Protein Alignment Rat1 and xrn2

DIOPT Version :10

• Sequence 1: NP_609082.1
• Gene: Rat1 / 33964
• FlyBaseID: FBgn0031868
• Length: 908
• Species: Drosophila melanogaster
• Sequence 2: XP_002939479.1
• Gene: xrn2 / 733834
• XenbaseID: XB-GENE-993157
• Length: 931
• Species: Xenopus tropicalis
• Alignment Length: 964
• Identity: 502/964 - (52%)
• Similarity: 624/964 - (64%)
• Gaps: 102/964 - (10%)

  Fly     1 MGVPAFFRWLSRKYPSVII--------ECNENKQVDADTGRNIYEDPTLPNPNGIEFDNLYLDMN 57
            ||||||||||||||||:|:        ||| |.::..||        |.||||.:||||||||||
 Frog     1 MGVPAFFRWLSRKYPSIIVHSVEEKPKECN-NIKIPVDT--------TKPNPNEVEFDNLYLDMN 56

  Fly    58 GIIHPCTHPEDKPAPKNEDEMMVAIFECIDRLFGIVRPRKLLYMAIDGVAPRAKMNQQRSRRFRA 122
            |||||||||||||||||||||||||||.|||||.|||||:|||||||||||||||||||||||||
 Frog    57 GIIHPCTHPEDKPAPKNEDEMMVAIFEYIDRLFNIVRPRRLLYMAIDGVAPRAKMNQQRSRRFRA 121

  Fly   123 AKETTEKRLEIARIREELLSRGCKLPPEKEKGEHFDSNCITPGTPFMDRLSKCLHYFVHDRQNNN 187
            :||..|...|..|||||:||:|..||||:.| |.||||||||||.|||.|:|||.|::.||.||:
 Frog   122 SKEGVESSEEKQRIREEVLSKGGYLPPEEVK-ERFDSNCITPGTEFMDNLAKCLRYYIADRLNND 185

  Fly   188 PAWKGIKVILSDANVPGEGEHKIMDYIRKQRAQPDHDPNTQHVLCGADADLIMLGLATHEPNFTI 252
            |.||.:.||||||:||||||||||||||:|||||.|||||.|.||||||||||||||||||.|||
 Frog   186 PGWKNLTVILSDASVPGEGEHKIMDYIRRQRAQPHHDPNTHHCLCGADADLIMLGLATHEPYFTI 250

  Fly   253 IREEFLPNKPRPCDICNGFGHEMDKCVGLGATAPTSANFKPDVPIGAEVKFIFVRLSVLREYLKQ 317
            |||||.||||:||.:|..||||:.:|.|:........:...|.|.|.|.:|||:||:||||||::
 Frog   251 IREEFKPNKPKPCGLCGQFGHEIKECQGMPREKKGEHDEFADTPPGCEQEFIFIRLNVLREYLEK 315

  Fly   318 TLEMPNLPFEYSFERALDDWVFMCFFVGNDFLPHLPSLEIREGAVDRLVELYKKCVYKTRGYLTD 382
            .|.|.:|||::.|||::|||||||||||||||||||||||||||:||||.:||..|:||.|||||
 Frog   316 ELTMASLPFQFDFERSVDDWVFMCFFVGNDFLPHLPSLEIREGAIDRLVNIYKNVVHKTGGYLTD 380

  Fly   383 SGDVNLDRVQLIMTDLGNAEDQIFKSRQRREEQFKARDKARKRQER--NQDHGSLNQSAFGASAV 445
            ||.|||:|||:||..:|..||.|||.|:..:|.||.|.|.||::.:  :|....:....|...|:
 Frog   381 SGFVNLERVQMIMLAVGEVEDNIFKKRKEDDEHFKRRQKERKKRMKAEHQKPSFVTSGQFAPRAL 445

  Fly   446 GPN--SQQRSVGNYKEEAAALR--------------NRKRTSDMANLDDEDEEENNDEVRLWEDG 494
            |..  |...::.|.::||..:|              .:||.::  ..|.|.|.|:|  :||||:|
 Frog   446 GQGSCSVPEAINNPRQEAYRMRMQNAHSVDNASPNTGQKRKAE--GSDSEPEPEDN--IRLWEEG 506

  Fly   495 FKDRYYESKFDVAPGNQQFRYAVALQYVRGLCWVLKYYYQGCASWNWYFPYHYAPFASDFVNIQG 559
            :|.|||::||||...:::||..|...||.||||||:|||||||||.|:||:|||||||||.||..
 Frog   507 WKQRYYKNKFDVDASDEKFRRKVVQSYVEGLCWVLRYYYQGCASWKWFFPFHYAPFASDFENISC 571

  Fly   560 LSTMFEKGTKPFNPLEQLMGVFPAASSSHVPEPWAKLMSDPESPIIDFYPEDFKIDLNGKKFAWQ 624
            |...||||||||.|||||||||||||.:.:||.|.:||:||:|.||||||:||.|||||||||||
 Frog   572 LFKEFEKGTKPFKPLEQLMGVFPAASGNFLPESWRRLMNDPDSSIIDFYPDDFAIDLNGKKFAWQ 636

  Fly   625 GVALLPFVDEKRLFKALVPYYDQLTGEEVKRNKRGDNYLYISNQSPHYKKVKKISEKDDESVCKA 689
            ||||||||||:||..||...|..||.:|.:||..|.:.:::....|....:.::...:.....:
 Frog   637 GVALLPFVDERRLRAALEEVYPDLTPDETRRNSLGGDSIFVGESHPLNDFIHELYRANTTEATQ- 700

  Fly   690 ISFDGMRGTLGKTELN---TAISGVLKSPISGLSDINDNITVTTTFRDPEYDEDYIFEAKRLENA 751
            |..:...|..||.:|.   ...:.:::||:..|.|::.|..::..|.||||::.|||:|..|:.|
 Frog   701 IPPELCHGIQGKVQLEEDPILPNKIIESPVPLLRDLSQNFAISIKFEDPEYEDGYIFKAVVLQGA 765

  Fly   752 VDP-PQVLPNE-QSGNKH---RPVIGFNSHLTRAYVPDSGHRMLNAGIRNQQGGGGNGGGGGGYG 811
            ..| |.:.|.: :..|:.   ||.:|||.:....::..|..|.|...:...:|           .
 Frog   766 KKPAPTLKPGDWEKSNQDRSWRPQLGFNQNRKPVHLDSSAFRTLGHTLPQTRG-----------P 819

  Fly   812 QGGGYGQGIGGNQGQSYQNNSRNYNYNYNNNY--------------NQHQGGGYQNN---YNNRQ 859
            :|||:           |.|.....:||..|.|              |....|.:.|.   ||...
 Frog   820 RGGGH-----------YSNAPPPGSYNPVNTYRMPNRSAALPSLMQNNRPQGSWSNRPPLYNQPP 873

  Fly   860 QQQYGHNQRFNQDNSNQQ--QRNFNNYNGPRNNNYQQQGG--SRQ---QNQNYR 906
            |:.:|..|..:....|||  ||..:||       ||:.||  :||   |.:||:
 Frog   874 QRNFGPMQNPHPAFMNQQMGQRGPSNY-------YQRYGGDLNRQGYNQGRNYQ 920

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rat1	NP_609082.1	XRN1	1..735	CDD:227382	446/762 (59%)
xrn2	XP_002939479.1	XRN1	1..917	CDD:227382	500/959 (52%)