|:::||:|:||..|....:|:..||..
plant   414 ILNEDYEHLDKVDIFSLGVTVYELIKGSPLTESRNQSLNIKEGKLPLLPGHSLQLQQLLKTMMDR 478

  Fly   501 YPDKRPTSQSIFSHPILSAV 520
            .|.:||:::.:..||:...:
plant   479 DPKRRPSARELLDHPMFDRI 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wee1	NP_001260167.1	PTKc_Wee1	238..516	CDD:270953	99/280 (35%)
Wee1	NP_001260167.1	Pkinase	239..515	CDD:278497	98/278 (35%)
WEE1	NP_171796.1	PKc_Wee1_like	248..493	CDD:270899	98/279 (35%)
WEE1	NP_171796.1	S_TKc	249..495	CDD:214567	100/280 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	177	1.000	Domainoid score	I1075
eggNOG	1	0.900	-	-		E1_KOG0601
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1063695at2759
OrthoFinder	1	1.000	-	-		FOG0003577
OrthoInspector	1	1.000	-	-		oto3516
orthoMCL	1	0.900	-	-		OOG6_104316
Panther	1	1.100	-	-	LDO	PTHR11042
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1559
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.780