Protein Alignment Rat1 and Xrn2

DIOPT Version :10

• Sequence 1: NP_609082.1
• Gene: Rat1 / 33964
• FlyBaseID: FBgn0031868
• Length: 908
• Species: Drosophila melanogaster
• Sequence 2: NP_001102066.2
• Gene: Xrn2 / 362229
• RGDID: 1310218
• Length: 951
• Species: Rattus norvegicus
• Alignment Length: 968
• Identity: 502/968 - (51%)
• Similarity: 611/968 - (63%)
• Gaps: 125/968 - (12%)

  Fly     1 MGVPAFFRWLSRKYPSVIIECNENKQVDADTGRNIYEDPTLPNPNGIEFDNLYLDMNGIIHPCTH 65
            ||||||||||||||||:|:.|.|.|..:.: |..|..|.:.||||.:||||||||||||||||||
  Rat     1 MGVPAFFRWLSRKYPSIIVNCVEEKPKECN-GVKIPVDASKPNPNDVEFDNLYLDMNGIIHPCTH 64

  Fly    66 PEDKPAPKNEDEMMVAIFECIDRLFGIVRPRKLLYMAIDGVAPRAKMNQQRSRRFRAAKETTEKR 130
            |||||||||||||||||||.|||||.|||||:|||||||||||||||||||||||||:||..|..
  Rat    65 PEDKPAPKNEDEMMVAIFEYIDRLFNIVRPRRLLYMAIDGVAPRAKMNQQRSRRFRASKEGMEAA 129

  Fly   131 LEIARIREELLSRGCKLPPEKEKGEHFDSNCITPGTPFMDRLSKCLHYFVHDRQNNNPAWKGIKV 195
            :|..|:|||:|::|..||||:.| |.||||||||||.|||.|:|||.|::.||.||:|.||.:.|
  Rat   130 VEKQRVREEILAKGGFLPPEEIK-ERFDSNCITPGTEFMDNLAKCLRYYIADRLNNDPGWKNLTV 193

  Fly   196 ILSDANVPGEGEHKIMDYIRKQRAQPDHDPNTQHVLCGADADLIMLGLATHEPNFTIIREEFLPN 260
            |||||:.|||||||||||||:|||||:|||||.|.|||||||||||||||||||||||||||.||
  Rat   194 ILSDASAPGEGEHKIMDYIRRQRAQPNHDPNTHHCLCGADADLIMLGLATHEPNFTIIREEFKPN 258

  Fly   261 KPRPCDICNGFGHEMDKCVGLGATAPTSANFKPD-----VPIGAEVKFIFVRLSVLREYLKQTLE 320
            ||:||.:||.||||:..|.||    |.....|.|     :|. ||.:|||:||:||||||::.|.
  Rat   259 KPKPCALCNQFGHEVKDCEGL----PREKKGKHDELADSLPC-AEGEFIFLRLNVLREYLERELT 318

  Fly   321 MPNLPFEYSFERALDDWVFMCFFVGNDFLPHLPSLEIREGAVDRLVELYKKCVYKTRGYLTDSGD 385
            |.:|||.:..||::|||||||||||||||||||||||||||:||||.:||..|:||.||||:||.
  Rat   319 MASLPFPFDVERSIDDWVFMCFFVGNDFLPHLPSLEIREGAIDRLVNIYKNVVHKTGGYLTESGY 383

  Fly   386 VNLDRVQLIMTDLGNAEDQIFKSRQRREEQFKARDK-ARKRQERNQDH------------GSLN- 436
            |||.|||:||..:|..||.|||.|:..|:.|:.|.| .|||.:|:|..            ||.|
  Rat   384 VNLQRVQMIMLAVGEVEDSIFKKRKDDEDSFRRRQKEKRKRMKRDQPAFTPSGILTPYALGSRNS 448

  Fly   437 ----------QSAF-------GASAVGPNSQQRSVGNYKEEAAALRNRKRTSDMANLDDEDEEEN 484
                      |:|:       .:.::.||:...|.|:    .:.|...||.::    |.:.|.|.
  Rat   449 PGCQVASNPRQAAYEMRMQSNSSPSISPNTSFASDGS----PSPLGGLKRKAE----DSDSEPEP 505

  Fly   485 NDEVRLWEDGFKDRYYESKFDVAPGNQQFRYAVALQYVRGLCWVLKYYYQGCASWNWYFPYHYAP 549
            .|.|||||.|:|.|||::||||...:::||..|...||.||||||:|||||||||.||:|:||||
  Rat   506 EDNVRLWEAGWKQRYYKNKFDVDAADEKFRRKVVQSYVEGLCWVLRYYYQGCASWKWYYPFHYAP 570

  Fly   550 FASDFVNIQGLSTMFEKGTKPFNPLEQLMGVFPAASSSHVPEPWAKLMSDPESPIIDFYPEDFKI 614
            |||||..|..:.:.||||||||.|||||||||||||.:.:|..|.||||||:|.|||||||||.|
  Rat   571 FASDFEGIADMPSEFEKGTKPFKPLEQLMGVFPAASGNFLPPTWRKLMSDPDSSIIDFYPEDFAI 635

  Fly   615 DLNGKKFAWQGVALLPFVDEKRLFKALVPYYDQLTGEEVKRNKRGDNYLYISNQSPHYKKVKKI- 678
            ||||||:|||||||||||||:||..||...|..||.||.:||..|.:.|::....|.:..:.::
  Rat   636 DLNGKKYAWQGVALLPFVDERRLRAALEEVYPDLTPEENRRNSLGSDVLFVGKVHPLHDFILELY 700

  Fly   679 ----SEKDD--ESVCKAISFDGMRGTLGKTELNTAISGVLKSPISGLSDINDNITVTTTFRDPEY 737
                :|..|  ..:|     .|::|.....|........:.||:..|.|:..|..::..|:||::
  Rat   701 QTGSTEPVDVPPELC-----HGIQGKFSLDEEAILPDQTVCSPVPMLRDLTQNTAISINFKDPQF 760

  Fly   738 DEDYIFEAKRLENAVDPPQVL-PNE----QSGNKHRPVIGFNS-----HLTRAYVPDSGHRMLNA 792
            .|||:|:|..|..|..|..|| |.:    .:|.:.:|.:|||.     ||.:|.....||.:
  Rat   761 AEDYVFKAIMLPGARKPAAVLKPGDWEKSSNGRQWKPQLGFNRDRRPVHLDQAAFRTLGHVI--- 822

  Fly   793 GIRNQQGGGGNGGGGGGYGQGGGYGQGIGGNQGQSYQNNSRNYNYNYNNNYNQHQGGGYQNNYNN 857
                     ..|.|.|.|                   :|:.....||       ||..|:.....
  Rat   823 ---------PRGSGTGVY-------------------SNTAPPPANY-------QGNVYRPLLRG 852

  Fly   858 RQQ-QQYGHNQRFNQDNSN------QQQRNFNNYNG-----PRNNNYQQQGGSRQQNQ 903
            :.| .:...|.| .|||..      |||| |:...|     |.|...|.|..:.|.||
  Rat   853 QAQIPKLMSNMR-PQDNWRGPPPLFQQQR-FDRSVGAEPLLPWNRMLQTQNAAFQPNQ 908

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rat1	NP_609082.1	XRN1	1..735	CDD:227382	450/776 (58%)
Xrn2	NP_001102066.2	XRN1	1..787	CDD:227382	463/805 (58%)