Protein Alignment Rat1 and RAT1

DIOPT Version :10

• Sequence 1: NP_609082.1
• Gene: Rat1 / 33964
• FlyBaseID: FBgn0031868
• Length: 908
• Species: Drosophila melanogaster
• Sequence 2: NP_014691.1
• Gene: RAT1 / 854213
• SGDID: S000005574
• Length: 1006
• Species: Saccharomyces cerevisiae
• Alignment Length: 1074
• Identity: 392/1074 - (36%)
• Similarity: 547/1074 - (50%)
• Gaps: 242/1074 - (22%)

  Fly     1 MGVPAFFRWLSRKYPSVIIECNENKQVDADTGRNIYEDPTLPNPNGIEFDNLYLDMNGIIHPCTH 65
            ||||:||||||||||.:|....|.:....| |..:..|.:..|||| |.||||||||||:|||:|
Yeast     1 MGVPSFFRWLSRKYPKIISPVLEEQPQIVD-GVILPLDYSASNPNG-ELDNLYLDMNGIVHPCSH 63

  Fly    66 PEDKPAPKNEDEMMVAIFECIDRLFGIVRPRKLLYMAIDGVAPRAKMNQQRSRRFRAAKET---T 127
            ||:||.|:.||||::|:||..:|:..:.||||:|.||:|||||||||||||:||||:|::.   .
Yeast    64 PENKPPPETEDEMLLAVFEYTNRVLNMARPRKVLVMAVDGVAPRAKMNQQRARRFRSARDAQIEN 128

  Fly   128 EKRLEIARIREELLSRGCKLPPEKEKGEHFDSNCITPGTPFMDRLSKCLHYFVHDRQNNNPAWKG 192
            |.|.||.|.|||:   |..:.......:.:|||.|||||||||:|:..|.|:...:...:|.||.
Yeast   129 EAREEIMRQREEV---GEIIDDAVRNKKTWDSNAITPGTPFMDKLAAALRYWTAFKLATDPGWKN 190

  Fly   193 IKVILSDANVPGEGEHKIMDYIRKQRAQPDHDPNTQHVLCGADADLIMLGLATHEPNFTIIREEF 257
            ::||:|||.||||||||||::||.|||.|:::|||.|.:.|.|||||.||||||||:|.|:||:.
Yeast   191 LQVIISDATVPGEGEHKIMNFIRSQRADPEYNPNTTHCIYGLDADLIFLGLATHEPHFKILREDV 255

  Fly   258 LPNKPRPCDICNGFGHEMDKCVGLGATAPTSANFKPDVPIGAEVK-----------FIFVRLSVL 311
            .....|..:                       |.|..:.:..|.|           |:::.::||
Yeast   256 FAQDNRKRN-----------------------NLKDTINMTEEEKQFLQKQNSEQPFLWLHINVL 297

  Fly   312 REYLKQTLEMPNLPFEYSFERALDDWVFMCFFVGNDFLPHLPSLEIREGAVDRLVELYKKCVYKT 376
            ||||...|.:|.|||.:..|||:|||||||||.|||||||||.|::||.::|.|::::|..:.|.
Yeast   298 REYLSAELWVPGLPFTFDLERAIDDWVFMCFFCGNDFLPHLPCLDVRENSIDILLDIWKVVLPKL 362

  Fly   377 RGYLTDSGDVNLDRVQLIMTDLGNAEDQIFKSRQ----RREEQFKARDKARKRQERNQD------ 431
            :.|:|..|.:||..|:.::..||:.|..|||:|.    |::|.|:.| ||:|...:.||
Yeast   363 KTYMTCDGVLNLPSVETLLQHLGSREGDIFKTRHIQEARKKEAFERR-KAQKNMSKGQDRHPTVA 426

  Fly   432 ---------HGSLNQSAFGAS--------------------AVGPNSQQRSVGN------YKEEA 461
                     .|:|.:.::..:                    |:....||....|      .|||.
Yeast   427 TEQLQMYDTQGNLAKGSWNLTTSDMVRLKKELMLANEGNEEAIAKVKQQSDKNNELMKDISKEEI 491

  Fly   462 --AALRNRKRTSDMANL--------------DDEDEE---------------------------- 482
              |..:..|...::|.:              |:|:||
Yeast   492 DDAVSKANKTNFNLAEVMKQKIINKKHRLEKDNEEEEIAKDSKKVKTEKAESECDLDAEIKDEIV 556

  Fly   483 ------ENN----------------------------DE-VRLWEDGFKDRYYESKFDVAPGN-Q 511
                  ||:                            || |:|:|.|:.:|||.:||.|.|.: :
Yeast   557 ADVNDRENSETTEVSRDSPVHSTVNVSEGPKNGVFDTDEFVKLFEPGYHERYYTAKFHVTPQDIE 621

  Fly   512 QFRYAVALQYVRGLCWVLKYYYQGCASWNWYFPYHYAPFASDFVNIQGLSTMFEKGTKPFNPLEQ 576
            |.|..:...|:.|:.|||.|||||||||||::||||||.|:||.....|...||:|| ||.|.||
Yeast   622 QLRKDMVKCYIEGVAWVLMYYYQGCASWNWFYPYHYAPLATDFHGFSHLEIKFEEGT-PFLPYEQ 685

  Fly   577 LMGVFPAASSSHVPEPWAKLMSDPESPIIDFYPEDFKIDLNGKKFAWQGVALLPFVDEKRLFKAL 641
            ||.|.||||...:|:.:..|||:|:|.|||||||:|.||:||||.:|||:|||||:|:.||..|:
Yeast   686 LMSVLPAASGHALPKIFRSLMSEPDSEIIDFYPEEFPIDMNGKKMSWQGIALLPFIDQDRLLTAV 750

  Fly   642 VPYYDQLTGEEVKRNKRGDNYLYISNQSPHYKKV-KKISEKDDESVCKAISF----DGMRGTLGK 701
            ...|..|:..|..||.||:..|.|||::.:|::. ||:..|::.:....:.|    .|:.|.:.|
Yeast   751 RAQYPLLSDAERARNIRGEPVLLISNKNANYERFSKKLYSKENNNNNVVVKFQHFKSGLSGIVSK 815

  Fly   702 TELNTAISGVLKSPISG--LSDINDNITVTTTFR---DPEYDEDYIFEAKRLENAVDPPQVLPNE 761
            ......::|.:..||.|  |.:::..:.:..::|   .|..::..|...           .:|:|
Yeast   816 DVEGFELNGKIVCPIQGGSLPNLSTTLILKMSYRLIPLPSRNKSIILNG-----------FIPSE 869

  Fly   762 QSGNKHRPVIGFNSHLTRAYVPDSGHRMLNAGIRNQQGGGGN---------GGGG--------GG 809
                   ||:       .||..||.....|....:::...||         |..|        ||
Yeast   870 -------PVL-------TAYDLDSIMYKYNNQNYSRRWNFGNDLKQNIVPVGPKGITQYKPRTGG 920

  Fly   810 YGQGGGYGQGIGGNQGQSYQNNSRNYNYNYNNNYNQHQGGGYQNNYNNRQQQQYGHNQRFNQDNS 874
            | :...|...:..|..|...|..|| :||....:|..:..|..|||  ||...|
Yeast   921 Y-RAFFYFAELSRNNVQPAHNYGRN-SYNSQPGFNNSRYDGGNNNY--RQNSNY----------- 970

  Fly   875 NQQQRNFNNYNGPRNNNYQQQGGSRQQNQNYRRF 908
                || |||:|.||:. |..|.|..:|....|:
Yeast   971 ----RN-NNYSGNRNSG-QYSGNSYSRNNKQSRY 998

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rat1	NP_609082.1	XRN1	1..735	CDD:227382	345/882 (39%)
RAT1	NP_014691.1	XRN1	1..1006	CDD:227382	392/1074 (36%)