DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wee1 and Wee2

DIOPT Version :9

Sequence 1:	NP_001260167.1	Gene:	Wee1 / 33965	FlyBaseID:	FBgn0011737	Length:	609	Species:	Drosophila melanogaster
Sequence 2:	XP_038964568.1	Gene:	Wee2 / 502750	RGDID:	1587197	Length:	557	Species:	Rattus norvegicus

Alignment Length:	581	Identity:	202/581 - (34%)
Similarity:	296/581 - (50%)	Gaps:	127/581 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SEHEMSVTSLDSSVELRSRSPSPQ----------VFNPRKLRFADDDFDKDTPEGASPQHPLQQR 60
            :|:|..:|:.|..   |::|..|:          |.:||...:...:.||.:|..|       .|
  Rat    23 TENEGQMTAQDIG---RAQSQKPRRDQSEELEGPVSSPRDELYTSLNRDKQSPGPA-------LR 77

  Fly    61 PKLSSGEEQQLDSKIGKEGGDGDVSMSPPCQKVRALRLFSTP---ATPKTI--------LQKSTT 114
            ..:|                  |.|..|....:.:......|   :|||.:        |:|...
  Rat    78 TSVS------------------DFSTCPDTPVLNSKSKLPVPTNFSTPKNLLGQPEISSLEKLYV 124

  Fly   115 QCSNHLSAAAAAVNASRRSDDLFRLSERPRSLPLHNRKLPTQDTANVNPFTPDS-----LMAHNK 174
            :.|.||.....:            |.:...||.|          .|:|||||::     |.:..|
  Rat   125 RSSKHLRLTPTS------------LMDEKTSLSL----------VNINPFTPETYRKLFLQSKGK 167

  Fly   175 KRCRTQFGRENLNLNVNAMQKYLLSDACDDDVTEEAGDSMREIHQQAPKRLALHDTNI-SRFKRE 238
            ::.|                          |..||.|:...:......||..|.:||: ||:::|
  Rat   168 RKTR--------------------------DYLEETGEGESKAMWLPAKRSVLQETNMASRYEKE 206

  Fly   239 FMQVNVIGVGEFGVVFQCVNRLDGCIYAIKKSKKPVAGSSFEKRALNEVWAHAVLGKHDNVVRYY 303
            |.:|..|||||||.|::|:.||||||||||:|.|..:|.| ....|:||:||||||.|.:|||||
  Rat   207 FFEVEKIGVGEFGTVYKCIKRLDGCIYAIKRSAKSFSGLS-NDLDLHEVYAHAVLGHHPHVVRYY 270

  Fly   304 SAWAEDDHMLIQNEFCDGGSLHARI-----QDHCLGEAELKIVLMHVIEGLRYIHSNDLVHMDLK 363
            |:|.||:|::||||:|:||||.|.|     .|:...|.:||.:|:.:..||:|||::.:||:|:|
  Rat   271 SSWVEDNHVVIQNEYCNGGSLQAAISENADSDNHFQEPKLKDILLQISLGLKYIHNSGMVHLDIK 335

  Fly   364 PENIFSTMNPNAHKL---VEVQPQQTKDDDGMDSVYEELRHSENLVTYKIGDLGHVTSVKEPYVE 425
            |.|||.     .||:   ..|.|::|:.:       .:...:.| |.||||||||.||:.:|.||
  Rat   336 PSNIFI-----CHKIQSDCPVGPEETESE-------ADWFLNAN-VMYKIGDLGHATSISKPKVE 387

  Fly   426 EGDCRYLPKEILHEDYSNLFKADIFSLGITLFEAAGGGPLPKNGPEWHNLRDGKVP-ILPSLSRD 489
            |||.|:|..|||.|:|.:|.|||||:||:|:..|||..|||.||.:||::|.|..| |...||.|
  Rat   388 EGDTRFLANEILQENYQHLPKADIFALGLTIAMAAGAEPLPINGDKWHHIRKGNFPEISQELSDD 452

  Fly   490 FNELIAQMMHPYPDKRPTSQSIFSHPILSAVDSKSKLQLGLELTVEKRKNEILMNKLREAK 550
            |..|:..|:||.|::||::.::....||.....|:: :|..:|.:||.|...|..:|::|:
  Rat   453 FYGLLKNMIHPVPEERPSAATLARSRILWPFLEKTE-ELQKQLNLEKSKTATLKRELKKAQ 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wee1	NP_001260167.1	PTKc_Wee1	238..516	CDD:270953	139/286 (49%)
Wee1	NP_001260167.1	Pkinase	239..515	CDD:278497	138/284 (49%)
Wee2	XP_038964568.1	PKc_like	206..476	CDD:419665	139/283 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352319
Domainoid	1	1.000	287	1.000	Domainoid score	I1520
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1063695at2759
OrthoFinder	1	1.000	-	-		FOG0003577
OrthoInspector	1	1.000	-	-		otm46321
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11042
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1559
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.950