DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nlg2 and CES2

DIOPT Version :9

Sequence 1:	NP_001245916.1	Gene:	Nlg2 / 33962	FlyBaseID:	FBgn0031866	Length:	1248	Species:	Drosophila melanogaster
Sequence 2:	NP_001352334.1	Gene:	CES2 / 8824	HGNCID:	1864	Length:	559	Species:	Homo sapiens

Alignment Length:	692	Identity:	176/692 - (25%)
Similarity:	271/692 - (39%)	Gaps:	186/692 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 ACALLVLLLLTSLWPDCCECLHGGSNTVKTKY-GLLRGIVVR---SSPLVEAFLGIPYASPPVGS 218
            ||.|| |||:.....|       .::.::|.: |.:.|.:|.   ::..|:.|||||:|.||:|.
Human    14 ACGLL-LLLVRGQGQD-------SASPIRTTHTGQVLGSLVHVKGANAGVQTFLGIPFAKPPLGP 70

  Fly   219 LRFMPPITPSTWKTVRSADRFSPVCPQNIPIPPNGPEALLEVPRARLAQLRRLLPLLKNQSEDCL 283
            |||.||..|.:|..||.......:|.|:          |..|....|:|.....| ..:.|||||
Human    71 LRFAPPEPPESWSGVRDGTTHPAMCLQD----------LTAVESEFLSQFNMTFP-SDSMSEDCL 124

  Fly   284 YLNIYVPYETRRQRRNTDDTTGEPKTKLSTVVFIHGESYDWNSGNPYDGSELAAHGNVIVVTINF 348
            ||:||.|..:..            .:.|..:|:|||.:..:...:.||||.|||..||:||.|.:
Human   125 YLSIYTPAHSHE------------GSNLPVMVWIHGGALVFGMASLYDGSMLAALENVVVVIIQY 177

  Fly   349 RLGIFGFLKTGGKESAQGNFGLMDLVAGLHWLKENLPAFGGDPQSITLLGYGTGAVLANILVVSP 413
            |||:.||..||.|. |.||:|.:|.||.|.|:::|:..|||:|..:|:.|...|....:.|||||
Human   178 RLGVLGFFSTGDKH-ATGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSLVVSP 241

  Fly   414 VASDLIQRTVLVSGSALSPWAIQKNPLFVKRRVAEQTGCHGDMLYDD-LAPCLRTKSVAELLAVK 477
            ::..|....::.||.||.|..|..:...:...||..:.|  |.:..: |..|||.||..|:||:.
Human   242 ISQGLFHGAIMESGVALLPGLIASSADVISTVVANLSAC--DQVDSEALVGCLRGKSKEEILAIN 304

  Fly   478 ---------VD------HPRFLVGFAPFVDGTVISPGANPLGSTTLPLGSAIVSTSGIEYANFPK 527
                     ||      ||:.|:..|.|      .|..:.:|......|..|.....| |....:
Human   305 KPFKMIPGVVDGVFLPRHPQELLASADF------QPVPSIVGVNNNEFGWLIPKVMRI-YDTQKE 362

  Fly   528 RDLIFCLTSVESYLDLSAQDLEFGFNETRRDRILRTFVRNNFHYHLNEIFAVLKNEYTDWEKAIR 592
            .|......:::..|.|......||      |.:...::.:|                       .
Human   363 MDREASQAALQKMLTLLMLPPTFG------DLLREEYIGDN-----------------------G 398

  Fly   593 NPLSSRDATLQFLSDGHTASPLIKLGYMHSLRGGRAYFLHFKHKT--IEEEYPQRSGSVRGEDVP 655
            :|.:.:....:.::|.....|.:::.:....| ...||..|:|:.  ::...|....:..|:::|
Human   399 DPQTLQAQFQEMMADSMFVIPALQVAHFQCSR-APVYFYEFQHQPSWLKNIRPPHMKADHGDELP 462

  Fly   656 FWLGLPMSPLFPHNY---TTQERQIGRLMLRYLSNFAKTGNPNQSTAKSVLPNPNEVLETALHQQ 717
            |    .....|..||   |.:|.|:.|.|::|.:|||:.||||
Human   463 F----VFRSFFGGNYIKFTEEEEQLSRKMMKYWANFARNGNPN---------------------- 501

  Fly   718 KKRSTSLTHPNLSEALNLAVLYNQRRSNAMHEKRSYIRRRLRSNDAAFTQLGISSERDVGSYDGD 782
                                                                           |:
Human   502 ---------------------------------------------------------------GE 503

  Fly   783 ELPFWDAYDVVNQLYVELGNKANIQSHYRGHKLSMWLNLIPQ 824
            .||.|..:|...| |::|..:..:....:.|:|..|...:||
Human   504 GLPHWPLFDQEEQ-YLQLNLQPAVGRALKAHRLQFWKKALPQ 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_001245916.1	COesterase	182..712	CDD:278561	155/554 (28%)
CES2	NP_001352334.1	COesterase	30..538	CDD:306613	165/660 (25%)
CES2	NP_001352334.1	Prevents secretion from ER. /evidence=ECO:0000255	556..559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810