Protein Alignment Rat1 and Xrn1

DIOPT Version :10

• Sequence 1: NP_609082.1
• Gene: Rat1 / 33964
• FlyBaseID: FBgn0031868
• Length: 908
• Species: Drosophila melanogaster
• Sequence 2: XP_006243656.1
• Gene: Xrn1 / 300944
• RGDID: 1309713
• Length: 1728
• Species: Rattus norvegicus
• Alignment Length: 725
• Identity: 276/725 - (38%)
• Similarity: 393/725 - (54%)
• Gaps: 100/725 - (13%)

  Fly     1 MGVPAFFRWLSRKYPSVIIECNENKQVDADTGRNIYEDPTLPNPNGIEFDNLYLDMNGIIHPCTH 65
            ||||.|:||:|.:||.:               ..:.::..:|     ||||||||||||||.|:|
  Rat     1 MGVPKFYRWISERYPCL---------------SEVVKEHQIP-----EFDNLYLDMNGIIHQCSH 45

  Fly    66 PEDKPA--PKNEDEMMVAIFECIDRLFGIVRPRKLLYMAIDGVAPRAKMNQQRSRRFRAAKETTE 128
            |.|...  ..::|::...||..::.||.|::|||:.:||:|||||||||||||.||||:|||..:
  Rat    46 PNDDDVHFRISDDKIFTDIFHYLEVLFRIIKPRKVFFMAVDGVAPRAKMNQQRGRRFRSAKEAED 110

  Fly   129 KRLEIARIREELLSRGCKLPPEKEKGEHFDSNCITPGTPFMDRLSKCLHYFVHDRQNNNPAWKGI 193
            |       .::.:.:|..||.|    ..||||||||||.||.||.:.|.|||:.:.:.:.:|:|:
  Rat   111 K-------IKKAIEKGETLPTE----ARFDSNCITPGTEFMARLHEHLKYFVNMKISTDKSWQGV 164

  Fly   194 KVILSDANVPGEGEHKIMDYIRKQRAQPDHDPNTQHVLCGADADLIMLGLATHEPNFTIIREEFL 258
            .:..|....|||||||||::||.::|:|||||||:|.|.|.|||||||||.:||.:|:::|||..
  Rat   165 TIYFSGHETPGEGEHKIMEFIRSEKAKPDHDPNTRHCLYGLDADLIMLGLTSHEAHFSLLREEVR 229

  Fly   259 PNKPRPCDICNGFGHEMDKCVGLGATAPTSANFKPDVPIGAEVKFIFVRLSVLREYLKQTLE--M 321
            ....:...:|                ||            .|..|..:.||::|||:.....  .
  Rat   230 FGGKKTQRVC----------------AP------------EETTFHLLHLSLMREYIDYEFSALK 266

  Fly   322 PNLPFEYSFERALDDWVFMCFFVGNDFLPHLPSLEIREGAVDRLVELYKKCVYKTRGYLTDSGDV 386
            ..:.|:|..|:.:|||:.|.|.|||||:||||.|.|...|:..|...|...:.:..||:.:||.:
  Rat   267 EKITFKYDIEKIIDDWILMGFLVGNDFIPHLPHLHINHDALPLLYGTYIAILPELGGYINESGHL 331

  Fly   387 NLDRVQLIMTDLGNAEDQIFKSRQRREEQFKARDKARKRQERNQDHGSLNQSAFGASAVGPNS-- 449
            ||.|.:..:..|.:.:          .|.|.......|..|....:..||::| ||:|....|
  Rat   332 NLPRFERYLVKLSDFD----------REHFSEVFVDLKWFESKVGNKYLNEAA-GAAAEEAKSCK 385

  Fly   450 QQRSV-GNYKEEAAALRNRKRTSDMANLDD-EDEEENNDEVRLWEDGF---KDRYYESKFDVAPG 509
            .:|.| |.....:.|..:::....:|:.|: |||.|::|   |:|..|   |..||.:|..|...
  Rat   386 DKRKVKGQENSLSWAALDKREGEGVASRDNFEDETEDDD---LFETEFRQYKRTYYMTKMGVDVV 447

  Fly   510 NQQFRYAVALQYVRGLCWVLKYYYQGCASWNWYFPYHYAPFASDFVNIQGLSTMFEKGTKPFNPL 574
            :.:|....|..||:.:.|:|.|||.|..||:||:|||||||.||..||..|...||.| |||.|.
  Rat   448 SDEFLADQAACYVQAIQWILHYYYHGVQSWSWYYPYHYAPFLSDIRNISTLKIHFELG-KPFKPF 511

  Fly   575 EQLMGVFPAASSSHVPEPWAKLMSDPESPIIDFYPEDFKIDLNGKKFAWQGVALLPFVDEKRLFK 639
            |||:.|.|:||.:.:|..:..||:..:||||::||.|||.|||||:..|:.|.|:||:|||||.:
  Rat   512 EQLLAVLPSASKTLLPTCYQHLMTSEDSPIIEYYPPDFKTDLNGKQQEWEAVVLIPFIDEKRLLE 576

  Fly   640 ALVPYYDQLTGEEVKRNKRGD----------NYLYISNQSPHYKKVKKISEKDDESVCKAISFDG 694
            |:......|..||.|||:..:          .:.|.|.....:..:::.|.:     .|.||.|.
  Rat   577 AMETCNHSLKKEERKRNQHSECLMCWYDSDTEFTYSSPWPEKFPAIERCSTR-----YKIISLDA 636

  Fly   695 MRGTLGKTEL 704
            .|..:.|.::
  Rat   637 WRVDINKNKI 646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rat1	NP_609082.1	XRN1	1..735	CDD:227382	276/725 (38%)
Xrn1	XP_006243656.1	XRN1	1..735	CDD:227382	276/725 (38%)
		XRN1_D1	658..843	CDD:436418
		XRN1_D2_D3	853..934	CDD:436419
		SH3_12	1101..1171	CDD:465661
		DSRM_SF	1478..1543	CDD:444671