Protein Alignment Wee1 and Wee1

DIOPT Version :9

• Sequence 1: NP_001260167.1
• Gene: Wee1 / 33965
• FlyBaseID: FBgn0011737
• Length: 609
• Species: Drosophila melanogaster
• Sequence 2: NP_033542.2
• Gene: Wee1 / 22390
• MGIID: 103075
• Length: 646
• Species: Mus musculus
• Alignment Length: 657
• Identity: 247/657 - (37%)
• Similarity: 343/657 - (52%)
• Gaps: 128/657 - (19%)

  Fly     2 AFRQSEHEM--SVTSLDSSVELRSRSPSPQVFNPRKLRFADDDF------------------DKD 46
            ||::.:..:  :.:..::..|.|.|||..:..:|.:|   :||.                  |..
Mouse    53 AFQEPDSPLPSARSPAEAEAERRRRSPGAEPSSPGEL---EDDLLLQGGGGGAQAAGGGAEGDSW 114

  Fly    47 TPEGASPQHPLQQRPKLSSGEEQQLDSKIG--KEGGDGDVS---------------------MSP 88
            ..||.....|::     |......|.|...  :.||.||.|                     .:|
Mouse   115 EEEGFGSSSPVK-----SPSTAYFLSSPFSPVRCGGPGDASPQGCGAPRAMDDPCSPQPDYPSTP 174

  Fly    89 PCQKVRALRLFSTPATPKTILQKSTTQCSNHLSAAAAAVNASRRSDDLFRLSERPRSLPLHNRKL 153
            |.:..|.||||.||.|||::|.|:....|.         :...|...||..:|:........|:.
Mouse   175 PHKTFRKLRLFDTPHTPKSLLSKARVIDSG---------SVKLRGSSLFMDTEKSGKREFDTRQT 230

  Fly   154 PTQDTANVNPFTPDSLMAHNKKRCRTQFGRENLNLNVNAMQKYLLSDACDDDVTEEAGDSMREIH 218
            |   ..|:||||||.::.|:..|||   ||:....|          |:.:|   .||.|...|..
Mouse   231 P---QVNINPFTPDPVLLHSSGRCR---GRKRAYFN----------DSSED---MEASDYEFEDE 276

  Fly   219 QQAPKRLALHDTNI-SRFKREFMQVNVIGVGEFGVVFQCVNRLDGCIYAIKKSKKPVAGSSFEKR 282
            .:..||:.:.::|: ||:..||.::..||.||||.||:||.||||||||||:||||:|||..|:.
Mouse   277 TRPAKRITITESNMKSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQN 341

  Fly   283 ALNEVWAHAVLGKHDNVVRYYSAWAEDDHMLIQNEFCDGGSLHARIQDH-----CLGEAELKIVL 342
            ||.||:||||||:|.:||||:||||||||||||||:|:||||...|.::     .|.|.|||.:|
Mouse   342 ALREVYAHAVLGQHPHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRVMSYLTEVELKDLL 406

  Fly   343 MHVIEGLRYIHSNDLVHMDLKPENIF--STMNPNAHKLVEVQPQQTKDDDGMDSVYEELRHSENL 405
            :.|..|||||||..|||||:||.|||  .|..|||     |..:..:||           ...|.
Mouse   407 LQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNA-----VSEEGDEDD-----------WISNK 455

  Fly   406 VTYKIGDLGHVTSVKEPYVEEGDCRYLPKEILHEDYSNLFKADIFSLGITLFEAAGGGPLPKNGP 470
            |.:|||||||||.:..|.|||||.|:|..|:|.|:||:|.|||||:|.:|:..|||..|||:||.
Mouse   456 VMFKIGDLGHVTRISSPQVEEGDSRFLANEVLQENYSHLPKADIFALALTVVCAAGAEPLPRNGE 520

  Fly   471 EWHNLRDGKVPILPS-LSRDFNELIAQMMHPYPDKRPTSQSIFSHPILSAVDSKSKLQLGLELTV 534
            :||.:|.|::|.:|. ||::..||:..|:||.|::||::..:..|.:|.:...||..||.:||..
Mouse   521 QWHEIRQGRLPRIPQVLSQEVTELLRVMIHPDPERRPSAMELVKHSVLLSASRKSAEQLRIELNA 585

  Fly   535 EKRKNEILMNKLREAKKQIKLLEQRVNLLAVTNNPDSLDGQRCLRSFTRRMRTPFSSHGKFDSIS 599
            ||.||.:|..:|::|:...|:..:                :|.|  ||.||.|..::.      |
Mouse   586 EKFKNSLLQKELKKAQMAAKVAAE----------------ERAL--FTDRMATRSTTQ------S 626

  Fly   600 DRNKNVI 606
            :|...:|
Mouse   627 NRTSRLI 633

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wee1	NP_001260167.1	PTKc_Wee1	238..516	CDD:270953	153/285 (54%)
		Pkinase	239..515	CDD:278497	151/283 (53%)
Wee1	NP_033542.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..178		38/167 (23%)
		PTKc_Wee1a	292..567	CDD:271040	151/282 (54%)
		Pkinase	298..568	CDD:278497	149/277 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848735
Domainoid	1	1.000	288	1.000	Domainoid score	I1562
eggNOG	1	0.900	-	-		E1_KOG0601
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31152
Inparanoid	1	1.050	370	1.000	Inparanoid score	I2117
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46922
OrthoDB	1	1.010	-	-		D1063695at2759
OrthoFinder	1	1.000	-	-		FOG0003577
OrthoInspector	1	1.000	-	-		otm44224
orthoMCL	1	0.900	-	-		OOG6_104316
Panther	1	1.100	-	-	O	PTHR11042
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1671
SonicParanoid	1	1.000	-	-		X1559
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800