DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wee1 and mik1

DIOPT Version :9

Sequence 1:	NP_001260167.1	Gene:	Wee1 / 33965	FlyBaseID:	FBgn0011737	Length:	609	Species:	Drosophila melanogaster
Sequence 2:	NP_595093.1	Gene:	mik1 / 2540885	PomBaseID:	SPBC660.14	Length:	581	Species:	Schizosaccharomyces pombe

Alignment Length:	611	Identity:	143/611 - (23%)
Similarity:	224/611 - (36%)	Gaps:	177/611 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SEHEMSVTSLDSSVEL-----RSRSP-SPQVFNPRKLR---------FADDDFD----------- 44
            |.||.:.:...|.:..     ..||| :|...|.:.:|         |.:.|.|
pombe    42 SGHEENQSHKSSKLTFFKPSNTKRSPHTPMQNNAKAIRLSTTVRHGIFKNSDLDGCSKPFAFSSG 106

  Fly    45 ----KDTPEGASPQHPLQQR--PKLSSGEEQQLDSKIGK----EGG-DGDVSMSP--PCQKVRAL 96
                |...:.::|....::|  ..||:|    |.||..|    ||. ....|..|  ||:|...:
pombe   107 LKLSKKIVDASTPIDLKRKRAVTSLSTG----LLSKREKWSLWEGNLTNPRSEQPHTPCKKGTKI 167

  Fly    97 RLF--STPATPKTI----------------LQKSTTQCSNHLSAAAAAVNASRRSDDLFRLSERP 143
            :|.  .:|.:|.|.                |....:..|:.........:.|..|:||....|.|
pombe   168 KLKPPQSPLSPTTSLLARKCKHIDLDTFSRLDHPNSDSSDETFEMEELPSLSYGSEDLLEFCETP 232

  Fly   144 -RSLPL-----HNRKLPTQDTANVNPFTPDSLMAHNKKRCRTQFGRENLNLNVNAMQKYLLSDAC 202
             :|.|:     |......:|..:...:||.|                .:.||:|:.
pombe   233 CKSQPIFLSSSHVNNWDEKDVPSSLSWTPTS----------------PIFLNINSA--------- 272

  Fly   203 DDDVTEEAGDSMREIHQQAPKRLALHDTNISRFKREFMQVNVIGVGEFGVVF--QCVNRLDGCIY 265
             ||..||                   :...|..:..|.||..|...:|..|:  ..:|.....:|
pombe   273 -DDYEEE-------------------EDWTSDLRIRFQQVKPIHESDFSFVYHVSSINPPTETVY 317

  Fly   266 AIKKSKKPVAGSSFEKRALNEVWAHAVLGKHDNVVRYYSAWAEDDHMLIQNEFCDGGSLHARIQD 330
            .:|..||..|..:.::|.|.||.....|.....||...:.|:.:|::.:|.::|:.|.|...:.:
pombe   318 VVKMLKKNAAKFTGKERHLQEVSILQRLQACPFVVNLVNVWSYNDNIFLQLDYCENGDLSLFLSE 382

  Fly   331 HCLGEAELK------IVLMHVIEGLRYIHSNDLVHMDLKPENIFSTMNPNAHKLVEVQPQQTKDD 389
              ||..::.      .:|..:.:.|.:||..:.||:|:||.|:..|.:.|
pombe   383 --LGLLQVMDPFRVWKMLFQLTQALNFIHLLEFVHLDVKPSNVLITRDGN--------------- 430

  Fly   390 DGMDSVYEELRHSENLVTYKIGDLGHVTS--VKEPYVEEGDCRYLPKEIL-HEDYSNLFKADIFS 451
                              .|:||.|..||  |......|||..|:..||| ..:|..  .||::|
pombe   431 ------------------LKLGDFGLATSLPVSSMVDLEGDRVYIAPEILASHNYGK--PADVYS 475

  Fly   452 LGITLFEAAGGGPLPKNGPEWHNLRDGKVPILPSL-----------------SRDFNELIAQMMH 499
            ||:::.|||....||:||.||..||.|....||:|                 :.....|:.:|.|
pombe   476 LGLSMIEAATNVVLPENGVEWQRLRSGDYSNLPNLKDLLLSKEKVQINKVRCAESLQCLLQRMTH 540

  Fly   500 PYPDKRPTSQSIFSHPILSAVDSKSK 525
            ||.|.|||:|.:.:.|.:..:...|:
pombe   541 PYVDCRPTTQDLLAMPEMIFISEHSQ 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wee1	NP_001260167.1	PTKc_Wee1	238..516	CDD:270953	84/305 (28%)
Wee1	NP_001260167.1	Pkinase	239..515	CDD:278497	84/303 (28%)
mik1	NP_595093.1	PTKc_Wee1_fungi	288..556	CDD:270954	84/304 (28%)
mik1	NP_595093.1	S_TKc	300..556	CDD:214567	80/292 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0601
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1671
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840