DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wee1 and wee2

DIOPT Version :9

Sequence 1:	NP_001260167.1	Gene:	Wee1 / 33965	FlyBaseID:	FBgn0011737	Length:	609	Species:	Drosophila melanogaster
Sequence 2:	NP_001096499.1	Gene:	wee2 / 100125126	XenbaseID:	XB-GENE-5560750	Length:	562	Species:	Xenopus tropicalis

Alignment Length:	561	Identity:	216/561 - (38%)
Similarity:	284/561 - (50%)	Gaps:	109/561 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 DF-DKDTPEGASP-----QHPLQQRPKLSSGEEQQLDSKIGKEGGDGDVSMS----PPCQKV--- 93
            || ..|..:|.||     .|..|:...::|.........|..:..:..:|.|    .||...
Frog    16 DFSSSDEEDGMSPGLEEGSHSNQRGSPVNSWRANNCPFPITPQRNERGLSPSQEELSPCSDYSPV 80

  Fly    94 --------------------RALRLFSTPATPKTILQK------STTQC-SNHLSAAAAAVNASR 131
                                :.|:|..||.|||::|.|      |..|| ...|....|...|
Frog    81 PSDKGVGGECPGTPLHYSTWKKLKLCDTPYTPKSLLYKTLPSPGSRVQCRGQRLLRFVAGTGA-- 143

  Fly   132 RSDDLFRLSERPRSLPLHNRKLPTQDTANVNPFTPDSLMAHNKKRCRTQFGRENLNLNVNAMQKY 196
                                :|......|||||||:|.              ...|.:.|..:|.
Frog   144 --------------------ELDDPALVNVNPFTPESY--------------RQANFHPNGKRKE 174

  Fly   197 LLSDACDDDVTEEAGDSMREIHQQAP-----KRLALHDTN-ISRFKREFMQVNVIGVGEFGVVFQ 255
            ...|.|      .|...|:...::.|     ||..|.:|| :||:|.||:::..||.||||.||:
Frog   175 RPEDDC------SAEPQMKYAEKEHPAVFQSKRFVLRETNMVSRYKTEFLEIEKIGAGEFGSVFK 233

  Fly   256 CVNRLDGCIYAIKKSKKPVAGSSFEKRALNEVWAHAVLGKHDNVVRYYSAWAEDDHMLIQNEFCD 320
            ||.|||||.||||:||||:|||:.|:.||.||:||||||.|.:||||||||||||||:||||:|:
Frog   234 CVKRLDGCFYAIKRSKKPLAGSTDEQLALREVYAHAVLGHHPHVVRYYSAWAEDDHMIIQNEYCN 298

  Fly   321 GGSLHARIQDH-----CLGEAELKIVLMHVIEGLRYIHSNDLVHMDLKPENIFSTMNPNAHKLVE 380
            ||||...|.::     .:.|.|||.:|:.|..||:||||:.|||||:||.|||.     ..|..|
Frog   299 GGSLQDLIMENKKEGRFVPEQELKEILLQVSMGLKYIHSSGLVHMDIKPSNIFI-----CRKQTE 358

  Fly   381 VQPQQTKDDDGMDSVYEELRHSENLVTYKIGDLGHVTSVKEPYVEEGDCRYLPKEILHEDYSNLF 445
            |...::..:|.:.|.         .|.|||||||||||:..|.|||||.|:|..|||.|||..|.
Frog   359 VGQDESDGEDDLSSA---------SVLYKIGDLGHVTSILNPQVEEGDSRFLANEILQEDYRQLP 414

  Fly   446 KADIFSLGITLFEAAGGGPLPKNGPEWHNLRDGKVPILPS-LSRDFNELIAQMMHPYPDKRPTSQ 509
            |||||:||:|:..|||.||||.|...||::|.|.:|.:|. |:..|..|:..::||.|..||.:.
Frog   415 KADIFALGLTITLAAGAGPLPCNEDSWHHIRKGNLPHIPQPLTPAFLALLKLLVHPDPVMRPPAV 479

  Fly   510 SIFSHPILSAVDSKSKLQLGLELTVEKRKNEILMNKLREAK 550
            |:..:.:|.....|: .||..:|.|||.|..:|..:|:.||
Frog   480 SLAKNSLLRRCVGKA-AQLQKQLNVEKFKTAMLERELKAAK 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wee1	NP_001260167.1	PTKc_Wee1	238..516	CDD:270953	149/283 (53%)
Wee1	NP_001260167.1	Pkinase	239..515	CDD:278497	148/281 (53%)
wee2	NP_001096499.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..86		14/69 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	161..181		5/39 (13%)
		PKc_like	216..486	CDD:389743	149/283 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	288	1.000	Domainoid score	I1550
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	359	1.000	Inparanoid score	I2160
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1063695at2759
OrthoFinder	1	1.000	-	-		FOG0003577
OrthoInspector	1	1.000	-	-		otm49397
Panther	1	1.100	-	-	LDO	PTHR11042
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1671
SonicParanoid	1	1.000	-	-		X1559
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.100