Protein Alignment Wee1 and Wee1

DIOPT Version :9

• Sequence 1: NP_001260167.1
• Gene: Wee1 / 33965
• FlyBaseID: FBgn0011737
• Length: 609
• Species: Drosophila melanogaster
• Sequence 2: NP_001012760.1
• Gene: Wee1 / 308937
• RGDID: 1307895
• Length: 646
• Species: Rattus norvegicus
• Alignment Length: 655
• Identity: 251/655 - (38%)
• Similarity: 344/655 - (52%)
• Gaps: 131/655 - (20%)

  Fly     5 QSEHEMS--VTSLDSSVELRSRSPSPQVFNPRKLRFADDDFDKDTPEGASPQHP--LQQRPKLSS 65
            :.|.|.|  .|..||:.: ...||.|...:|.:   |:.:..:.:| ||.|..|  |::...|..
  Rat    38 EEEEEGSGHSTGEDSAFQ-EPDSPLPSARSPAE---AEAERRRRSP-GAEPSSPGELEEDLLLRG 97

  Fly    66 G----------------EEQQLDSK-----------IGKE------GGDGDVS------------ 85
            |                ||:...|.           :|..      ||.||.|
  Rat    98 GGGGAQAAGGGAEGDSWEEEGFGSSSPVKSPTTAYFLGSSFSPVRCGGPGDASPRGCGVPRAMDD 162

  Fly    86 ---------MSPPCQKVRALRLFSTPATPKTILQKSTTQCSNHLSAAAAAVNASR---RSDDLFR 138
                     .:||.:..|.||||.||.|||::|.|            |..:::|.   |...||.
  Rat   163 PCSPQPDYPSTPPHKTFRKLRLFDTPHTPKSLLSK------------ARVIDSSSVKLRGSSLFM 215

  Fly   139 LSERPRSLPLHNRKLPTQDTANVNPFTPDSLMAHNKKRCRTQFGRENLNLNVNAMQKYLLSDACD 203
            .:|:........|:.|   ..|:||||||.:|.|:..:||   ||:....|          |:.:
  Rat   216 DTEKSGKREFDTRQTP---QVNINPFTPDPVMLHSSGQCR---GRKRAYFN----------DSSE 264

  Fly   204 DDVTEEAGDSMREIHQQAPKRLALHDTNI-SRFKREFMQVNVIGVGEFGVVFQCVNRLDGCIYAI 267
            |   .||.|...|...:..||:.:.::|: ||:..||.::..||.||||.||:||.|||||||||
  Rat   265 D---MEASDYEFEDETRPAKRITITESNMKSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAI 326

  Fly   268 KKSKKPVAGSSFEKRALNEVWAHAVLGKHDNVVRYYSAWAEDDHMLIQNEFCDGGSLHARIQDH- 331
            |:||||:|||..|:.||.||:||||||:|.:||||:||||||||||||||:|:||||...:.::
  Rat   327 KRSKKPLAGSVDEQNALREVYAHAVLGQHPHVVRYFSAWAEDDHMLIQNEYCNGGSLADAVSENY 391

  Fly   332 ----CLGEAELKIVLMHVIEGLRYIHSNDLVHMDLKPENIF--STMNPNAHKLVEVQPQQTKDDD 390
                ...|||||.:|:.|..|||||||..|||||:||.|||  .|..|||     |..:..:||
  Rat   392 RVMSYFTEAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNA-----VSEEGDEDD- 450

  Fly   391 GMDSVYEELRHSENLVTYKIGDLGHVTSVKEPYVEEGDCRYLPKEILHEDYSNLFKADIFSLGIT 455
                      ...|.|.:|||||||||.:..|.|||||.|:|..|:|.|:||:|.|||||:|.:|
  Rat   451 ----------WISNKVMFKIGDLGHVTRISSPQVEEGDSRFLANEVLQENYSHLPKADIFALALT 505

  Fly   456 LFEAAGGGPLPKNGPEWHNLRDGKVPILPS-LSRDFNELIAQMMHPYPDKRPTSQSIFSHPILSA 519
            :..|||..|||:||.:||.:|.|::|.:|. ||::..||:..|:||.|::||::..:..|.:|.:
  Rat   506 VVCAAGAEPLPRNGDQWHEIRQGRLPRIPQVLSQELTELLKVMIHPDPERRPSAMVLVKHSVLLS 570

  Fly   520 VDSKSKLQLGLELTVEKRKNEILMNKLREAKKQIK-------LLEQRVNLLAVT--NNPDSLDGQ 575
            ...||..||.:||..||.||.:|..:|::|:...|       ||..|:...:.|  |....|.|:
  Rat   571 ASRKSAEQLRIELNAEKFKNSLLQKELKKAQMAAKVAAEERALLTDRMATRSTTQSNRTSRLIGK 635

  Fly   576 RCLRS 580
            :..||
  Rat   636 KMNRS 640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wee1	NP_001260167.1	PTKc_Wee1	238..516	CDD:270953	152/285 (53%)
		Pkinase	239..515	CDD:278497	150/283 (53%)
Wee1	NP_001012760.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	27..175		47/197 (24%)
		PTKc_Wee1a	292..567	CDD:271040	147/282 (52%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352323
Domainoid	1	1.000	287	1.000	Domainoid score	I1520
eggNOG	1	0.900	-	-		E1_KOG0601
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31152
Inparanoid	1	1.050	371	1.000	Inparanoid score	I2062
OMA	1	1.010	-	-		QHG46922
OrthoDB	1	1.010	-	-		D1063695at2759
OrthoFinder	1	1.000	-	-		FOG0003577
OrthoInspector	1	1.000	-	-		otm46321
orthoMCL	1	0.900	-	-		OOG6_104316
Panther	1	1.100	-	-	O	PTHR11042
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1559
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770