Protein Alignment Rat1 and xrn2

DIOPT Version :10

• Sequence 1: NP_609082.1
• Gene: Rat1 / 33964
• FlyBaseID: FBgn0031868
• Length: 908
• Species: Drosophila melanogaster
• Sequence 2: NP_001001944.2
• Gene: xrn2 / 321940
• ZFINID: ZDB-GENE-040426-2874
• Length: 952
• Species: Danio rerio
• Alignment Length: 959
• Identity: 507/959 - (52%)
• Similarity: 620/959 - (64%)
• Gaps: 89/959 - (9%)

  Fly     1 MGVPAFFRWLSRKYPSVIIECNENKQVDADTGRNIYEDPTLPNPNGIEFDNLYLDMNGIIHPCTH 65
            ||||||||||||||||:|:.|.|.|..:.: |..|..|.:.||||.:||||||||||||||||||
Zfish     1 MGVPAFFRWLSRKYPSIIVHCLEEKAKEYN-GVKIPVDTSKPNPNEVEFDNLYLDMNGIIHPCTH 64

  Fly    66 PEDKPAPKNEDEMMVAIFECIDRLFGIVRPRKLLYMAIDGVAPRAKMNQQRSRRFRAAKETTEKR 130
            |||||||||||||||||||.|||||.|||||::||||||||||||||||||||||||:||..|..
Zfish    65 PEDKPAPKNEDEMMVAIFEYIDRLFNIVRPRRVLYMAIDGVAPRAKMNQQRSRRFRASKEGVELA 129

  Fly   131 LEIARIREELLSRGCKLPPEKEKGEHFDSNCITPGTPFMDRLSKCLHYFVHDRQNNNPAWKGIKV 195
            .|..::|||::.||..||||:.| |.||||||||||.|||.|:|||.|:|.||..|:|.|:.|.|
Zfish   130 EEKQKMREEVIERGGYLPPEEIK-ERFDSNCITPGTEFMDNLAKCLRYYVADRLTNDPGWRNITV 193

  Fly   196 ILSDANVPGEGEHKIMDYIRKQRAQPDHDPNTQHVLCGADADLIMLGLATHEPNFTIIREEFLPN 260
            .||||:||||||||||||||:||.||:|||||.|.|||||||||||||||||||||||||||.||
Zfish   194 FLSDASVPGEGEHKIMDYIRRQRGQPNHDPNTHHCLCGADADLIMLGLATHEPNFTIIREEFKPN 258

  Fly   261 KPRPCDICNGFGHEMDKCVGLGATAPTSA-----NFKPDVPIGAEVKFIFVRLSVLREYLKQTLE 320
            |||||.:|:..|||:..|.||    |...     .|...:|: :|.:|||:||:||||||::.|.
Zfish   259 KPRPCALCSQMGHEIKDCQGL----PREKQGEHDEFADTIPV-SEQEFIFIRLAVLREYLERELT 318

  Fly   321 MPNLPFEYSFERALDDWVFMCFFVGNDFLPHLPSLEIREGAVDRLVELYKKCVYKTRGYLTDSGD 385
            |.:|||.:||||::|||||||||||||||||||||||||||:||||.:||..|:||.||||::|.
Zfish   319 MASLPFPFSFERSVDDWVFMCFFVGNDFLPHLPSLEIREGAIDRLVGIYKDVVHKTGGYLTENGF 383

  Fly   386 VNLDRVQLIMTDLGNAEDQIFKSRQRREEQFKARDK-ARKRQERNQDHGSLNQSAFGASAVGPNS 449
            |||:||:|||..:|.|||.|||.|:..:|.||.|.| .:||.:..|....|....|...|:|...
Zfish   384 VNLERVELIMQAVGVAEDNIFKKRKEDDESFKRRMKDKKKRMKAEQRPSFLPGGQFAPHALGGRD 448

  Fly   450 -------------QQRSVGNYKEEAAA------LRNRKRTSDMA----------NLDDEDEE-EN 484
                         :.|..||.:.:.||      :||.|.:::.:          ..||.|.| |.
Zfish   449 RPMAVQNARHAAFEMRMQGNQRNQDAAQSLRAMMRNGKGSAESSGSMDNRGVKRKADDSDSEPEP 513

  Fly   485 NDEVRLWEDGFKDRYYESKFDVAPGNQQFRYAVALQYVRGLCWVLKYYYQGCASWNWYFPYHYAP 549
            .|.|||||||:|.|||::||||...:.:||..|...||.||||||:|||||||||.||||:||||
Zfish   514 EDNVRLWEDGWKQRYYKTKFDVDATDDEFRKKVVQSYVEGLCWVLRYYYQGCASWKWYFPFHYAP 578

  Fly   550 FASDFVNIQGLSTMFEKGTKPFNPLEQLMGVFPAASSSHVPEPWAKLMSDPESPIIDFYPEDFKI 614
            |||||.:|:|:.:.||||||||.|||||||||||||.:.:|..|..|||||||.||||||:||.|
Zfish   579 FASDFKDIKGMFSDFEKGTKPFKPLEQLMGVFPAASGNFLPTTWRALMSDPESSIIDFYPDDFAI 643

  Fly   615 DLNGKKFAWQGVALLPFVDEKRLFKALVPYYDQLTGEEVKRNKRGDNYLYISNQSPHYKKVKKI- 678
            ||||||:|||||||||||||:||..||...|:.||.|||:||..|.:.:::.........::::
Zfish   644 DLNGKKYAWQGVALLPFVDERRLRAALAEVYNDLTPEEVRRNSLGSDVMFVGRSHALCDFIQELY 708

  Fly   679 -SEKDDESVCKAISFDGMRGTLGKTELNTAISGVLKSPISGLSDINDNITVTTTFRDPEYDEDYI 742
             :|....:...|....|::|.|...|.......:::|||..|.||:.|..:...|:||:|.:.::
Zfish   709 RAESHTATEIPAEFCHGIQGILNLDEDPILPDKLVESPIPVLRDISSNCAIGIKFKDPQYADGFV 773

  Fly   743 FEAKRLENAVDPPQVL-PN--EQSG-NKHRPVIGFNSHLTRAYVPDSGHRMLNAGIRNQQGGG-- 801
            |:|..|..|..|.:|| |.  |||. ...||.:|||.:..:|::..|..|.||..:....|.|
Zfish   774 FKAVILPGAKIPNKVLKPGDWEQSNRGPWRPQLGFNPNRQQAHLDQSAFRKLNHHVGRSDGPGIY 838

  Fly   802 GNGGGGGGYGQGGGYGQGIGGNQGQSYQNNSRNYNYNYNNNYNQHQGGGYQNNYNNRQQQQYGHN 866
            |:|.....:.:||.|              :|.....||      |||     ||...|:..|..:
Zfish   839 GSGPPSDAHRRGGAY--------------SSAPPPTNY------HQG-----NYRPPQRDHYSQS 878

  Fly   867 QRFNQDNSNQQQRNFNNYNGPR--------NNNYQQQGGSRQQNQNYRR 907
            |   ...|.|...|..:|  ||        :...|.||.|.||||...|
Zfish   879 Q---SQYSRQPHMNTGSY--PRFQQGSHGWDRAMQNQGSSYQQNQQRGR 922

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rat1	NP_609082.1	XRN1	1..735	CDD:227382	450/771 (58%)
xrn2	NP_001001944.2	XRN1	1..796	CDD:227382	461/801 (58%)