Protein Alignment Wee1 and Eif2ak3

DIOPT Version :9

• Sequence 1: NP_001260167.1
• Gene: Wee1 / 33965
• FlyBaseID: FBgn0011737
• Length: 609
• Species: Drosophila melanogaster
• Sequence 2: NP_034251.2
• Gene: Eif2ak3 / 13666
• MGIID: 1341830
• Length: 1114
• Species: Mus musculus
• Alignment Length: 610
• Identity: 107/610 - (17%)
• Similarity: 172/610 - (28%)
• Gaps: 314/610 - (51%)

  Fly   166 PDSLMAHNKKRCRTQFGRENLNLNVNAMQKYLLSDACDDDVTEEAGDSMREIHQQAPKRLALHDT 230
            |......::.:|:|:             .||   |:...||::.:.:.|:            :..
Mouse   544 PHRQRKESETQCQTE-------------SKY---DSVSADVSDNSWNDMK------------YSG 580

  Fly   231 NISRFKREFMQVNVIGVGEFGVVFQCVNRLDGCIYAIKKSKKPVAGSSFEKRALNEVWAHAVLGK 295
            .:||:..:|..:..:|.|.|||||:..|::|.|.||||:.:.|....:.|| .:.||.|.|.| :
Mouse   581 YVSRYLTDFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREK-VMREVKALAKL-E 643

  Fly   296 HDNVVRYYSAWAED---------DHMLIQNEF----------CDGGSLHAR-------------- 327
            |..:|||::||.|.         |.:.:::|.          .|..|:..|
Mouse   644 HPGIVRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKEQIEVI 708

  Fly   328 ------------------------------------------------IQDHCLGEAE------- 337
                                                            :||.||.:.|
Mouse   709 APSPERSRSFSVGISCGQTSSSESQFSPLEFSGTDCGDNSDSADAAYNLQDSCLTDCEDVEDGTV 773

  Fly   338 ---------------------------------------------------------------LK 339
                                                                           ||
Mouse   774 DGNDEGHSFELCPSEASPYTRSREGTSSSIVFEDSGCGNASSKEEPRGNRLHDGNHYVNKLTDLK 838

  Fly   340 I---------------------------------------------------------------- 340
            .
Mouse   839 CSSSRSSSEATTLSTSPTRPTTLSLDFTKNTVGQLQPSSPKVYLYIQMQLCRKENLKDWMNRRCS 903

  Fly   341 -----------VLMHVIEGLRYIHSNDLVHMDLKPENIFSTMNPNAHKLVEVQPQQTKDDDGMDS 394
                       :.:.:.|.:.::||..|:|.||||.|||.||                 ||
Mouse   904 LEDREHGVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTM-----------------DD---- 947

  Fly   395 VYEELRHSENLVTYKIGDLGHVTSVKEPYVEE----------------GDCRYLPKEILH-EDYS 442
                        ..|:||.|.||::.:...|:                |...|:..|.:| .:||
Mouse   948 ------------VVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYMSPEQIHGNNYS 1000

  Fly   443 NLFKADIFSLGITLFEAAGGGPLPKNGPEWH---NLRDGKVPILPSLSRDFNELIAQ-MMHPYPD 503
            :  |.||||||:.|||..  .|.........   ::|:.|.|:|.:.......::.| |:.|.|.
Mouse  1001 H--KVDIFSLGLILFELL--YPFSTQMERVRILTDVRNLKFPLLFTQKYPQEHMMVQDMLSPSPT 1061

  Fly   504 KRPTSQSIFSHPILSAVDSKSKLQL 528
            :||.:..|..:.|...::...|..|
Mouse  1062 ERPEATDIIENAIFENLEFPGKTVL 1086

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wee1	NP_001260167.1	PTKc_Wee1	238..516	CDD:270953	93/524 (18%)
		Pkinase	239..515	CDD:278497	93/522 (18%)
Eif2ak3	NP_034251.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	72..92
		Luminal_EIF2AK3	100..416	CDD:188874
		PKc_like	583..>671	CDD:304357	33/89 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	775..827		0/51 (0%)
		STKc_EIF2AK3_PERK	<874..1073	CDD:270950	51/235 (22%)
		S_TKc	<879..1071	CDD:214567	51/228 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1087..1114		107/610 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848730
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930