DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wee1 and wee1

DIOPT Version :9

Sequence 1:	NP_001260167.1	Gene:	Wee1 / 33965	FlyBaseID:	FBgn0011737	Length:	609	Species:	Drosophila melanogaster
Sequence 2:	NP_587933.1	Gene:	wee1 / 2539123	PomBaseID:	SPCC18B5.03	Length:	877	Species:	Schizosaccharomyces pombe

Alignment Length:	622	Identity:	157/622 - (25%)
Similarity:	243/622 - (39%)	Gaps:	158/622 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAFRQSEHEMSV-------TSLDSSVELRSRSPS----PQVFNPRKLRFADDDFDKDTPEGAS-- 52
            :.|..|:.:.:|       :|.|:|..::|..||    ||........|:|:.....:....|
pombe   288 LGFASSQTKSAVSNNHSRNSSKDASFMMKSFIPSNRSHPQTQQNESSLFSDNSMVNSSSNSFSLF 352

  Fly    53 PQHPLQQRP--KLSSGEEQQLDSKIGKEGGDGDVSMSPPCQKVRALRLFS-----------TPAT 104
            |...|...|  :|.:...||:               .||.|...:..|.|           ||..
pombe   353 PNATLPNPPSSELLTTPFQQI---------------KPPSQVFMSTGLLSKQHRPRKNINFTPLP 402

  Fly   105 PKTILQKST---TQCSNHLSAAAAAVNASRRSDDLFRLSERPRSLPLHNRKLPT-------QDTA 159
            |.|..:.||   ...|:..|..:.:..::.::|..|...|   :.|.::..:||       .|..
pombe   403 PSTPSKPSTFVRPHSSSTDSPPSPSTPSNTQTDSYFIQRE---NTPTNHNSIPTIQLEKSSMDFL 464

  Fly   160 NVNPFTPDSLM--AHN-------KKRC-----RTQFGREN-LNLNVNAMQKYLLSDACDDDVT-- 207
            ..:|  |.|.:  :||       .:||     |..|..|| ::::::..|...:....::.::
pombe   465 RFDP--PPSAVKTSHNYGLPFLSNQRCPATPTRNPFAFENTVSIHMDGRQPSPIKSRNNNQMSFA 527

  Fly   208 --EEAGDSMREIHQQAPKRLALH----------DTNISRFKREFMQVNVIGVGEFGVVFQCVNRL 260
              |||     ::.|.:.....|.          .::.|.....|..|.::|.|||..|||..:.:
pombe   528 MEEEA-----DVSQPSSSSFTLSFPSALTSSKVSSSTSHLLTRFRNVTLLGSGEFSEVFQVEDPV 587

  Fly   261 DGCI-YAIKKSKKPVAGSSFEKRALNEVWAHAVLGKHDNVVRYYSAWAEDDHMLIQNEFCDGGSL 324
            :..: ||:||.|...:|.....|.|.||.....|..||::|....:|.....:.:|.|.|:.|||
pombe   588 EKTLKYAVKKLKVKFSGPKERNRLLQEVSIQRALKGHDHIVELMDSWEHGGFLYMQVELCENGSL 652

  Fly   325 HARIQDH----CLGEAELKIVLMHVIEGLRYIHSNDLVHMDLKPENIFSTMNPNAHKLVEVQPQQ 385
            ...:::.    .|.|..:..:|:.|..||::||..:.||:||||.|:..|.
pombe   653 DRFLEEQGQLSRLDEFRVWKILVEVALGLQFIHHKNYVHLDLKPANVMITF-------------- 703

  Fly   386 TKDDDGMDSVYEELRHSENLVTYKIGDLG--HVTSVKEPYVEEGDCRYLPKEILHEDYSNLF--K 446
                :|               |.||||.|  .|..|......||||.|:..|:|   .::|:  .
pombe   704 ----EG---------------TLKIGDFGMASVWPVPRGMEREGDCEYIAPEVL---ANHLYDKP 746

  Fly   447 ADIFSLGITLFEAAGGGPLPKNGPEWHNLRDGKVPILPSLS--------------RDFNELIAQ- 496
            |||||||||:||||....||.||..|..||.|.:...|.||              ...|.:|.|
pombe   747 ADIFSLGITVFEAAANIVLPDNGQSWQKLRSGDLSDAPRLSSTDNGSSLTSSSRETPANSIIGQG 811

  Fly   497 --------MMHPYPDKRPTSQSIFSHPILSAVDSKSK 525
                    |:.|.|..|||...|.:...:..|:.:.|
pombe   812 GLDRVVEWMLSPEPRNRPTIDQILATDEVCWVEMRRK 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wee1	NP_001260167.1	PTKc_Wee1	238..516	CDD:270953	97/309 (31%)
Wee1	NP_001260167.1	Pkinase	239..515	CDD:278497	97/307 (32%)
wee1	NP_587933.1	PTKc_Wee1_fungi	565..838	CDD:270954	97/308 (31%)
wee1	NP_587933.1	Pkinase	566..836	CDD:278497	97/305 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0601
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1671
SonicParanoid	1	1.000	-	-		X1559
TreeFam	0	0.000	Not matched by this tool.
	4	3.840