DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wee1 and wee1

DIOPT Version :9

Sequence 1:	NP_001260167.1	Gene:	Wee1 / 33965	FlyBaseID:	FBgn0011737	Length:	609	Species:	Drosophila melanogaster
Sequence 2:	NP_001296364.1	Gene:	wee1 / 327060	ZFINID:	ZDB-GENE-030131-5268	Length:	612	Species:	Danio rerio

Alignment Length:	586	Identity:	238/586 - (40%)
Similarity:	319/586 - (54%)	Gaps:	85/586 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 EMSVTSLDSSVEL-RSRSPSPQ-VFNPRKL-RFADDDFDKDTPEGASPQH------------PLQ 58
            |...|.|||.|.| ||....|: :.|...| |..|||...|.....||..            |.:
Zfish    43 ESGFTELDSPVPLRRSLEKRPEDLGNSSPLSRNRDDDESWDEEGFGSPSRVKPAFYMKSSPSPRK 107

  Fly    59 QRPKLSSGEEQQL--DSKIGKEGGDGDVSMSPPCQKVRALRLFSTPATPKTILQKSTTQCS---- 117
            ..|...|..|:..  |...|......|...:||.:..|.||||.||.|||::|.::.|..|
Zfish   108 SPPAYDSSPERSYIHDDMEGSSSPIPDCPDTPPHKTFRKLRLFDTPHTPKSLLSRARTMGSTSRR 172

  Fly   118 -----NHLSAAAAAVNASRRSDDLFRLSERPRSLPLHNRKLPTQDTANVNPFTPDSLMAHNKKRC 177
                 |..|.:.|.::..|        ::.||              .|:|||||||::..:....
Zfish   173 VALFTNVDSTSKACLDGKR--------NQTPR--------------VNINPFTPDSILVQSSTLQ 215

  Fly   178 RTQFGRENLNLNVNAMQKYLLSDACDDDVTEEAGDSMREIHQQAP-KRLALHDTN-ISRFKREFM 240
            |....|.:.|            |:|.:|:  :|.|:..|.....| ||:.:.:.| :||:..||.
Zfish   216 RNNRKRSHWN------------DSCGEDM--DASDAEIEDELIPPSKRITMMENNMMSRYASEFH 266

  Fly   241 QVNVIGVGEFGVVFQCVNRLDGCIYAIKKSKKPVAGSSFEKRALNEVWAHAVLGKHDNVVRYYSA 305
            ::..||.|:||.||:||.||||||||||:||||:|||..|:.||.||:||||||:|.:|||||||
Zfish   267 ELEKIGSGQFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHPHVVRYYSA 331

  Fly   306 WAEDDHMLIQNEFCDGGSLHARIQD-----HCLGEAELKIVLMHVIEGLRYIHSNDLVHMDLKPE 365
            ||||||||||||:|:||:|...|.:     |.|.|.|||.:|:.|..||:||||..|||||:||.
Zfish   332 WAEDDHMLIQNEYCNGGTLSDVIAENNRRMHFLSELELKDLLLQVSRGLKYIHSTALVHMDIKPS 396

  Fly   366 NIFSTMNPNAHKLVEVQPQQTKDDDGMDSVYEELRHSENLVTYKIGDLGHVTSVKEPYVEEGDCR 430
            |||.:..|.|    .|:..:.::|....:           |.||||||||||:|..|.|||||.|
Zfish   397 NIFISRKPAA----SVEEFEDEEDGPTTN-----------VVYKIGDLGHVTTVTNPQVEEGDSR 446

  Fly   431 YLPKEILHEDYSNLFKADIFSLGITLFEAAGGGPLPKNGPEWHNLRDGKVPILPS-LSRDFNELI 494
            :|..|:|.||||||.|||||:|.:|:..|:|..|||.||.:||.:|.|.:|.:|. ||::|..|:
Zfish   447 FLANEVLQEDYSNLKKADIFALALTVVSASGAEPLPTNGDKWHKIRQGILPHIPQVLSQEFLSLL 511

  Fly   495 AQMMHPYPDKRPTSQSIFSHPILSAVDSKSKLQLGLELTVEKRKNEILMNKLREAKKQIKLLEQR 559
            ..|:||.|.:||::..:..||:|......|..||.:||..||.||.:|..:|::|:......|:|
Zfish   512 KLMIHPDPTRRPSTSELVRHPVLLTASRMSADQLRVELNAEKFKNALLQKELKKAQMAKAAAEER 576

  Fly   560 V 560
            |
Zfish   577 V 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wee1	NP_001260167.1	PTKc_Wee1	238..516	CDD:270953	151/283 (53%)
Wee1	NP_001260167.1	Pkinase	239..515	CDD:278497	149/281 (53%)
wee1	NP_001296364.1	PKc_like	259..533	CDD:304357	153/288 (53%)
wee1	NP_001296364.1	Pkinase	265..534	CDD:278497	151/283 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594255
Domainoid	1	1.000	293	1.000	Domainoid score	I1484
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31152
Inparanoid	1	1.050	369	1.000	Inparanoid score	I2094
OMA	1	1.010	-	-		QHG46922
OrthoDB	1	1.010	-	-		D1063695at2759
OrthoFinder	1	1.000	-	-		FOG0003577
OrthoInspector	1	1.000	-	-		otm25820
orthoMCL	1	0.900	-	-		OOG6_104316
Panther	1	1.100	-	-	O	PTHR11042
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1671
SonicParanoid	1	1.000	-	-		X1559
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.900