DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wee1 and eif2ak2

DIOPT Version :9

Sequence 1:	NP_001260167.1	Gene:	Wee1 / 33965	FlyBaseID:	FBgn0011737	Length:	609	Species:	Drosophila melanogaster
Sequence 2:	NP_001072537.1	Gene:	eif2ak2 / 779992	XenbaseID:	XB-GENE-1001011	Length:	552	Species:	Xenopus tropicalis

Alignment Length:	334	Identity:	89/334 - (26%)
Similarity:	142/334 - (42%)	Gaps:	95/334 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 HQQAPKRLALHDTNISRFKREFMQVNVIGVGEFGVVFQCVNRLDGCIYAIKKSKKPVAGSSFEKR 282
            :|:...:..|.:|    |.|.|.:::.:|.|.||.|.:...:|....||||:.|       ...:
Frog   259 NQEKGAQCTLDET----FLRNFTEISRLGSGGFGTVLKAKCKLANKYYAIKRVK-------LYDK 312

  Fly   283 ALNEVWAHAVLGKHDNVVRYYSAW---------------------AEDDHMLIQNEFCDGGSLHA 326
            .:.||.|.|.| .|.|:|||..:|                     ::||::.||.|:|:.|:|.:
Frog   313 CVKEVEALAHL-DHPNIVRYNHSWTGEDCCSESTYSNSDFSSSPGSKDDYLFIQMEWCEKGTLKS 376

  Fly   327 RIQDHCLGEAELK--IVLMHVIEGLRYIHSNDLVHMDLKPENIFSTMNPNAHKLVEVQPQQTKDD 389
            .|: |.....:.|  ::...:|||:|||||..|:|.||||.|||..
Frog   377 WIK-HMNKVEKFKSLVIFRQIIEGVRYIHSKGLIHRDLKPANIFFA------------------- 421

  Fly   390 DGMDSVYEELRHSENLVTYKIGDLGHVTSVK--------EPYVEEGDCRYLPKEILHEDYSNLFK 446
                   |:::       .||||.|.||.:.        |.....|...|:..|...|.|.:  :
Frog   422 -------EDMK-------IKIGDFGLVTQMTGEADRQALERTKGRGTKPYMAPEQYEETYES--E 470

  Fly   447 ADIFSLGITL------FEAAGGGPLPKNGPEWHNLRDGKVPILPSLSRDF---NELIAQMMHPYP 502
            .|||.||:.|      |:.     :.:...||..||:|::|  |:..:.:   ..:|.:::....
Frog   471 VDIFPLGLILVELFYIFKT-----VHEKQEEWKKLRNGELP--PAFVQQYPTEESIIKKILSRDR 528

  Fly   503 DKRPTSQSI 511
            .||||:..:
Frog   529 KKRPTAAQL 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wee1	NP_001260167.1	PTKc_Wee1	238..516	CDD:270953	84/314 (27%)
Wee1	NP_001260167.1	Pkinase	239..515	CDD:278497	84/313 (27%)
eif2ak2	NP_001072537.1	DSRM_RNAse_III_family	5..71	CDD:380682
		DSRM_EIF2AK2-like	118..183	CDD:380704
		PKc_like	269..541	CDD:389743	87/324 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910