DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rat1 and xrn1

DIOPT Version :9

Sequence 1:	NP_001260166.1	Gene:	Rat1 / 33964	FlyBaseID:	FBgn0031868	Length:	908	Species:	Drosophila melanogaster
Sequence 2:	NP_957327.2	Gene:	xrn1 / 394008	ZFINID:	ZDB-GENE-040426-1203	Length:	1697	Species:	Danio rerio

Alignment Length:	695	Identity:	274/695 - (39%)
Similarity:	376/695 - (54%)	Gaps:	107/695 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGVPAFFRWLSRKYPSVIIECNENKQVDADTGRNIYEDPTLPNPNGIEFDNLYLDMNGIIHPCTH 65
            ||||.|:||:|.:||.:               ..:.::..:|     ||||||||||||||.|:|
Zfish     1 MGVPKFYRWISERYPCL---------------SEVVKEHQIP-----EFDNLYLDMNGIIHQCSH 45

  Fly    66 PEDKPA--PKNEDEMMVAIFECIDRLFGIVRPRKLLYMAIDGVAPRAKMNQQRSRRFRAAKETTE 128
            |.|:..  ..:|:::...||..::.||.|::|||:.:||:|||||||||||||.||||:|||..|
Zfish    46 PNDEDVHFRISEEKIFADIFHYLEVLFRIIKPRKVFFMAVDGVAPRAKMNQQRGRRFRSAKEAEE 110

  Fly   129 KRLEIARIREELLSRGCKLPPEKEKGEHFDSNCITPGTPFMDRLSKCLHYFVHDRQNNNPAWKGI 193
            |       .::.|.:|..||.|    ..||||||||||.||.||.:.|.||||::.:.:..|:|:
Zfish   111 K-------IKKALEKGEVLPTE----ARFDSNCITPGTDFMARLQEQLKYFVHNKLSTDKTWQGV 164

  Fly   194 KVILSDANVPGEGEHKIMDYIRKQRAQPDHDPNTQHVLCGADADLIMLGLATHEPNFTIIREEFL 258
            .|.||....|||||||||::||.:..:|.|:|||:|.|.|.|||||||||.:|||:|:::|||
Zfish   165 NVYLSGHETPGEGEHKIMEFIRSESTKPGHNPNTRHCLYGLDADLIMLGLTSHEPHFSLLREE-- 227

  Fly   259 PNKPRPCDICNGFGHEMDKCVGLGATAPTSANFKPDVPIGAEVKFIFVRLSVLREYLKQTLE--M 321
                    :..| |.:..|.:    |||            .|..|..:.||::|||:.....  .
Zfish   228 --------VRFG-GKKSQKRI----TAP------------EETTFHLLHLSLMREYIDYEFSELR 267

  Fly   322 PNLPFEYSFERALDDWVFMCFFVGNDFLPHLPSLEIREGAVDRLVELYKKCVYKTRGYLTDSGDV 386
            ..:.|||..||.:||||.|.|.|||||:||||.|.|...|:..|...|...:....|||.::|.:
Zfish   268 KKISFEYDLERIIDDWVLMGFLVGNDFIPHLPHLHINHDALPLLYRTYINVLPSLGGYLNENGHL 332

  Fly   387 NLDRVQLIMTDLGNAEDQIFKSRQRREEQFKARDKARKRQERNQDHGSLNQSAFGASAVGPNSQQ 451
            ||...:..:..|.:.:      |:...|.|                  ::...| .|.||.....
Zfish   333 NLTHFEKYLEKLSDFD------REHFSEVF------------------VDLKWF-ESKVGNKYVN 372

  Fly   452 RSVGNYKEEAAA--LRNRKRTSD---MANLDD-----------EDEEENNDEVRLWEDGF---KD 497
            .:.|...|||..  |:..|.:.|   :|.||.           |..||:.::..::|..|   |.
Zfish   373 EAAGLAAEEADGRDLKKSKSSDDSLCLAALDGVRDSHSTAGRAEGAEEDGEDDDMFETEFRQYKR 437

  Fly   498 RYYESKFDVAPGNQQFRYAVALQYVRGLCWVLKYYYQGCASWNWYFPYHYAPFASDFVNIQGLST 562
            .||.:|..|...:.:|....|..||.|:.|:|.|||.|..||:||:|||||||.||..||.|||.
Zfish   438 TYYMTKMGVEVVSDEFLANQAKCYVEGIQWILHYYYHGVQSWSWYYPYHYAPFLSDVRNISGLSL 502

  Fly   563 MFEKGTKPFNPLEQLMGVFPAASSSHVPEPWAKLMSDPESPIIDFYPEDFKIDLNGKKFAWQGVA 627
            .|:. .|||.|.|||:.|.|:||...:|:.:..||:...|||:::||:|||.|||||:..|:.|.
Zfish   503 TFDL-AKPFMPFEQLLAVLPSASKDLLPQCYQHLMTSLSSPIVEYYPQDFKTDLNGKQQEWEAVV 566

  Fly   628 LLPFVDEKRLFKALVPYYDQLTGEEVKRNKRGDNYLYISNQSPHY 672
            |:||:|||.|..|:.||...||..|..||:..:..:|..::...|
Zfish   567 LIPFIDEKCLLAAMEPYTHNLTPSEKARNRHTECAVYCYDKDLDY 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rat1	NP_001260166.1	XRN1	1..735	CDD:227382	274/695 (39%)
Rat1	NP_001260166.1	XRN_N	1..255	CDD:281193	123/255 (48%)
xrn1	NP_957327.2	XRN1	1..734	CDD:227382	274/695 (39%)
xrn1	NP_957327.2	XRN_N	1..226	CDD:281193	123/255 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5049
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D150649at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100417
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.720