DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rat1 and xrn-2

DIOPT Version :9

Sequence 1:	NP_001260166.1	Gene:	Rat1 / 33964	FlyBaseID:	FBgn0031868	Length:	908	Species:	Drosophila melanogaster
Sequence 2:	NP_496958.2	Gene:	xrn-2 / 175071	WormBaseID:	WBGene00006964	Length:	975	Species:	Caenorhabditis elegans

Alignment Length:	989	Identity:	483/989 - (48%)
Similarity:	609/989 - (61%)	Gaps:	97/989 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGVPAFFRWLSRKYPSVIIECNENKQVDADTGRNIYEDPTLPNPNGIEFDNLYLDMNGIIHPCTH 65
            ||||||||||::|||:.::..||::|.|.| |..:..|.|.||||..||||||||||||||||||
Worm     1 MGVPAFFRWLTKKYPATVVNANEDRQRDQD-GNRVPVDCTQPNPNFQEFDNLYLDMNGIIHPCTH 64

  Fly    66 PEDKPAPKNEDEMMVAIFECIDRLFGIVRPRKLLYMAIDGVAPRAKMNQQRSRRFRAAKETTEKR 130
            |||:|||||||||...|||.|||::.|||||:|||||||||||||||||||||||||:||..||.
Worm    65 PEDRPAPKNEDEMFALIFEYIDRIYSIVRPRRLLYMAIDGVAPRAKMNQQRSRRFRASKEMAEKE 129

  Fly   131 LEIARIREELLSRGCKLPPEKEKGEHFDSNCITPGTPFMDRLSKCLHYFVHDRQNNNPAWKGIKV 195
            ..|...|..|::.|..:||:|::..||||||||||||||.||:..|.|::|||..|:.:|..|::
Worm   130 ASIEEQRNRLMAEGIAVPPKKKEEAHFDSNCITPGTPFMARLADALRYYIHDRVTNDASWANIEI 194

  Fly   196 ILSDANVPGEGEHKIMDYIRKQRAQPDHDPNTQHVLCGADADLIMLGLATHEPNFTIIREEFLPN 260
            ||||||||||||||||||:||||..|.|||||.|.||||||||||||:||||.||.||||||:||
Worm   195 ILSDANVPGEGEHKIMDYVRKQRGNPAHDPNTVHCLCGADADLIMLGIATHEANFNIIREEFVPN 259

  Fly   261 KPRPCDICNGFGHEMDKCVGLGATAPTSANFKPDV--PIGAEVKFIFVRLSVLREYLKQTLEMPN 323
            :||.||:|..:|||:.:|.|    |....:...|.  |...|..|||:|:.||||||::.|.|||
Worm   260 QPRACDLCGQYGHELKECRG----AENETDLGDDYCKPEQREKNFIFLRIPVLREYLEKELSMPN 320

  Fly   324 LPFEYSFERALDDWVFMCFFVGNDFLPHLPSLEIREGAVDRLVELYKKCVYKTRGYLTDSGDVNL 388
            |||::..|||||||||:|||||||||||||||||||||:|||::|||:.||:.:||||..|...|
Worm   321 LPFKFDVERALDDWVFLCFFVGNDFLPHLPSLEIREGAIDRLIKLYKEMVYQMKGYLTKDGIPEL 385

  Fly   389 DRVQLIMTDLGNAEDQIFKSRQRREEQFKARDKARK----------RQERNQDHGSLNQSAF--- 440
            |||::||..||..||:|||.||:.||:|:...:.:|          |..|.:..|...|.||
Worm   386 DRVEMIMKGLGRVEDEIFKRRQQDEERFQENQRNKKARMQMYGGGGRGGRGRGRGRGQQPAFVPT 450

  Fly   441 --------------GASAVGPNSQQR-------------SVGNYK--------EEAAALRNRKRT 470
                          |.|.....|:.|             :..|.|        |..|.:.:|||.
Worm   451 HGILAPMAAPMHHSGESTRQMASEARQTAMKFTNDANETAAANLKALLNVKGEESPADIASRKRK 515

  Fly   471 SDMANLDDEDEEEN--NDEVRLWEDGFKDRYYESKFDVAPGNQQFRYAVALQYVRGLCWVLKYYY 533
            ::...:..|:||:.  .|::||:|.|:|||||.:||||...:.:||:.||..||.||||||:|||
Worm   516 AEQPLIKPEEEEDEGPKDDIRLYESGWKDRYYRAKFDVGSDDIEFRHRVAWAYVEGLCWVLRYYY 580

  Fly   534 QGCASWNWYFPYHYAPFASDFVNIQGLSTMFEKGTKPFNPLEQLMGVFPAASSSHVPEPWAKLMS 598
            ||||||:||||||||||||||..:......|.:.|||||||||||.||||||..|:|..|.|||.
Worm   581 QGCASWDWYFPYHYAPFASDFETVGEFQPDFTRPTKPFNPLEQLMSVFPAASKQHLPVEWQKLMI 645

  Fly   599 DPESPIIDFYPEDFKIDLNGKKFAWQGVALLPFVDEKRLFKALVPYYDQLTGEEVKRNKRGDNYL 663
            ..:|||||.||.||:|||||||:|||||||||||||.||...|...|..||.||.:||.||.|.:
Worm   646 QDDSPIIDLYPADFRIDLNGKKYAWQGVALLPFVDETRLLATLQSVYPTLTAEEKQRNTRGPNRI 710

  Fly   664 YISNQSPHYKKVKKISE-KDDESV-CKAISFDGMRGTLGKTELNTAISGVLKSPIS--GLSDIND 724
            :|......::..::::| |.|:.| ......:|:.|.:......||......||::  ...|:..
Worm   711 FIGRNHKSFEFFQQVAESKSDDLVPLDPTLLNGVSGKIAYDSTATAPGLPFVSPVNHDECQDLPT 775

  Fly   725 NITVTTTFRDPEYDEDYIFEAKRLENAVDPPQVLP----NEQSGNKHRPVIGFNSHLTRAYVPDS 785
            |..:...:.||||.:||||.|.||:.|.:|.:.|.    |::...:::|.:|||.:..|..:..|
Worm   776 NCGICVLYEDPEYPQDYIFPALRLDGAKEPEKTLKPDDWNDRRDGRYQPQVGFNRNAPRGSLDQS 840

  Fly   786 GHRMLNAGIRNQQGGG------------GNGGGGGGYGQGGGYGQGIGGNQGQSYQNNSRNYNYN 838
            |||.::..:|...|||            |.|||||||.....:|:..||..|    ...:.|:..
Worm   841 GHRQVHHYVRGGGGGGGGYRGNSYDDRRGGGGGGGGYNDRQDFGRNYGGRDG----GGPQRYHDQ 901

  Fly   839 YNNNYNQHQGGGYQNNYNNRQQQQYG-----HNQRFNQDNSNQQQRNFNNYNGPRNNNYQQQ--- 895
            .......:|||||...|........|     ::|.:|||     ||......|.....||:.
Worm   902 QQQRQGGYQGGGYGGGYGGGGGGGGGGGGGSYHQPYNQD-----QRRGGRGGGGGPPGYQRPPYR 961

  Fly   896 ---GGSRQQNQNYR 906
               ||....|.::|
Worm   962 GGGGGGYHGNSSWR 975

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rat1	NP_001260166.1	XRN1	1..735	CDD:227382	422/789 (53%)
Rat1	NP_001260166.1	XRN_N	1..255	CDD:281193	175/253 (69%)
xrn-2	NP_496958.2	XRN1	1..848	CDD:227382	446/851 (52%)
xrn-2	NP_496958.2	XRN_N	1..254	CDD:281193	175/253 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162476
Domainoid	1	1.000	381	1.000	Domainoid score	I445
eggNOG	1	0.900	-	-		E1_COG5049
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6927
Inparanoid	1	1.050	908	1.000	Inparanoid score	I185
Isobase	1	0.950	-	0	Normalized mean entropy	S1160
OMA	1	1.010	-	-		QHG54717
OrthoDB	1	1.010	-	-		D150649at33208
OrthoFinder	1	1.000	-	-		FOG0003161
OrthoInspector	1	1.000	-	-		oto18797
orthoMCL	1	0.900	-	-		OOG6_100417
Panther	1	1.100	-	-	LDO	PTHR12341
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1677
SonicParanoid	1	1.000	-	-		X2128
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	16	15.790