DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rat1 and xrn-1

DIOPT Version :9

Sequence 1:	NP_001260166.1	Gene:	Rat1 / 33964	FlyBaseID:	FBgn0031868	Length:	908	Species:	Drosophila melanogaster
Sequence 2:	NP_496945.3	Gene:	xrn-1 / 175059	WormBaseID:	WBGene00012730	Length:	1591	Species:	Caenorhabditis elegans

Alignment Length:	736	Identity:	280/736 - (38%)
Similarity:	380/736 - (51%)	Gaps:	131/736 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGVPAFFRWLSRKYPSVIIECNENKQVDADTGRNIYEDPTLPNPNGIEFDNLYLDMNGIIHPCTH 65
            ||||.|:||.|.:||.:....||::               :|     ||||||||||||||.|:|
Worm     1 MGVPKFYRWTSERYPCLSEVINESQ---------------IP-----EFDNLYLDMNGIIHNCSH 45

  Fly    66 PEDKPAP--KNEDEMMVAIFECIDRLFGIVRPRKLLYMAIDGVAPRAKMNQQRSRRFRAAKETTE 128
            |.|....  ..|||:.|.||..|:.|:.::||:|:.:||:|||||||||||||:|||.:|: |..
Worm    46 PNDDDVTFRITEDEIFVNIFAYIENLYNLIRPQKVFFMAVDGVAPRAKMNQQRARRFMSAR-TAH 109

  Fly   129 KRLEIARIREELLSRGCKLPPEKEKGEHFDSNCITPGTPFMDRLSKCLHYFVHDRQNNNPAWKGI 193
            .:|..|      |..|..:|.|    ..||||||||||.||.||.:.|..::..:...:..|:|.
Worm   110 TQLAKA------LENGEIMPSE----ARFDSNCITPGTYFMTRLHQKLDDWIKTKSATDSRWQGR 164

  Fly   194 KVILSDANVPGEGEHKIMDYIRKQRAQPDHDPNTQHVLCGADADLIMLGLATHEPNFTIIREEFL 258
            |:|||..||||||||||||:||.:||...:||||:|.:.|.||||||||:.:|||:|:::|||..
Worm   165 KIILSGHNVPGEGEHKIMDFIRTERAGSSYDPNTRHCMYGLDADLIMLGIVSHEPHFSLLREEVT 229

  Fly   259 PN-KPRPCDICNGFGHEMDKCVGLGATAPTSANFKPDVPIGAEVKFIFVRLSVLREYLKQTLE-- 320
            .| :||..|                    ..|..||........||..:.||:|||||.....
Worm   230 FNTRPRKND--------------------NKATKKPKRTDSDVKKFHLLHLSLLREYLAWEFADV 274

  Fly   321 MPNLPFEYSFERALDDWVFMCFFVGNDFLPHLPSLEIREGAVDRLVELYKKCVYKTRGYLTDSGD 385
            ..:|||||..||.:|||:.:...||||||||||::.|.:.|:..|...|||.:....||:.::|.
Worm   275 KDSLPFEYEMERIVDDWILLGLLVGNDFLPHLPNIHIHDDALPLLYSTYKKVLPTLDGYINEAGY 339

  Fly   386 VNLDRVQLIMTDLGNAEDQIFKSRQRREEQFKARDKARKRQERNQDHGSLNQSAFGASAVGPNSQ 450
            :||.|.:..:.:|...:...|..| ..:|||....:.|......|:.......||.:|.|
Worm   340 LNLSRFEAFLAELALNDKTSFMER-LEDEQFMESKRIRVVDPEQQELAEPELVAFESSDV----- 398

  Fly   451 QRSVGNYKEEAAALRNRKRTSDMANLDDEDE-------EENNDEV----------------RLWE 492
                   ::||.|..::.........||||:       ||:.|::                :|.|
Worm   399 -------EDEAGAEESKDEAGGAGAEDDEDDAAFVSDHEEDGDDLEPGSGSDELLLSNLDAQLLE 456

  Fly   493 DGFKDR------------------------------------YYESKFDVAPGNQQFRYAVALQY 521
            |.|.|.                                    ||..|......::|.....|..|
Worm   457 DEFNDELATLALSGMNDADFANDVEACWTKTINNQFKRHKKTYYSDKLRYKNISKQQLREQAEGY 521

  Fly   522 VRGLCWVLKYYYQGCASWNWYFPYHYAPFASDFVNIQGLSTMFEKGTKPFNPLEQLMGVFPAASS 586
            ||.:.|.|.|||.||.||:|::|:|||||.||.....|:...||. ::||:|.|||:.|.|.||:
Worm   522 VRAIQWNLHYYYHGCVSWSWFYPHHYAPFISDVRGFVGMRMEFEL-SEPFHPFEQLLAVLPEASA 585

  Fly   587 SHVPEPWAKLM-SDP-ESPIIDFYPEDFKIDLNGKKFAWQGVALLPFVDEKRLFKALVPYYDQLT 649
            ..:|.|..:|| ||| :|||.||||.:|:.|||||:..|:.|.|:||::||||.:|:.....:||
Worm   586 DCLPRPLRELMSSDPAKSPICDFYPANFETDLNGKRNEWEAVVLIPFIEEKRLLEAIEAKRSRLT 650

  Fly   650 GEEVKRNKRGDNYLYISNQSP 670
            .||..||..|.:...||:..|
Worm   651 SEENARNSHGSHIQCISSPEP 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rat1	NP_001260166.1	XRN1	1..735	CDD:227382	280/736 (38%)
Rat1	NP_001260166.1	XRN_N	1..255	CDD:281193	123/255 (48%)
xrn-1	NP_496945.3	XRN1	1..782	CDD:227382	280/736 (38%)
		XRN_N	1..226	CDD:281193	123/255 (48%)
		FYDLN_acid	<363..437	CDD:302856	20/86 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5049
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1160
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D150649at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100417
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.670