Protein Alignment Wee1 and EIF2AK1

DIOPT Version :9

• Sequence 1: NP_001260167.1
• Gene: Wee1 / 33965
• FlyBaseID: FBgn0011737
• Length: 609
• Species: Drosophila melanogaster
• Sequence 2: NP_055228.2
• Gene: EIF2AK1 / 27102
• HGNCID: 24921
• Length: 630
• Species: Homo sapiens
• Alignment Length: 609
• Identity: 116/609 - (19%)
• Similarity: 186/609 - (30%)
• Gaps: 286/609 - (46%)

  Fly   137 FRLSERPRSLPLHNRKLPTQDTANVNPFTPDSLMAHNKKRCRTQFGRENLNLNVNAMQKYLLSDA 201
            |..|:...||.||:.:..|.            ||...|:|.|                    .|.
Human   107 FTCSDEFSSLRLHHNRAITH------------LMRSAKERVR--------------------QDP 139

  Fly   202 CDDDVTEEAGDSMREIHQQAPKRLALHDTNISRFKREFMQVNVIGVGEFGVVFQCVNRLDGCIYA 266
            |:|         :..|.:...:.:|| :...||:..||.::.::|.|.:|.|::..|:|||..||
Human   140 CED---------ISRIQKIRSREVAL-EAQTSRYLNEFEELAILGKGGYGRVYKVRNKLDGQYYA 194

  Fly   267 IKKSKKPVAGSSFEKRALNEVWAHAVLGKHDNVVRYYSAWAEDDHML------------------ 313
            |||.....|..:...:.|.||...|.| :|.|:|.|::||.|..|::
Human   195 IKKILIKGATKTVCMKVLREVKVLAGL-QHPNIVGYHTAWIEHVHVIQPRADRAAIELPSLEVLS 258

  Fly   314 ----------IQNE----------------------------------------FCDGGSLHARI 328
                      ::|:                                        ..:.|.|.:.:
Human   259 DQEEDREQCGVKNDESSSSSIIFAEPTPEKEKRFGESDTENQNNKSVKYTTNLVIRESGELESTL 323

  Fly   329 Q------------------------DHC-----------------LGEAELKIVLM-HV------ 345
            :                        .|.                 ||:.|.:..|| |:
Human   324 ELQENGLAGLSASSIVEQQLPLRRNSHLEESFTSTEESSEENVNFLGQTEAQYHLMLHIQMQLCE 388

  Fly   346 --------------------------------------IEGLRYIHSNDLVHMDLKPENIFSTMN 372
                                                  :||:.|||:..:||.||||.|||
Human   389 LSLWDWIVERNKRGREYVDESACPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNIF---- 449

  Fly   373 PNAHKLVEVQPQQTKDDDGMDSVYEELRHSENLVTYKIGDLG----------------------- 414
                  :....||.                      ||||.|
Human   450 ------LHGPDQQV----------------------KIGDFGLACTDILQKNTDWTNRNGKRTPT 486

  Fly   415 HVTSVKEPYVEEGDCRYL-PKEILHEDYSNLFKADIFSLGITLFEAAGGGPLPKNGPEWH----- 473
            |.:.|       |.|.|. |:::...:|.  .|:|::|||:.|.|.     ....|.|..
Human   487 HTSRV-------GTCLYASPEQLEGSEYD--AKSDMYSLGVVLLEL-----FQPFGTEMERAEVL 537

  Fly   474 -NLRDGKVPILPSLSRDF---NELIAQMMHPYPDKRPTSQSIFSHPILSAVDSKSKLQLGLELTV 534
             .||.|::|  .||.:..   .:.|..:......:||::..:....:.   .:...:.|.|::.:
Human   538 TGLRTGQLP--ESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQSELF---QNSGNVNLTLQMKI 597

  Fly   535 EKRKNEILMNKLREAKKQIKLLEQ 558
            .:::.||     .|.|||:.||.|
Human   598 IEQEKEI-----AELKKQLNLLSQ 616

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wee1	NP_001260167.1	PTKc_Wee1	238..516	CDD:270953	85/464 (18%)
		Pkinase	239..515	CDD:278497	84/462 (18%)
EIF2AK1	NP_055228.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..40
		STKc_EIF2AK1_HRI	160..581	CDD:270951	87/469 (19%)
		S_TKc	167..583	CDD:214567	84/464 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	259..301		1/41 (2%)
		HRM 1	410..415		0/4 (0%)
		HRM 2	552..557		0/4 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158337
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930