Protein Alignment Wee1 and eif2ak1

DIOPT Version :9

• Sequence 1: NP_001260167.1
• Gene: Wee1 / 33965
• FlyBaseID: FBgn0011737
• Length: 609
• Species: Drosophila melanogaster
• Sequence 2: XP_021335808.1
• Gene: eif2ak1 / 565338
• ZFINID: ZDB-GENE-061013-268
• Length: 667
• Species: Danio rerio
• Alignment Length: 619
• Identity: 126/619 - (20%)
• Similarity: 199/619 - (32%)
• Gaps: 265/619 - (42%)

  Fly   147 PLHNR---KLPTQDTANVNPFTPDSLMAHNKKRCRTQFGR---ENLNLNVNAM----QKYLLSDA 201
            |..:|   |:..|..|.:|..:|.:: :......|.|..|   |.|:...:::    .|||.::
Zfish   109 PTRSRMLFKVIGQRLAAMNLLSPLAI-SDEFSTVRLQHNRAFTELLHATSSSLFPQEHKYLSTE- 171

  Fly   202 CDDDVTEEAGDSMREIHQQAPKRLALHDTNISRFKREFMQVNVIGVGEFGVVFQCVNRLDGCIYA 266
                     |.|.|       .:..|.....||:..||.::..:|.|.:|.||:..|:|||..||
Zfish   172 ---------GQSKR-------TKDGLFQAQTSRYLSEFEEIATLGKGSYGKVFRVTNKLDGQEYA 220

  Fly   267 IKK--SKKPVAGSSFEKRALNEVWAHAVLGKHDNVVRYYSAW----------------------- 306
            :||  .||.......  :.|.||...:.| :|.|:|.|::||
Zfish   221 VKKILIKKVTRDDCM--KVLREVKVLSSL-QHPNIVGYHTAWMEHVQPAVTDSNSLVSQTFPALD 282

  Fly   307 ----------------------------------------------------------------- 306
                                                                             
Zfish   283 RPSEPNGCTPEHTNSSNGSFIVFEHSERAEVKENQVALESISVNPSTSKVDMAQSVCPKNVRKPQ 347

  Fly   307 ----------------------------AEDD-------------------------------HM 312
                                        :|||                               |:
Zfish   348 NFVPCVFLGKPRSTLNKCPAANWDSSTLSEDDLSQNRLELNKHSYIDMDTPEWSEKQENKVQFHL 412

  Fly   313 L--IQNEFCDGGSLHARIQDH-------------------CLGEAELKIVLMHVIEGLRYIHSND 356
            :  ||.:.|: .||...||:.                   |  |..||| |..::||:.||||..
Zfish   413 MLYIQMQLCE-RSLKDWIQERNSRTTEGLLMSGDPCDSVDC--EQALKI-LKKILEGVEYIHSCG 473

  Fly   357 LVHMDLKPENIFSTMNPNAHKLVEVQPQQTKDDDG-------MDSVYEELRHSENLVTYKIG--- 411
            ::|.||||.|||...|....|:         .|.|       ||. :|:|..|.     :.|
Zfish   474 IMHRDLKPRNIFLLGNECHVKI---------GDFGLACQNIIMDE-HEKLPSSS-----QAGVNP 523

  Fly   412 DLGHVTSVKEPYVEEGDCRY-LPKEILHEDYSNLFKADIFSLGITLFEAAGGGPLPKNGPEWH-- 473
            |..|.:.|       |...| .|:::....|.:  |:|::|:|:..||..  .|........|
Zfish   524 DATHTSGV-------GTFVYAAPEQLEGSRYDS--KSDMYSIGVIAFELF--QPFGTEMERVHTL 577

  Fly   474 -NLRDGKVPILPSLSRDFNEL---IAQMMHPYPDKRPTSQSIFSHPILSAVDSKSKLQLGLELTV 534
             .||.||:|  .:||.::..|   |..:....|..||::..:....:.|..|          :.:
Zfish   578 GELRQGKIP--NTLSTNWPILAKYIKLLTSSDPSMRPSAPQLLQSDLFSTND----------MVI 630

  Fly   535 EKRKNEILMNKLREAKKQIKLLEQRVNLLAVTNN 568
            ..     |..|:.|.:::|..|.:|::.|.::.|
Zfish   631 HS-----LKRKIDEQEEEIVQLRRRISELQISQN 659

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wee1	NP_001260167.1	PTKc_Wee1	238..516	CDD:270953	95/464 (20%)
		Pkinase	239..515	CDD:278497	94/462 (20%)
eif2ak1	XP_021335808.1	STKc_EIF2AK1_HRI	186..620	CDD:270951	97/468 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594253
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930