DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rat1 and XRN2

DIOPT Version :9

Sequence 1:	NP_001260166.1	Gene:	Rat1 / 33964	FlyBaseID:	FBgn0031868	Length:	908	Species:	Drosophila melanogaster
Sequence 2:	NP_001304889.1	Gene:	XRN2 / 22803	HGNCID:	12836	Length:	1028	Species:	Homo sapiens

Alignment Length:	978	Identity:	487/978 - (49%)
Similarity:	595/978 - (60%)	Gaps:	133/978 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 WLSRKYPSVII-------ECNENKQVDADTGRNIYEDPTLPNPNGIEFDNLYLDMNGIIHPCTHP 66
            |:|.:...:::       |||         |..|..|.:.||||.:|||||||||||||||||||
Human    88 WVSEEVQRLLLSNACQPKECN---------GVKIPVDASKPNPNDVEFDNLYLDMNGIIHPCTHP 143

  Fly    67 EDKPAPKNEDEMMVAIFECIDRLFGIVRPRKLLYMAIDGVAPRAKMNQQRSRRFRAAKETTEKRL 131
            ||||||||||||||||||.|||||.|||||:|||||||||||||||||||||||||:||..|..:
Human   144 EDKPAPKNEDEMMVAIFEYIDRLFSIVRPRRLLYMAIDGVAPRAKMNQQRSRRFRASKEGMEAAV 208

  Fly   132 EIARIREELLSRGCKLPPEKEKGEHFDSNCITPGTPFMDRLSKCLHYFVHDRQNNNPAWKGIKVI 196
            |..|:|||:|::|..||||:.| |.||||||||||.|||.|:|||.|::.||.||:|.||.:.||
Human   209 EKQRVREEILAKGGFLPPEEIK-ERFDSNCITPGTEFMDNLAKCLRYYIADRLNNDPGWKNLTVI 272

  Fly   197 LSDANVPGEGEHKIMDYIRKQRAQPDHDPNTQHVLCGADADLIMLGLATHEPNFTIIREEFLPNK 261
            ||||:.|||||||||||||:|||||:|||||.|.|||||||||||||||||||||||||||.|||
Human   273 LSDASAPGEGEHKIMDYIRRQRAQPNHDPNTHHCLCGADADLIMLGLATHEPNFTIIREEFKPNK 337

  Fly   262 PRPCDICNGFGHEMDKCVGLGATAPTSANFKPD-----VPIGAEVKFIFVRLSVLREYLKQTLEM 321
            |:||.:||.||||:..|.||    |.....|.|     :|. ||.:|||:||:||||||::.|.|
Human   338 PKPCGLCNQFGHEVKDCEGL----PREKKGKHDELADSLPC-AEGEFIFLRLNVLREYLERELTM 397

  Fly   322 PNLPFEYSFERALDDWVFMCFFVGNDFLPHLPSLEIREGAVDRLVELYKKCVYKTRGYLTDSGDV 386
            .:|||.:..||::|||||||||||||||||||||||||.|:||||.:||..|:||.||||:||.|
Human   398 ASLPFTFDVERSIDDWVFMCFFVGNDFLPHLPSLEIRENAIDRLVNIYKNVVHKTGGYLTESGYV 462

  Fly   387 NLDRVQLIMTDLGNAEDQIFKSRQRREEQFKARDK-ARKRQERNQ----DHGSLNQSAFGASAVG 446
            ||.|||:||..:|..||.|||.|:..|:.|:.|.| .|||.:|:|    ..|.|...|.| |...
Human   463 NLQRVQMIMLAVGEVEDSIFKKRKDDEDSFRRRQKEKRKRMKRDQPAFTPSGILTPHALG-SRNS 526

  Fly   447 PNSQQRSVGNYKEEAAALR-----------NRKRTSD-----MANL-----DDEDEEENNDEVRL 490
            |.||..|  |.::.|..:|           |...|||     :..:     |.:.|.|..|.|||
Human   527 PGSQVAS--NPRQAAYEMRMQNNSSPSISPNTSFTSDGSPSPLGGIKRKAEDSDSEPEPEDNVRL 589

  Fly   491 WEDGFKDRYYESKFDVAPGNQQFRYAVALQYVRGLCWVLKYYYQGCASWNWYFPYHYAPFASDFV 555
            ||.|:|.|||::||||...:::||..|...||.||||||:|||||||||.||:|:|||||||||.
Human   590 WEAGWKQRYYKNKFDVDAADEKFRRKVVQSYVEGLCWVLRYYYQGCASWKWYYPFHYAPFASDFE 654

  Fly   556 NIQGLSTMFEKGTKPFNPLEQLMGVFPAASSSHVPEPWAKLMSDPESPIIDFYPEDFKIDLNGKK 620
            .|..:.:.||||||||.|||||||||||||.:.:|..|.||||||:|.|||||||||.|||||||
Human   655 GIADMPSDFEKGTKPFKPLEQLMGVFPAASGNFLPPSWRKLMSDPDSSIIDFYPEDFAIDLNGKK 719

  Fly   621 FAWQGVALLPFVDEKRLFKALVPYYDQLTGEEVKRNKRGDNYLYISNQSPHYKKVKKISEKDD-- 683
            :|||||||||||||:||..||...|..||.||.:||..|.:.|::....|.:..:.::.:...
Human   720 YAWQGVALLPFVDERRLRAALEEVYPDLTPEETRRNSLGGDVLFVGKHHPLHDFILELYQTGSTE 784

  Fly   684 -----ESVCKAISFDGMRGTLGKTELNTAISGVLKSPISGLSDINDNITVTTTFRDPEYDEDYIF 743
                 ..:|     .|::|.....|.......::.||:..|.|:..|..|:..|:||::.|||||
Human   785 PVEVPPELC-----HGIQGKFSLDEEAILPDQIVCSPVPMLRDLTQNTVVSINFKDPQFAEDYIF 844

  Fly   744 EAKRLENAVDPPQVL-PNE----QSGNKHRPVIGFNS-----HLTRAYVPDSGHRMLNAGIRNQQ 798
            :|..|..|..|..|| |::    .:|.:.:|.:|||.     ||.:|.....||.|
Human   845 KAVMLPGARKPAAVLKPSDWEKSSNGRQWKPQLGFNRDRRPVHLDQAAFRTLGHVM--------- 900

  Fly   799 GGGGNGGGGGGYG---------QGGGYGQGIGGN-QGQSYQNNSRNYNYNYNNNYNQHQGGGYQN 853
               ..|.|.|.|.         ||..|...:.|. |.....:|.|.                 |:
Human   901 ---PRGSGTGIYSNAAPPPVTYQGNLYRPLLRGQAQIPKLMSNMRP-----------------QD 945

  Fly   854 NYNNR----QQQQYGH----------NQRFNQDNSNQQQRNFNNYNGPRNNNYQQQGGSRQQNQN 904
            ::...    |||::..          |:.....|:..|...:....||  ..|..:...|...|.
Human   946 SWRGPPPLFQQQRFDRGVGAEPLLPWNRMLQTQNAAFQPNQYQMLAGP--GGYPPRRDDRGGRQG 1008

  Fly   905 YRR 907
            |.|
Human  1009 YPR 1011

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rat1	NP_001260166.1	XRN1	1..735	CDD:227382	437/770 (57%)
Rat1	NP_001260166.1	XRN_N	1..255	CDD:281193	178/252 (71%)
XRN2	NP_001304889.1	XRN_N	113..331	CDD:281193	171/218 (78%)
XRN2	NP_001304889.1	XRN1	118..865	CDD:227382	443/760 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152385
Domainoid	1	1.000	426	1.000	Domainoid score	I604
eggNOG	1	0.900	-	-		E1_COG5049
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6927
Inparanoid	1	1.050	901	1.000	Inparanoid score	I380
Isobase	1	0.950	-	0	Normalized mean entropy	S1160
OMA	1	1.010	-	-		QHG54717
OrthoDB	1	1.010	-	-		D150649at33208
OrthoFinder	1	1.000	-	-		FOG0003161
OrthoInspector	1	1.000	-	-		oto90019
orthoMCL	1	0.900	-	-		OOG6_100417
Panther	1	1.100	-	-	LDO	PTHR12341
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1677
SonicParanoid	1	1.000	-	-		X2128
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750