DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wee1 and wee2

DIOPT Version :9

Sequence 1:	NP_001260167.1	Gene:	Wee1 / 33965	FlyBaseID:	FBgn0011737	Length:	609	Species:	Drosophila melanogaster
Sequence 2:	NP_001038367.1	Gene:	wee2 / 327471	ZFINID:	ZDB-GENE-030131-5682	Length:	532	Species:	Danio rerio

Alignment Length:	567	Identity:	220/567 - (38%)
Similarity:	310/567 - (54%)	Gaps:	117/567 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 ADDDFDKDTPEGASPQHPLQQRPKLSSGEEQQLDSKIGKEGGDGDVSMSPPCQKV-----RALRL 98
            :|:.||:.|.:....:.|. :.|::.....:.:           .||.|.|...:     :.|||
Zfish    27 SDNSFDEWTHKSVPLRSPC-RTPRIQRHRNRSI-----------TVSPSVPTSPIPYAAWKKLRL 79

  Fly    99 FSTPATPKTILQKSTTQCSNHLSAAAAAVNASRRSDDLFRLSERPRSLPLHNRKLPTQDTANVNP 163
            ..:|:|||::|.|||..||:         :.:.||....|||.....:|          :.|:||
Zfish    80 CDSPSTPKSLLSKSTMPCSS---------SKTCRSQRFLRLSTAFERVP----------SVNINP 125

  Fly   164 FTPDSL---MAHNKKRCRTQFGRENLNLNVNAMQKYLLSDACDDDVTEEAGDSMREIHQQA---- 221
            ||||::   ..|.|::                      |...|||  |:.|...:||...:
Zfish   126 FTPDTVRRNSEHYKRK----------------------SQRSDDD--EDYGPRSKEIQNSSEDES 166

  Fly   222 ----PKRLALHDTNISRFKREFMQVNVIGVGEFGVVFQCVNRLDGCIYAIKKSKKPVAGSSFEKR 282
                .||.|:....:||::.||:::..|||||||.|::||.|||||:||||:|::|:|||:.|:.
Zfish   167 FFLPSKRPAVSARMLSRYESEFLELACIGVGEFGSVYRCVKRLDGCMYAIKRSRRPIAGSANEQL 231

  Fly   283 ALNEVWAHAVLGKHDNVVRYYSAWAEDDHMLIQNEFCDGGSLH-----ARIQDHCLGEAELKIVL 342
            ||.||:||||||.|.:||||||||||||||:||||:|||||||     .|.|.......||:.:|
Zfish   232 ALKEVYAHAVLGHHPHVVRYYSAWAEDDHMIIQNEYCDGGSLHDAITEKREQGEFFSVPELRDLL 296

  Fly   343 MHVIEGLRYIHSNDLVHMDLKPENIF----STMNPNAHKLVEVQPQQTKDDDGMDSVYEELRHSE 403
            :.|..||:|||::.|||:|:||.|||    ||::...              :| ||..|:..||.
Zfish   297 LQVSMGLKYIHNSGLVHLDIKPSNIFICRRSTLSAGG--------------EG-DSEEEDESHSS 346

  Fly   404 NLVTYKIGDLGHVTSVKEPYVEEGDCRYLPKEILHEDYSNLFKADIFSLGITLFEAAGGGPLPKN 468
            .:| |||||||||||:..|.|||||.|:|..|:|.|||::|.|||||:||:|:..|||..|||:|
Zfish   347 GVV-YKIGDLGHVTSISSPQVEEGDSRFLAYEVLREDYTHLPKADIFALGLTVLLAAGASPLPQN 410

  Fly   469 GPEWHNLRDGKVPILP-SLSRDFNELIAQMMHPYPDKRPTSQSIFSHPILSAVDSKSKL--QLGL 530
            |.:||.||.|::|.|| .|...|.:|:..::.|.|..||::.::..|.:| ..:...||  ||..
Zfish   411 GDDWHRLRQGELPNLPHELPALFKDLLKSLLDPDPTARPSATALCRHDVL-CKERAGKLATQLRK 474

  Fly   531 ELTVEKRKNEILMNKLREAKKQIKLLEQRVNLLAVTN-----NPDSL 572
            ||.|||.:..:|..:|:||:            ||.|:     .|.||
Zfish   475 ELNVEKFRTAMLERELKEAR------------LAATSPQQSCQPGSL 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wee1	NP_001260167.1	PTKc_Wee1	238..516	CDD:270953	149/287 (52%)
Wee1	NP_001260167.1	Pkinase	239..515	CDD:278497	147/285 (52%)
wee2	NP_001038367.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	123..166		16/66 (24%)
		PTKc_Wee1b	187..459	CDD:271041	149/287 (52%)
		Pkinase	194..460	CDD:278497	147/281 (52%)
		SPX	433..>516	CDD:271919	27/90 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594251
Domainoid	1	1.000	293	1.000	Domainoid score	I1484
eggNOG	1	0.900	-	-		E1_KOG0601
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	369	1.000	Inparanoid score	I2094
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1063695at2759
OrthoFinder	1	1.000	-	-		FOG0003577
OrthoInspector	1	1.000	-	-		otm25820
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11042
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1671
SonicParanoid	1	1.000	-	-		X1559
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.890