DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wee1 and pkmyt1

DIOPT Version :9

Sequence 1:	NP_001260167.1	Gene:	Wee1 / 33965	FlyBaseID:	FBgn0011737	Length:	609	Species:	Drosophila melanogaster
Sequence 2:	XP_012825559.1	Gene:	pkmyt1 / 100145798	XenbaseID:	XB-GENE-969853	Length:	603	Species:	Xenopus tropicalis

Alignment Length:	506	Identity:	128/506 - (25%)
Similarity:	202/506 - (39%)	Gaps:	108/506 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 GASPQHPLQQRPKLSSGEEQQLDSKIGKEGGDGDVSMSPPCQKVRALRLFSTPA-----TPKTIL 109
            |.:.:|.:...|.:..|......|.:..:...|....||    :..|.:...|.     ||   |
Frog    10 GGAGRHLVCGIPGIVGGAASPPKSPVSPKSEQGPPLHSP----LTCLLIMPVPGDDMGDTP---L 67

  Fly   110 QKSTTQCSNHLSAAAAAVNASRRSDDLFRLSERPRSLPLHNRKLPTQDTANVNPFTPDSLMAHNK 174
            .::......|.|.|          :..|.|.:|.|||..   .||.:..  |....|.|.:..||
Frog    68 TRTPIPVPAHFSQA----------EQSFSLKKRGRSLCY---TLPPRPP--VKSALPISRLFPNK 117

  Fly   175 KRCRTQFGRENLNLNVNAMQKYLLSDACDDDVTEEAGDSMREIHQQAPKRLALHDTNISR--FKR 237
            :|..:|...:::                          |.|. .|..|....|:|.:...  ||:
Frog   118 QRSWSQPRPQSV--------------------------SFRS-PQNNPPASELYDQSKGETFFKQ 155

  Fly   238 EFMQVNVIGVGEFGVVFQCVNRLDGCIYAIKKSKKPVAGSSFEKRALNEVWAHAVLGKHDNVVRY 302
            .|..:..:|.|.||.|::..:..|||.||:|:|..|..|.|..:|.|.||..|..:|.|.|.:|:
Frog   156 CFRSICKLGRGSFGEVYKVQSLEDGCFYAVKRSVSPFRGESDRQRKLQEVRKHERVGVHPNCLRF 220

  Fly   303 YSAWAEDDHMLIQNEFCDGGSLHARIQDHC------LGEAELKIVLMHVIEGLRYIHSNDLVHMD 361
            ..||.|...:.:|.|.|.|.     :|.|.      |...::..:...::.||:::|..:|:|:|
Frog   221 VRAWEEKRLLYLQTELCAGS-----LQQHSEEFSGPLPPRKIWNITCDLLHGLKHLHDRNLLHLD 280

  Fly   362 LKPENIFSTMNPNAHKLVEVQPQQTKDDDGMDSVYEELRHSENLVTYKIGDLGHVTSVK----EP 422
            :||.|:|.:.:.                                 ..|:||.|.:..:.    ..
Frog   281 IKPANVFISFSG---------------------------------VCKLGDFGLMVELDGTEGSG 312

  Fly   423 YVEEGDCRYLPKEILHEDYSNLFKADIFSLGITLFEAAGGGPLPKNGPEWHNLRDGKVP--ILPS 485
            ..:|||.||:..|:|...:|.  .||:||||::|.|.|....|||:|..|..||.|::|  ....
Frog   313 EAQEGDPRYMAPELLDGIFSK--AADVFSLGMSLLEVACNMELPKSGDGWQQLRQGRLPTEFTSD 375

  Fly   486 LSRDFNELIAQMMHPYPDKRPTSQSIFSHPILSAVDSKSKLQLGLELTVEK 536
            |..||.:::|.|:.|...:|.|...:.|.|.:...:....:.|..|.|:.|
Frog   376 LPPDFLKVLAAMLEPDYRRRATVDWLLSLPAIRNAERWRMVTLAQERTLGK 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wee1	NP_001260167.1	PTKc_Wee1	238..516	CDD:270953	84/289 (29%)
Wee1	NP_001260167.1	Pkinase	239..515	CDD:278497	84/287 (29%)
pkmyt1	XP_012825559.1	PKc_Myt1	155..405	CDD:270952	84/289 (29%)
pkmyt1	XP_012825559.1	Pkinase	162..405	CDD:278497	83/282 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1063695at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010