DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rat1 and XRN3

DIOPT Version :9

Sequence 1:	NP_001260166.1	Gene:	Rat1 / 33964	FlyBaseID:	FBgn0031868	Length:	908	Species:	Drosophila melanogaster
Sequence 2:	NP_565114.1	Gene:	XRN3 / 843900	AraportID:	AT1G75660	Length:	1020	Species:	Arabidopsis thaliana

Alignment Length:	1036	Identity:	419/1036 - (40%)
Similarity:	562/1036 - (54%)	Gaps:	172/1036 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGVPAFFRWLSRKYPSVIIECNENKQVDADTGRNIYEDPTLPNPNGIEFDNLYLDMNGIIHPCTH 65
            ||||:|:|||:.|||.::.:..|.:.|:.: |..|..|.:.||||.:|:||||||||||||||.|
plant     1 MGVPSFYRWLAEKYPLLVADVIEEEPVEIE-GIKIPVDTSKPNPNNLEYDNLYLDMNGIIHPCFH 64

  Fly    66 PEDKPAPKNEDEMMVAIFECIDRLFGIVRPRKLLYMAIDGVAPRAKMNQQRSRRFRAAKETTEKR 130
            |||:|:|...:|:...:|:.|||||.:|||||||||||||||||||||||||||||:||:.::..
plant    65 PEDRPSPTTFEEVFQCMFDYIDRLFVMVRPRKLLYMAIDGVAPRAKMNQQRSRRFRSAKDASDAA 129

  Fly   131 LEIARIREELLSRGCKLPPEKEKGEHFDSNCITPGTPFMDRLSKCLHYFVHDRQNNNPAWKGIKV 195
            .|..|:|||....|.:||| |...:.||||.|||||.||..||..|.|:||.|.|::..||.|||
plant   130 AEEERLREEFEREGRRLPP-KVDSQVFDSNVITPGTEFMGVLSIALQYYVHLRLNHDVGWKNIKV 193

  Fly   196 ILSDANVPGEGEHKIMDYIRKQRAQPDHDPNTQHVLCGADADLIMLGLATHEPNFTIIRE-EFLP 259
            ||||||||||||||||.|||.||..|..||||:|.|.|.|||||||||||||.:|:|:|| .:.|
plant   194 ILSDANVPGEGEHKIMSYIRLQRNLPGFDPNTRHCLYGLDADLIMLGLATHEVHFSILREVVYTP 258

  Fly   260 NKPRPCDICNGFGHEMDKCVGLGATAPTSANFKPDVPIGAEVKFIFVRLSVLREYLKQTLEMPNL 324
            .:...|.:|...||....|.|........::.|.|.....:..:.|:.:.||||||:..:.:||.
plant   259 GQQERCFLCGQMGHFASNCEGKPKKRAGESDEKGDGNDFVKKPYQFLHIWVLREYLELEMRIPNP 323

  Fly   325 PFEYSFERALDDWVFMCFFVGNDFLPHLPSLEIREGAVDRLVELYKKCVYKTRGYLTDSGDVNLD 389
            |||...||.:||::|:|||||||||||:|:|||||||::.|:.:|||......|||||....||.
plant   324 PFEIDLERIVDDFIFICFFVGNDFLPHMPTLEIREGAINLLMAVYKKEFRSFDGYLTDGCKPNLK 388

  Fly   390 RVQLIMTDLGNAEDQIFKSR----QRREEQFKARDKARKRQERNQDHGSLNQ------SAFG--- 441
            ||:..:..:|:.||:||:.|    ||:.|:.| ||||.|..:|..|.....|      :.|.
plant   389 RVEQFIQAVGSFEDKIFQKRAMQHQRQAERVK-RDKAGKATKRMDDEAPTVQPDLVPVARFSGSR 452

  Fly   442 -ASAVGPNSQQRSVGNYKEEAAALRNRKRTS----------DMANLDDEDEEEN----------- 484
             |||..|:..|.:.|    .:|..:..:|.|          |:.|..:.||.||
plant   453 LASAPTPSPFQSNDG----RSAPHQKVRRLSPGSSVGAAIVDVENSLESDERENKEELKTKLKEL 513

  Fly   485 --------------NDEVRLWEDGFKDRYYESKFDVAPGN--QQFRYAVALQYVRGLCWVLKYYY 533
                          .|:|:|.:.|:::||||.||.|....  ::.|..|.|:|..|||||:.||.
plant   514 IREKSDAFNSDTTEEDKVKLGQPGWRERYYEEKFSVVTPEEMERVRKDVVLKYTEGLCWVMHYYM 578

  Fly   534 QGCASWNWYFPYHYAPFASDFVNIQGLSTMFEKGTKPFNPLEQLMGVFPAASSSHVPEPWAKLMS 598
            :|..||.|::||||||||||..::..:...||.|| ||.|..||:||||||||..:||.:..||:
plant   579 EGVCSWQWFYPYHYAPFASDLKDLGEMDIKFELGT-PFKPFNQLLGVFPAASSHALPERYRTLMT 642

  Fly   599 DPESPIIDFYPEDFKIDLNGKKFAWQGVALLPFVDEKRLFKALVPYYDQLTGEEVKRNKRGDNYL 663
            ||.||||||||.||::|:|||:|:|||:|.|||:||:||.:|:......||.||.:||.|..:.|
plant   643 DPNSPIIDFYPTDFEVDMNGKRFSWQGIAKLPFIDERRLLEAVSEVEFTLTDEEKRRNSRMCDML 707

  Fly   664 YISNQ----------SPHYKKVKKISEKDDESVCKAISFDGMRGTLGKTELNTAISG-----VLK 713
            :|:..          ..|.:::......|.:...|....|||.|.|      |..||     |.:
plant   708 FIATSHRLAELVFSLDNHCRQLSARERVDFKVKIKPKLSDGMNGYL------TPCSGETHPPVFR 766

  Fly   714 SPISGLSDINDNITVTTTFRDPEYDE-------DYIFEAKRLE-NAVDPPQVLPNEQSGNKHRPV 770
            ||:.|:.||..|..:...:|.|:..|       ..||..|.:: ..:.||..|.:|.:|  .||:
plant   767 SPMEGMEDILTNQVICCIYRLPDAHEHITRPPPGVIFPKKTVDIGDLKPPPALWHEDNG--RRPM 829

  Fly   771 IGFNSH--------------------LTRAYVPDSGHRMLNAGIR-------------------- 795
              .|:|                    ::..::.::.||:::..::
plant   830 --HNNHGMHNNHGMHNNQGRQNPPGSVSGRHLGNAAHRLVSNSLQMGTDRYQTPTDVPAPGYGYN 892

  Fly   796 ---------NQQGGGGNGGGGGGYGQGGGYGQGIGGNQ---------GQSYQNNSRNYNYNYNNN 842
                     .|.||.....|..||.|...| |..||.|         .:.||:.||.
plant   893 PPQYVPPIPYQHGGYMAPPGAQGYAQPAPY-QNRGGYQPRGPSGRFPSEPYQSQSRE-------- 948

  Fly   843 YNQH--QGGGYQNNYNNRQQQQYGHNQRFNQDNSNQQQRNFNNYNGPRNNNYQQQGGSRQQ 901
             .||  :||||..|:.|:.|||..|.|      ...:|.|...|||   .::.||||...:
plant   949 -GQHASRGGGYSGNHQNQHQQQQWHGQ------GGSEQNNPRGYNG---QHHHQQGGDHDR 999

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rat1	NP_001260166.1	XRN1	1..735	CDD:227382	365/800 (46%)
Rat1	NP_001260166.1	XRN_N	1..255	CDD:281193	157/253 (62%)
XRN3	NP_565114.1	XRN1	1..823	CDD:227382	373/835 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	317	1.000	Domainoid score	I289
eggNOG	1	0.900	-	-		E1_COG5049
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6927
Inparanoid	1	1.050	673	1.000	Inparanoid score	I149
OMA	1	1.010	-	-		QHG54717
OrthoDB	1	1.010	-	-		D685597at2759
OrthoFinder	1	1.000	-	-		FOG0003161
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100417
Panther	1	1.100	-	-	O	PTHR12341
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2128
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840