Protein Alignment Wee1 and Eif2ak1

DIOPT Version :9

• Sequence 1: NP_001260167.1
• Gene: Wee1 / 33965
• FlyBaseID: FBgn0011737
• Length: 609
• Species: Drosophila melanogaster
• Sequence 2: NP_038585.2
• Gene: Eif2ak1 / 15467
• MGIID: 1353448
• Length: 619
• Species: Mus musculus
• Alignment Length: 584
• Identity: 114/584 - (19%)
• Similarity: 188/584 - (32%)
• Gaps: 239/584 - (40%)

  Fly   137 FRLSERPRSLPLHNRKLPTQDTANVNPFTPDSLMAHNKKRCRTQFGRENLNLNVNAMQKYLLSDA 201
            |..|:...||.||:.:..|.            ||...|:|.|                    .|.
Mouse   107 FTCSDEFSSLRLHHNRAITH------------LMRSAKERVR--------------------QDP 139

  Fly   202 CDDDVTEEAGDSMREIHQQAPKRLALHDTNISRFKREFMQVNVIGVGEFGVVFQCVNRLDGCIYA 266
            |.|:          ...|:...|....:...||:..||.::.::|.|.:|.|::..|:|||..||
Mouse   140 CQDN----------SYMQKIRSREIAFEAQTSRYLNEFEELAILGKGGYGRVYKVRNKLDGQHYA 194

  Fly   267 IKKSKKPVAGSSFEKRALNEVWAHAVLGKHDNVVRYYSAWAEDDHML------------------ 313
            |||.....|..:...:.|.||...|.| :|.|:|.|::||.|..|::
Mouse   195 IKKILIKSATKTDCMKVLREVKVLAGL-QHPNIVGYHTAWIEHVHVVQPQDRVPIQLPSLEVLSE 258

  Fly   314 ------------------------------------IQNEFCDGGSLHARI-------------- 328
                                                ::||..:..|..|.:
Mouse   259 QEGDRDQGGVKDNESSSSIVFAELTPEKEKPFGESEVKNENNNLVSYTANLVVRNSSESESSIEL 323

  Fly   329 -QD--------------------------------------HCLGEAELKIVLM-HV-------- 345
             :|                                      :.||:.|::..|| |:
Mouse   324 QEDGLTDLSVRPVVRHQLPLGHSSELEGNFTSTDESSEGNLNLLGQTEVRYHLMLHIQMQLCELS 388

  Fly   346 ------------------------------------IEGLRYIHSNDLVHMDLKPENIFSTMNPN 374
                                                :||:.|||:..:||.||||.|||
Mouse   389 LWDWITERNKRSREYVDEAACPYVMASVATKIFQELVEGVFYIHNMGIVHRDLKPRNIF------ 447

  Fly   375 AHKLVEVQPQQTKDDDGMDSVYEELRHSENLVTYKIGDLGHVTSVKEPYVEEGDCRYL-PKEILH 438
                :....||.|..|...:..:.:::::.......|...|.:.|       |.|.|. |:::..
Mouse   448 ----LHGPDQQVKIGDFGLACADIIQNADWTNRNGKGTRTHTSRV-------GTCLYASPEQLEG 501

  Fly   439 EDYSNLFKADIFSLGITLFEAAGGGPLPKNGPEWH------NLRDGKVPILPSLSRDF---NELI 494
            ..|.  .|:|::|||:.|.|.     ....|.|..      .:|.|::|  .|||:..   .:.|
Mouse   502 SQYD--AKSDMYSLGVILLEL-----FQPFGTEMERATVLTGVRTGRIP--ESLSKRCPVQAKYI 557

  Fly   495 AQMMHPYPDKRPTSQSIFSHPILSAVDSKSKLQLGLELTVEKRKNEILMNKLREAKKQIKLLEQ 558
            ..:......:||::..:....:.   .:...:.|.|::.:.:::.||     .|.|||:.||.|
Mouse   558 QLLTGRNVSQRPSALQLLQSELF---QTTGNVNLTLQMKIIEQEKEI-----EELKKQLSLLSQ 613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wee1	NP_001260167.1	PTKc_Wee1	238..516	CDD:270953	84/439 (19%)
		Pkinase	239..515	CDD:278497	83/437 (19%)
Eif2ak1	NP_038585.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..40
		STKc_EIF2AK1_HRI	160..578	CDD:270951	86/444 (19%)
		Pkinase	167..580	CDD:278497	83/439 (19%)
		HRM 1	408..413		0/4 (0%)
		HRM 2	549..554		0/4 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848733
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930