Protein Alignment Wee1 and eif2ak3

DIOPT Version :10

• Sequence 1: NP_477035.1
• Gene: Wee1 / 33965
• FlyBaseID: FBgn0011737
• Length: 609
• Species: Drosophila melanogaster
• Sequence 2: XP_005156642.3
• Gene: eif2ak3 / 559564
• ZFINID: ZDB-GENE-050414-2
• Length: 1099
• Species: Danio rerio
• Alignment Length: 796
• Identity: 145/796 - (18%)
• Similarity: 229/796 - (28%)
• Gaps: 374/796 - (46%)

  Fly    13 TSLDSSVELRSRSPSPQVFNPRKLRFADDDFDKDTPEGASP----------QHPLQQRPKLSSGE 67
            ||.:|..|..::.              |||..::. .||:.          |..||...::|
Zfish   375 TSYNSQTETETQE--------------DDDIMEEA-RGATESSVYLGMFQGQLYLQSSVRIS--- 421

  Fly    68 EQQLDSK---IGKEGGDGDVSMSPPCQKVRALRLFSTPATPKTILQKSTTQCSN-----HLSAAA 124
             ::..||   :...|||.|: |.||..|.:.| :.|...||..:..:...:|.|     |...:.
Zfish   422 -EKFPSKSKALNGWGGDTDM-MPPPTVKWKPL-IHSPSRTPVLVGSEEFDKCLNNDKFSHEEYSN 483

  Fly   125 AAVNASRRSDD---LFRLSERPRSLPLHNRKLPT-----------------QDTANVNP------ 163
            .|::..:...|   .|..|.|.|     ||:..|                 :|...:.|
Zfish   484 GALSILQYPYDNGYYFPYSPRYR-----NRRDETAVSVLLKKDGEGSQVRRKDPVLLLPWWKEIL 543

  Fly   164 -----------------FTPDSLMAHNKKRCRTQFGRENLNLNVNAMQKYLLSDACDDDVTEEAG 211
                             |.|.:..:..:|...||...:.         |:      :.||||
Zfish   544 GTIFFCIAATTYIVRKFFHPPTTYSRQRKESETQCQTDT---------KF------EADVTE--- 590

  Fly   212 DSMREIHQQAPKRLALHDTN----ISRFKREFMQVNVIGVGEFGVVFQCVNRLDGCIYAIKKSKK 272
                      ||.:.:.|..    :||:..:|..|..:|.|.|||||:..|::|.|.||||:.:.
Zfish   591 ----------PKEVVVTDMRPCEYVSRYLTDFEPVQCLGRGGFGVVFEARNKVDDCNYAIKRIRL 645

  Fly   273 PVAGSSFEKRALNEVWAHAVLGKHDNVVRYYSAWAED---------------------------D 310
            |....:.|| .:.||.|.|.| :|..::||::||.|.                           :
Zfish   646 PNRELAREK-VMREVKALAKL-EHPGIIRYFNAWQESPPQGWQEDMDKRWLKDASTADWLLSSPE 708

  Fly   311 HM--------------------------------------------------------------- 312
            ||
Zfish   709 HMEAFSVKVPVATPSPVDSSCMCAAGGDTSVCVGDQVCVEGLGPDSMMSERDSQADPDAIMEVSD 773

  Fly   313 ----------------------------------------------------------------- 312
                                                                             
Zfish   774 SPHSFELCPPRTVAHGDCTSSSFDIVFEDSGCEHQDNDSDLSGSTPVPPVCLSQSGSKPQRSTST 838

  Fly   313 ----------------------------------LIQNEFCDGGSLHARIQDHCLGE----AELK 339
                                              .||.:.|...:|...:...||.|    .:..
Zfish   839 GPPISLPSRPTTLSLAPSTPCPVVRPLLTPKVYLYIQMQLCRKENLKDWMAQRCLPELREHTQCL 903

  Fly   340 IVLMHVIEGLRYIHSNDLVHMDLKPENIFSTMNPNAHKLVEVQPQQTKDDDGMDSVYEELRHSEN 404
            .:.:.:.|.:.::||..|:|.||||.|||.||                 ||
Zfish   904 DIFLQIAEAVDFLHSKGLMHRDLKPSNIFFTM-----------------DD-------------- 937

  Fly   405 LVTYKIGDLGHVTSVKEPYVEE------------------GDCRYL-PKEILHEDYSNLFKADIF 450
              ..|:||.|.||::.:...:|                  |...|: |:::....||:  |.||:
Zfish   938 --VVKVGDFGLVTAMDQEEDDEELSTLTPMPIYARHTGQVGTKLYMSPEQLSGNSYSH--KVDIY 998

  Fly   451 SLGITLFEAAGGGPLPKNGPEWHNLRDGKVPILPSLSRDFNELIAQ----MMHPYPDKRPTSQSI 511
            |||:.|||..  .|..........|.:.:....|:.....|.|.||    |:...|.:||.:..|
Zfish   999 SLGLILFELL--CPFRTQMERVRTLTEVRALQFPAAFCKANILEAQMVRCMLSRVPAERPEASEI 1061

  Fly   512 FSHPILSAVDSKSKLQ 527
            ...|:...::...:::
Zfish  1062 TEAPLFQELEVPCRIR 1077

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wee1	NP_477035.1	PTKc_Wee1	238..516	CDD:270953	88/493 (18%)
eif2ak3	XP_005156642.3	None