Protein Alignment Rat1 and XRN1

DIOPT Version :10

• Sequence 1: NP_609082.1
• Gene: Rat1 / 33964
• FlyBaseID: FBgn0031868
• Length: 908
• Species: Drosophila melanogaster
• Sequence 2: XP_011511221.1
• Gene: XRN1 / 54464
• HGNCID: 30654
• Length: 1707
• Species: Homo sapiens
• Alignment Length: 735
• Identity: 275/735 - (37%)
• Similarity: 390/735 - (53%)
• Gaps: 120/735 - (16%)

  Fly     1 MGVPAFFRWLSRKYPSVIIECNENKQVDADTGRNIYEDPTLPNPNGIEFDNLYLDMNGIIHPCTH 65
            ||||.|:||:|.:||.:               ..:.::..:|     ||||||||||||||.|:|
Human     1 MGVPKFYRWISERYPCL---------------SEVVKEHQIP-----EFDNLYLDMNGIIHQCSH 45

  Fly    66 PEDKPA--PKNEDEMMVAIFECIDRLFGIVRPRKLLYMAIDGVAPRAKMNQQRSRRFRAAKETTE 128
            |.|...  ..::|::...||..::.||.|::|||:.:||:|||||||||||||.||||:|||..:
Human    46 PNDDDVHFRISDDKIFTDIFHYLEVLFRIIKPRKVFFMAVDGVAPRAKMNQQRGRRFRSAKEAED 110

  Fly   129 KRLEIARIREELLSRGCKLPPEKEKGEHFDSNCITPGTPFMDRLSKCLHYFVHDRQNNNPAWKGI 193
            |       .::.:.:|..||.|    ..||||||||||.||.||.:.|.|||:.:.:.:.:|:|:
Human   111 K-------IKKAIEKGETLPTE----ARFDSNCITPGTEFMARLHEHLKYFVNMKISTDKSWQGV 164

  Fly   194 KVILSDANVPGEGEHKIMDYIRKQRAQPDHDPNTQHVLCGADADLIMLGLATHEPNFTIIREEFL 258
            .:..|....|||||||||::||.::|:|||||||:|.|.|.|||||||||.:||.:|:::|||..
Human   165 TIYFSGHETPGEGEHKIMEFIRSEKAKPDHDPNTRHCLYGLDADLIMLGLTSHEAHFSLLREEVR 229

  Fly   259 PNKPRPCDICNGFGHEMDKCVGLGATAPTSANFKPDVPIGAEVKFIFVRLSVLREYLKQTLEM-- 321
            ....:...:|                ||            .|..|..:.||::|||:.....:
Human   230 FGGKKTQRVC----------------AP------------EETTFHLLHLSLMREYIDYEFSVLK 266

  Fly   322 PNLPFEYSFERALDDWVFMCFFVGNDFLPHLPSLEIREGAVDRLVELYKKCVYKTRGYLTDSGDV 386
            ..:.|:|..||.:|||:.|.|.|||||:||||.|.|...|:..|...|...:.:..||:.:||.:
Human   267 EKITFKYDIERIIDDWILMGFLVGNDFIPHLPHLHINHDALPLLYGTYVTILPELGGYINESGHL 331

  Fly   387 NLDRVQLIMTDLGNAEDQIFK--------------SRQRREEQFKARDKARKRQERNQDHGSLNQ 437
            ||.|.:..:..|.:.:.:.|.              ::...|....|.::||..:|:.:..|..|.
Human   332 NLPRFEKYLVKLSDFDREHFSEVFVDLKWFESKVGNKYLNEAAGVAAEEARNYKEKKKLKGQENS 396

  Fly   438 SAFGASAVGPNSQQRSVGNYKEEAAALRNRKRTSDMANLDDEDEEENNDEVRLWEDGFKDRYYES 502
            ..:.|..             |.|...:.::.      ||:||.|:::..|....:  :|..||.:
Human   397 LCWTALD-------------KNEGEMITSKD------NLEDETEDDDLFETEFRQ--YKRTYYMT 440

  Fly   503 KFDVAPGNQQFRYAVALQYVRGLCWVLKYYYQGCASWNWYFPYHYAPFASDFVNIQGLSTMFEKG 567
            |..|...:..|....|..||:.:.|:|.|||.|..||:||:|||||||.||..||..|...||.|
Human   441 KMGVDVVSDDFLADQAACYVQAIQWILHYYYHGVQSWSWYYPYHYAPFLSDIHNISTLKIHFELG 505

  Fly   568 TKPFNPLEQLMGVFPAASSSHVPEPWAKLMSDPESPIIDFYPEDFKIDLNGKKFAWQGVALLPFV 632
             |||.|.|||:.|.||||.:.:|..:..||::.:||||::||.|||.|||||:..|:.|.|:||:
Human   506 -KPFKPFEQLLAVLPAASKNLLPACYQHLMTNEDSPIIEYYPPDFKTDLNGKQQEWEAVVLIPFI 569

  Fly   633 DEKRLFKALVPYYDQLTGEEVKRNK----------RGDNYLYISNQSPHYKKVKKISEKDDESVC 687
            |||||.:|:......|..||.|||:          |...::|   .||..:|...|     |..|
Human   570 DEKRLLEAMETCNHSLKKEERKRNQHSECLMCWYDRDTEFIY---PSPWPEKFPAI-----ERCC 626

  Fly   688 ---KAISFDGMRGTLGKTEL 704
               |.||.|..|..:.|.::
Human   627 TRYKIISLDAWRVDINKNKI 646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rat1	NP_609082.1	XRN1	1..735	CDD:227382	275/735 (37%)
XRN1	XP_011511221.1	XRN1	1..735	CDD:227382	275/735 (37%)
		XRN1_D1	658..843	CDD:436418
		XRN1_D2_D3	853..934	CDD:436419
		SH3_12	1101..1171	CDD:465661