Protein Alignment Wee1 and EIF2AK2

DIOPT Version :9

• Sequence 1: NP_001260167.1
• Gene: Wee1 / 33965
• FlyBaseID: FBgn0011737
• Length: 609
• Species: Drosophila melanogaster
• Sequence 2: NP_001129123.1
• Gene: EIF2AK2 / 5610
• HGNCID: 9437
• Length: 551
• Species: Homo sapiens
• Alignment Length: 547
• Identity: 135/547 - (24%)
• Similarity: 212/547 - (38%)
• Gaps: 170/547 - (31%)

  Fly    57 LQQRPKLSSGEEQQLDSKIGKEG-------GDGDVSMSPPCQKVRALRLFSTPATPKTILQKSTT 114
            :.|:.:|:...||......|.||       |..:.|:.....|..|.:|.:..|..: ||.:.|:
Human   108 IAQKKRLTVNYEQCASGVHGPEGFHYKCKMGQKEYSIGTGSTKQEAKQLAAKLAYLQ-ILSEETS 171

  Fly   115 QCSNHLSAAAAAVNASRRSDDLFRLSERPRSLPLHNRKLPTQDTANVNPFTPDSLMAHNKKRCRT 179
            ..|::||:.:.|.....:|:.|...:....|   .:....:.||:.:|. ..|||
Human   172 VKSDYLSSGSFATTCESQSNSLVTSTLASES---SSEGDFSADTSEINS-NSDSL---------- 222

  Fly   180 QFGRENLNLNVNAMQKYLLSDACDDDVTEEAGDSMREIHQQAPKRLALHD------TNISRFKRE 238
                .:.:|.:|.::                 ::.|:..:....|..|.|      |...||..:
Human   223 ----NSSSLLMNGLR-----------------NNQRKAKRSLAPRFDLPDMKETKYTVDKRFGMD 266

  Fly   239 FMQVNVIGVGEFGVVFQCVNRLDGCIYAIKKSKKPVAGSSFEKRALNEVWAHAVLGKHDNVVRYY 303
            |.::.:||.|.||.||:..:|:||..|.||:.|..      .::|..||.|.|.| .|.|:|.|.
Human   267 FKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYN------NEKAEREVKALAKL-DHVNIVHYN 324

  Fly   304 SAW--------AEDDH---------------------MLIQNEFCDGGSLHARIQDHCLGEAELK 339
            ..|        ..||.                     :.||.||||.|:|...|:.. .||...|
Human   325 GCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKR-RGEKLDK 388

  Fly   340 IVLMHVIE----GLRYIHSNDLVHMDLKPENIFSTMNPNAHKLVEVQPQQTKDDDGMDSVYEELR 400
            ::.:.:.|    |:.||||..|:|.||||.|||         ||:     ||.
Human   389 VLALELFEQITKGVDYIHSKKLIHRDLKPSNIF---------LVD-----TKQ------------ 427

  Fly   401 HSENLVTYKIGDLGHVTSVK---EPYVEEGDCRYL-PKEILHEDYSNLFKADIFSLGI------- 454
                   .||||.|.|||:|   :....:|..||: |::|..:||..  :.|:::||:
Human   428 -------VKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGK--EVDLYALGLILAELLH 483

  Fly   455 ---TLFEAAGGGPLPKNGPEWHNLRDGKVPILPSLSRDFNELIAQMMHPYPDKRPTSQSIFSHPI 516
               |.||.:         ..:.:||||.:..:  ..:....|:.:::...|:.||.:..|..
Human   484 VCDTAFETS---------KFFTDLRDGIISDI--FDKKEKTLLQKLLSKKPEDRPNTSEILR--- 534

  Fly   517 LSAVDSKSKLQLGLELTVEKR---KNE 540
                          .|||.|:   |||
Human   535 --------------TLTVWKKSPEKNE 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wee1	NP_001260167.1	PTKc_Wee1	238..516	CDD:270953	90/324 (28%)
		Pkinase	239..515	CDD:278497	90/322 (28%)
EIF2AK2	NP_001129123.1	(Microbial infection) Interaction with HCV NS5A. /evidence=ECO:0000269|PubMed:17267064	2..180		19/72 (26%)
		DSRM	14..>59	CDD:214634
		DSRM	101..166	CDD:214634	13/58 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	202..222		5/23 (22%)
		STKc_EIF2AK2_PKR	260..536	CDD:270949	92/346 (27%)
		Interaction with TRAF5. /evidence=ECO:0000269|PubMed:15121867	266..551		97/353 (27%)
		2 X 13 AA approximate repeats	331..357		2/25 (8%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158338
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840