DRSC/TRiP Functional Genomics Resources

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Protein Alignment Wee1 and Eif2ak2

DIOPT Version :10

Sequence 1:NP_477035.1 Gene:Wee1 / 33965 FlyBaseID:FBgn0011737 Length:609 Species:Drosophila melanogaster
Sequence 2:XP_006523926.1 Gene:Eif2ak2 / 19106 MGIID:1353449 Length:529 Species:Mus musculus


Alignment Length:536 Identity:123/536 - (22%)
Similarity:196/536 - (36%) Gaps:178/536 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    40 DDDFDKDTPEGASPQ-----------HPLQQRPKLSSGEEQ-----QLDS------KIGKE-GGD 81
            |::...|....||.|           :...|:.|||...||     :|..      |||:. .|.
Mouse    89 DNENKVDCHTSASEQGLFVGNYIGLVNSFAQKKKLSVNYEQCEPNSELPQRFICKCKIGQTMYGT 153

  Fly    82 GDVSMSPPCQKVRALRLF-----STPATPKTILQKSTTQCSNHLSAAAAAVNASRRSDDLFRLSE 141
            |........:::.|...:     |.|.|..|.....|:..|...|:::...|...:|        
Mouse   154 GSGVTKQEAKQLAAKEAYQKLLKSPPKTAGTSSSVVTSTFSGFSSSSSMTSNGVSQS-------- 210

  Fly   142 RPRSLPLHNRKLPTQDTANVNPFTPDSLMAHNKKRCRTQFGRENLNLNVNAMQKYLLSDACDDDV 206
            .|.|.            ::.|.||  :.:..||::...:...:::..|     ||.|.       
Mouse   211 APGSF------------SSENVFT--NGLGENKRKSGVKVSPDDVQRN-----KYTLD------- 249

  Fly   207 TEEAGDSMREIHQQAPKRLALHDTNISRFKREFMQVNVIGVGEFGVVFQCVNRLDGCIYAIKKSK 271
                                      :||..:|..:..||:|.||.||:..:|:||..||||:.|
Mouse   250 --------------------------ARFNSDFEDIEEIGLGGFGQVFKAKHRIDGKRYAIKRVK 288

  Fly   272 KPVAGSSFEKRALNEVWAHAVLGKHDNVVRYYSAWAEDDH----------------MLIQNEFCD 320
            .....:..|.:||.|:       .|.|:|:|:|.|...|:                :.||.||||
Mouse   289 YNTEKAEHEVQALAEL-------NHVNIVQYHSCWEGVDYDPEHSMSDTSRYKTRCLFIQMEFCD 346

  Fly   321 GGSLHARIQDHCLGEAELKIVL---MHVIEGLRYIHSNDLVHMDLKPENIFSTMNPNAHKLVEVQ 382
            .|:|...:::....:.:..::|   ..::.|:.||||..|:|.||||.|||         ||:. 
Mouse   347 KGTLEQWMRNRNQSKVDKALILDLYEQIVTGVEYIHSKGLIHRDLKPGNIF---------LVDE- 401

  Fly   383 PQQTKDDDGMDSVYEELRHSENLVTYKIGDLGHVTSV----KEPYVEEGDCRYL-PKEILHEDYS 442
                             ||      .||||.|..|::    |......|..:|: |:::..:.|.
Mouse   402 -----------------RH------IKIGDFGLATALENDGKSRTRRTGTLQYMSPEQLFLKHYG 443

  Fly   443 NLFKADIFSLGITLFEAAGGGPLPKNGPEWHN--LRDGKVPILPSLSR-DFN---------ELIA 495
            .  :.|||:||:.|.|..            |.  ....|:....||.: ||:         .|:.
Mouse   444 K--EVDIFALGLILAELL------------HTCFTESEKIKFFESLRKGDFSNDIFDNKEKSLLK 494

  Fly   496 QMMHPYPDKRPTSQSI 511
            :::...|..||.:..|
Mouse   495 KLLSEKPKDRPETSEI 510

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Wee1NP_477035.1 PTKc_Wee1 238..516 CDD:270953 83/310 (27%)
Eif2ak2XP_006523926.1 DSRM_EIF2AK2_rpt1 21..88 CDD:380732
DSRM_EIF2AK2_rpt2 108..175 CDD:380733 13/66 (20%)
Protein Kinases, catalytic domain 249..514 CDD:473864 85/349 (24%)
Blue background indicates that the domain is not in the aligned region.

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